All Phenotypes Prkacb<tm1Gsm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkacb^tm1Gsm/Prkacb^tm1Gsm	involves: 129X1/SvJ * C57BL/6	MGI:3628814
cx2	Prkaca^tm1Gsm/Prkaca⁺ Prkacb^tm1Gsm/Prkacb^tm1Gsm	involves: 129X1/SvJ * C57BL/6	MGI:3628809
cx3	Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb⁺	involves: 129X1/SvJ * C57BL/6	MGI:3628811
cx4	Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb^tm1Gsm	involves: 129X1/SvJ * C57BL/6	MGI:3628813

Allelic Composition	Prkacb^tm1Gsm/Prkacb^tm1Gsm
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkacb^tm1Gsm mutation (0 available); any Prkacb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:31731 )

• mutants are unable to maintain a potentiated response upon high-frequency stimulation, resulting in a late phase of long-term potentiation that is only 30% of controls, however paired-pulse facilitation is unaffected

absent long-term depression ( J:31731 )

decreased synaptic depression ( J:31731 )

• low-frequency stimulation fails to produce lasting synaptic depression as it does in wild-type

Allelic Composition	Prkaca^tm1Gsm/Prkaca⁺ Prkacb^tm1Gsm/Prkacb^tm1Gsm
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaca^tm1Gsm mutation (1 available); any Prkaca mutation (22 available)
Prkacb^tm1Gsm mutation (0 available); any Prkacb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Neural tube defects leading to spina bifida in Prkaca^tm1Gsm/Prkaca⁺ Prkacb^tm1Gsm/Prkacb^tm1Gsm and Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb⁺ mice

mortality/aging

postnatal lethality ( J:76765 )

• if mutant pups are kept with their parents, they are rejected and left out of the litter and die, probably from starvation

nervous system

increased neural tube apoptosis ( J:76765 )

• increase in apoptotic cells in the dorsal and lateral regions of the neural tube

abnormal neural tube morphology ( J:76765 )

• 100% show spinal neural tube defects

• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium

• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density

abnormal embryonic neuroepithelium morphology ( J:76765 )

• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density

spina bifida ( J:76765 )

• at the thoracic and lumbar regions

abnormal neuron specification ( J:76765 )

• altered neuronal identity in the neural tube posterior to the forelimb buds leading to a ventralized neural tube (appearance of ventral neuronal progenitors in the dorsal neural tube and loss of dorsal cell types)

abnormal dorsal root ganglion morphology ( J:76765 )

• dorsal root ganglia form in E10.5 embryos but regress at E12.5

• significant increase in cell death in the dorsal root ganglia adjacent to the affected neural tube

disorganized dorsal root ganglion ( J:76765 )

• dorsal root ganglia are formed in E10.5 embryos but are disorganized

skeleton

abnormal vertebral column morphology ( J:76765 )

• spinal column defects are located in the thoracic and lumbar regions

abnormal spine curvature ( J:76765 )

• ventral curvature of the spine at the defective region

abnormal vertebral arch morphology ( J:76765 )

• vertebral arches fail to fuse at the dorsal midline between forelimbs and hindlimbs

embryo

abnormal neural tube morphology ( J:76765 )

• 100% show spinal neural tube defects

• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium

• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density

abnormal embryonic neuroepithelium morphology ( J:76765 )

• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density

spina bifida ( J:76765 )

• at the thoracic and lumbar regions

cellular

increased neural tube apoptosis ( J:76765 )

• increase in apoptotic cells in the dorsal and lateral regions of the neural tube

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Neural tube defects leading to spina bifida in Prkaca^tm1Gsm/Prkaca⁺ Prkacb^tm1Gsm/Prkacb^tm1Gsm and Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb⁺ mice

mortality/aging

embryonic lethality, complete penetrance ( J:76765 )

• die by E14

nervous system

abnormal neural tube morphology ( J:76765 )

• 75% show spinal neural tube defects

• 25% show spinal neural tube defects and exencephaly

• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium

• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density

• exhibit an increase in apoptotic cells in the dorsal and lateral regions of the neural tube

abnormal embryonic neuroepithelium morphology ( J:76765 )

• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density

spina bifida ( J:76765 )

• at the thoracic and lumbar regions

exencephaly ( J:76765 )

• 25% show spinal neural tube defects and exencephaly; exencephaly alone is not observed

abnormal neuron specification ( J:76765 )

abnormal dorsal root ganglion morphology ( J:76765 )

• dorsal root ganglia form in E10.5 embryos but regress at E12.5

• significant increase in cell death in the dorsal root ganglia adjacent to the affected neural tube

disorganized dorsal root ganglion ( J:76765 )

• dorsal root ganglia are formed in E10.5 embryos but are disorganized

skeleton

abnormal vertebral column morphology ( J:76765 )

• spinal column defects are located in the thoracic and lumbar regions

abnormal spine curvature ( J:76765 )

• ventral curvature of the spine at the defective region

abnormal vertebral arch morphology ( J:76765 )

• vertebral arches fail to fuse at the dorsal midline between forelimbs and hindlimbs

embryo

abnormal neural tube morphology ( J:76765 )

• 75% show spinal neural tube defects

• 25% show spinal neural tube defects and exencephaly

• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium

• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density

• exhibit an increase in apoptotic cells in the dorsal and lateral regions of the neural tube

abnormal embryonic neuroepithelium morphology ( J:76765 )

• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density

spina bifida ( J:76765 )

• at the thoracic and lumbar regions

Allelic Composition	Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb^tm1Gsm
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:76765 )

• all double mutants found at E8.5 to E10.5 are in various stages of resorption, indicating early embryonic lethality

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