Phenotypes associated with this allele
Allelic
Composition |
Atf4tm1Tow/Atf4tm1Tow
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Genetic
Background |
either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
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Smaller fat pads in Atf4tm1Tow/Atf4tm1Tow mice
homeostasis/metabolism
endocrine/exocrine glands
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• beta cell proliferation is increased compared to in wild-type mice
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• beta cell area and mass are increased compared to in wild-type mice
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adipose tissue
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• at 8 weeks, mice exhibit decreased fad pad size and weight compared to in wild-type mice
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cellular
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• beta cell proliferation is increased compared to in wild-type mice
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Allelic
Composition |
Atf4tm1Tow/Atf4tm1Tow
|
|
Genetic
Background |
either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
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Atf4tm1Tow/Atf4tm1Tow mice show pancreatic hypotrophy
cellular
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• delay in differentiation
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craniofacial
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• skull trabeculae were short and thin, putatively compromising the protection of the brain during delivery
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• decreased mineralization
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• decreased mineralization
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digestive/alimentary system
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• number of acini is greatly reduced
• pancreatic acini are dispersed and are not in close proximity to neighboring acini resulting in an expanded extracellular space
• the centroacinar duct is greatly expanded in adults
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• acinar cell size is greatly reduced
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• acinar cells appear smaller with less zymogen granule content
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• exocrine pancreas of P4 mutants is severely underdeveloped
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endocrine/exocrine glands
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• adult pancreas contains numerous adipoctyes
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• number of acini is greatly reduced
• pancreatic acini are dispersed and are not in close proximity to neighboring acini resulting in an expanded extracellular space
• the centroacinar duct is greatly expanded in adults
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• acinar cell size is greatly reduced
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• acinar cells appear smaller with less zymogen granule content
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• exocrine pancreas of P4 mutants is severely underdeveloped
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skeleton
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• delay in differentiation
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• skull trabeculae were short and thin, putatively compromising the protection of the brain during delivery
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• decreased mineralization
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• decreased mineralization
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• decreased mineralization
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• normal skeletogenesis prior to E13, however defects were observed between E14 and E16
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• observed in both frontal and parietal bones, clavicles, and long bones
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Allelic
Composition |
Atf4tm1Tow/Atf4tm1Tow
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
|
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mortality/aging
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• most mice died within an hour of birth, although some mice persisted
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• some mice that survived the perinatal period died within the first 3 weeks of life
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cellular
growth/size/body
hematopoietic system
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• due to a cell-autonomous proliferation defect
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• severe fetal anemia
• mice that survived the perinatal period had mild anemia
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• impaired fetal liver definitive hematopoiesis
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liver/biliary system
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• the fetal liver was pale
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reproductive system
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• inspite of having grossly normal ovaries
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• most males that survived the perinatal period were infertile
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• mice that surivived the perinatal period and that were not completely sterile jad a reduced period of fertility and impregnated females at a reduced rate
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vision/eye
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• severe microphthalmia with no recognizable lens, anterior chamber, iris, or vitreous body
• eye development was impaired after E14.5, when the lens normally undergoes rapid cellular proliferation
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integument
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• by 1 week of age, surviving mice had only a sparse coat
• the delay resolved itself by adulthood
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Allelic
Composition |
Atf4tm1Tow/Atf4+
Ptprvtm1Asmi/Ptprv+
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Genetic
Background |
either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
Ptprvtm1Asmi mutation
(0 available);
any
Ptprv mutation
(30 available)
|
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homeostasis/metabolism
endocrine/exocrine glands
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• beta cell proliferation is increased compared to in wild-type mice
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cellular
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• beta cell proliferation is increased compared to in wild-type mice
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Allelic
Composition |
Atf4tm1Tow/Atf4+
Satb2tm1Rug/Satb2+
|
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Genetic
Background |
either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
Satb2tm1Rug mutation
(0 available);
any
Satb2 mutation
(43 available)
|
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skeleton
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• bone volume/total volume is reduced from 15.5% in wild-type to 8.53% in mutants
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• trabecular numbers/mm are reduced from 4.54 in wild-type to 2.48 in mutants
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• display a marked reduction of bone formation at E15.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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Bone volume and trabeculae analysis in Hivep3tm1GlmHivep3tm1Glm and Atf4tm1Tow/Atf4tm1Tow Hivep3tm1Glm/Hivep3tm1Glm mice
skeleton
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• increased bone formation rate
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Analysis Tools