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Phenotype Image Detail
Image
Caption As early as P4, Atf4tm1Tow/Atf4tm1Tow mice show fewer and smaller acinar cells in the exocrine pancreas (A, P4 wild type; B, P4 mutant, 400x). The arrows point to tubular structures. By three months of age, the majority of the exocrine pancreas is replaced by adipocytes (C, mutant).
Copyright This image is from Iida K, BMC Cell Biol 2007;8():38, an open-access article, licensee BioMed Central Ltd. J:129974
Associated
Alleles
Symbol Name
Atf4tm1Tow activating transcription factor 4; targeted mutation 1, Timothy Townes
Associated
Genotypes
Allelic Composition Genetic Background
Atf4tm1Tow/Atf4tm1Tow either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory