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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp8tm1.1Yuan
targeted mutation 1.1, Junying Yuan
MGI:2176089
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Casp8tm1.1Yuan/Casp8tm1.1Yuan involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1 MGI:3706520
cn2
 		Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Mx1-cre)1Cgn/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1 MGI:3055107
cn3
 		Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Alb1-cre)7Gsc/0 		involves: 129S1/Sv * 129X1/SvJ * MF1 MGI:3055104
cn4
 		Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Tie1-cre)9Ref/0 		involves: 129S1/Sv * 129X1/SvJ * MF1 MGI:3055108
cn5
 		Casp8tm1Wll/Casp8tm1.1Yuan
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129S1/Sv * 129X1/SvJ * MF1 MGI:3055111


Genotype
MGI:3706520
hm1
Allelic
Composition		 Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Yuan mutation (0 available); any Casp8 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:49459 )
• homozygotes exhibit no differences from homozygous Casp8tm1Yuan mutants in the kinetics of prenatal death, however no data is presented in J:49459

cardiovascular system
abnormal blood circulation ( J:49459 )
• homozygotes show no differences in the gross phenotype from homozygous Casp8tm1Yuan, however no data is presented in J:49459

growth/size/body
decreased embryo size ( J:49459 )

embryo

hematopoietic system

muscle




Genotype
MGI:3055107
cn2
Allelic
Composition		 Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Yuan mutation (0 available); any Casp8 mutation (42 available)
Casp8tm1Wll mutation (0 available); any Casp8 mutation (42 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:92722 )
• unlike mice that do not carry Casp8tm1.1Yuan, compound heterozygous mutants survive injection with an anti-Fas Ab

hematopoietic system
abnormal myeloblast morphology/development ( J:92722 )
• 2 days after induction of cre expression the ability of progenitor cells to form myeloid or B lymphoid colonies in culture or in transplant studies is significantly decreased
• the ability of these progenitors to differentiate into macrophages is also decreased after induction of cre expression




Genotype
MGI:3055104
cn3
Allelic
Composition		 Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Alb1-cre)7Gsc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Yuan mutation (0 available); any Casp8 mutation (42 available)
Casp8tm1Wll mutation (0 available); any Casp8 mutation (42 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:92722 )
• unlike mice that do not carry Casp8tm1.1Yuan, compound heterozygous mutants survive after injection with an anti-Fas Ab

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:92722 )
• unlike mice that do not carry Casp8tm1.1Yuan, compound heterozygous mutants survive and do not display liver damage after injection with an anti-Fas Ab




Genotype
MGI:3055108
cn4
Allelic
Composition		 Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Tie1-cre)9Ref/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Yuan mutation (0 available); any Casp8 mutation (42 available)
Casp8tm1Wll mutation (0 available); any Casp8 mutation (42 available)
Tg(Tie1-cre)9Ref mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:92722 )
• compound heterozygotes die around E12, similar to Casp8tm1.1Yuan homozygotes

cellular
myocardium necrosis ( J:92722 )
• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen

cardiovascular system
abnormal vitelline vasculature morphology ( J:92722 )
• the density of the vasculature in the yolk sac is decreased
visceral vascular congestion ( J:92722 )
• severe congestion of the liver and large vessels of the chest and abdomen similar to Casp8tm1.1Yuan homozygotes is seen
myocardium necrosis ( J:92722 )
• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen
globular heart ( J:92722 )
• the heart has a globose shape
thin ventricular wall ( J:92722 )
• around E12 thin and occasionally ruptured ventricular walls are seen
• heart defects are not seen in mutants at E10-E11.5
pericardial edema ( J:92722 )
• around E12, the pericardial space is enlarged consistent with pericardial edema

muscle
myocardium necrosis ( J:92722 )
• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen

embryo
abnormal vitelline vasculature morphology ( J:92722 )
• the density of the vasculature in the yolk sac is decreased
wavy neural tube ( J:92722 )
• an undulated neural tube is seen
abnormal visceral yolk sac morphology ( J:92722 )
• the density of the vasculature and amount of blood in the yolk sac is decreased
• increased cell death is seen in the yolk sac at E10.5 even when no signs of vascular degeneration were detected

hematopoietic system
hematopoietic system phenotype ( J:92722 )
N
• hematopoietic progenitor numbers are not decreased unlike in Casp8tm1.1Yuan homozygotes

homeostasis/metabolism
pericardial edema ( J:92722 )
• around E12, the pericardial space is enlarged consistent with pericardial edema

nervous system
wavy neural tube ( J:92722 )
• an undulated neural tube is seen




Genotype
MGI:3055111
cn5
Allelic
Composition		 Casp8tm1Wll/Casp8tm1.1Yuan
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Yuan mutation (0 available); any Casp8 mutation (42 available)
Casp8tm1Wll mutation (0 available); any Casp8 mutation (42 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage differentiation ( J:92722 )
• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages
• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

immune system
abnormal macrophage differentiation ( J:92722 )
• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages
• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

cellular
abnormal macrophage differentiation ( J:92722 )
• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages
• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory