Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r2tm1Lca mutation
(1 available);
any
Pik3r2 mutation
(38 available)
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neoplasm
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• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice
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neoplasm
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• following administration of inhaled adenovirus cre
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respiratory system
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• following administration of inhaled adenovirus cre
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neoplasm
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• following administration of inhaled adenovirus cre
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respiratory system
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• following administration of inhaled adenovirus cre
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cardiovascular system
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• most cardiomyocytes are reduced in size
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• heart size normalized to body weight or tibia length is about 20% smaller than in wild-type mice; however the structure of the heart is normal with no obvious signs of fibrosis or tissue damage
• the increase in heart size in response to exercise is decreased compared to wild-type mice
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muscle
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• most cardiomyocytes are reduced in size
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