Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1Hmo mutation
(0 available);
any
Cr1l mutation
(30 available)
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mortality/aging
N |
• homozygotes from mothers that are treated with a blocking anti-C5 antibody throughout pregnancy survive to adulthood
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• normal frequency of homozygotes until around E9.5
• all are dead by E16.5
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embryo
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• C3 (complement) deposited on the surface
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• C3 (complement) deposited on the surface
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• reduced deciduas at E9.5
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immune system
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• extensive invasion of polymorphonuclear inflammatory granulocytes around the ectoplacental cone and the trophoectoderm
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reproductive system
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• reduced deciduas at E9.5
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nervous system
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• 20 week-old mutants (from mothers treated with an anti-C5 antibody throughout pregnancy) show a reduction in complement factor H and a decrease in tau phosphorylation in the hippocampus, both markers of Alzheimer's disease
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Allelic Composition |
Cr1ltm1Hmo/Cr1l+
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Genetic Background |
involves: 129X1/SvJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1Hmo mutation
(0 available);
any
Cr1l mutation
(30 available)
|
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homeostasis/metabolism
renal/urinary system
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• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules
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• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfptm1Song mutation
(0 available);
any
Cfp mutation
(3 available)
Cr1ltm1Hmo mutation
(0 available);
any
Cr1l mutation
(30 available)
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mortality/aging
N |
• mice are produced in Mendelian ratios unlike Cr1ltm1Hmo homozygotes that exhibit embryonic lethality
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hematopoietic system
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• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation
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homeostasis/metabolism
hematopoietic system
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• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation
(2 available);
any
C3 mutation
(102 available)
Cr1ltm1Hmo mutation
(0 available);
any
Cr1l mutation
(30 available)
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mortality/aging
N |
• survival of double homozygotes is normal
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immune system
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• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type
• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells
• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice
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reproductive system
N |
• when mating double homozygous females to Crrytm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crrytm1Hmo homozygous pups are found
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