Mouse Genome Informatics
hm1
    Cr1ltm1Hmo/Cr1ltm1Hmo
involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• homozygotes from mothers that are treated with a blocking anti-C5 antibody throughout pregnancy survive to adulthood (J:197576)
• normal frequency of homozygotes until around E9.5
• all are dead by E16.5

embryogenesis
• C3 (complement) deposited on the surface
• C3 (complement) deposited on the surface
• reduced deciduas at E9.5 (J:59432)

immune system
• extensive invasion of polymorphonuclear inflammatory granulocytes around the ectoplacental cone and the trophoectoderm

reproductive system
• reduced deciduas at E9.5 (J:59432)

nervous system
• 20 week-old mutants (from mothers treated with an anti-C5 antibody throughout pregnancy) show a reduction in complement factor H and a decrease in tau phosphorylation in the hippocampus, both markers of Alzheimer's disease


Mouse Genome Informatics
ht2
    Cr1ltm1Hmo/Cr1l+
involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• significantly elevated serum urea nitrogen following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion
• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules

renal/urinary system
• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules
• significantly greater injury following 20 minutes of bilateral renal ischemia and 24 hours of reperfusion particularly in the proximal tubules


Mouse Genome Informatics
cx3
    Cfptm1Song/Cfptm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo

involves: 129 * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• mice are produced in Mendelian ratios unlike Cr1ltm1Hmo homozygotes that exhibit embryonic lethality (J:165497)


Mouse Genome Informatics
cx4
    C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo

involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation

homeostasis/metabolism
• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation


Mouse Genome Informatics
cx5
    C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Vsig4tm1Gne/Vsig4tm1Gne

involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal (J:138410)

homeostasis/metabolism
• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal (J:138410)


Mouse Genome Informatics
cx6
    C3tm1Hrc/C3tm1Hrc
Cr1ltm1Hmo/Cr1ltm1Hmo

involves: 129/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• survival of double homozygotes is normal (J:59432)

immune system
• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type
• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells
• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice

reproductive system
N
• when mating double homozygous females to Crrytm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crrytm1Hmo homozygous pups are found (J:86999)