All Phenotypes Dnd1<Ter> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnd1^Ter
teratoma
MGI:2158668

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnd1^Ter/Dnd1^Ter	129S1/Sv-Kit^W Oca2^p Tyr^c-ch	MGI:3690450
hm2	Dnd1^Ter/Dnd1^Ter	involves: 129S1/Sv * C57BL/6	MGI:3690452
ht3	Dnd1^Ter/Dnd1⁺	129S1/Sv-Kit^W Oca2^p Tyr^c-ch	MGI:3690451
ht4	Dnd1^Ter/Dnd1⁺	involves: 129P3/J	MGI:5696098
ht5	Dnd1^Ter/Dnd1⁺	involves: 129S1/Sv * C57BL/6	MGI:3690453
ht6	Dnd1^tm1Na/Dnd1^Ter	involves: 129P3/J * 129S6/SvEvTac	MGI:5696097
cx7	Dnd1^Ter/Dnd1^Ter Sf1^Gt(XD130)Byg/Sf1⁺	involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv	MGI:4836911
cx8	Apc^Min/Apc⁺ Dnd1^Ter/Dnd1⁺	involves: 129P3/J * C57BL/6J	MGI:5696099
ot9	Dnd1^Ter/?	129S1/Sv-Kit^W Oca2^p Tyr^c-ch	MGI:3690449

Allelic Composition	Dnd1^Ter/Dnd1^Ter
Genetic Background	129S1/Sv-Kit^W Oca2^p Tyr^c-ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased oocyte number ( J:7954 )

• in females, some ovaries show germ cell depletion with only a few cells present; female germ cells survive and matured into normal oocytes

• abnormal ovaries have ~10% normal number of oocytes

decreased male germ cell number ( J:7954 )

• at E15, a few germ cells are present in seminiferous tubules of males, and decline thereafter; no germ cells are present in early postnatal male mice

abnormal ovary morphology ( J:7954 )

• some germ cell deficient ovaries weigh more than wild-type; only seen when ovaries have several corpora lutea

small ovary ( J:7954 )

decreased ovary weight ( J:7954 )

• adult females have small ovaries (2 mg) compared to wild-type (5.4 mg)

small testis ( J:7954 )

decreased testis weight ( J:7954 )

• wet weights of germ cell-deficient testes are 20-25% that of wild-type testes

increased testicular teratoma incidence ( J:7954 )

• 94% (167/178) of homozygous males have testicular teratomas; 75% of affected males have bilateral teratomas, 19% unilateral teratomas, and 6% are tumor-free whereas wild-type mice have only a 1.4% incidence of spontaneous teratomas; left testis is affected in twice as many males as right testis

male infertility ( J:7954 )

• males with abnormal testes are sterile with or without presence of testicular tumor; germ cell deficient males in breeding for ~3 months produced no pregnancies or litters

neoplasm

increased testicular teratoma incidence ( J:7954 )

endocrine/exocrine glands

abnormal ovary morphology ( J:7954 )

• some germ cell deficient ovaries weigh more than wild-type; only seen when ovaries have several corpora lutea

small ovary ( J:7954 )

decreased ovary weight ( J:7954 )

• adult females have small ovaries (2 mg) compared to wild-type (5.4 mg)

small testis ( J:7954 )

decreased testis weight ( J:7954 )

• wet weights of germ cell-deficient testes are 20-25% that of wild-type testes

increased testicular teratoma incidence ( J:7954 )

cellular

decreased oocyte number ( J:7954 )

• in females, some ovaries show germ cell depletion with only a few cells present; female germ cells survive and matured into normal oocytes

• abnormal ovaries have ~10% normal number of oocytes

decreased male germ cell number ( J:7954 )

• at E15, a few germ cells are present in seminiferous tubules of males, and decline thereafter; no germ cells are present in early postnatal male mice

Allelic Composition	Dnd1^Ter/Dnd1^Ter
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testicular teratoma incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic mutants

• 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas

reproductive system

increased testicular teratoma incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic mutants

• 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas

endocrine/exocrine glands

increased testicular teratoma incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic mutants

• 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas

Allelic Composition	Dnd1^Ter/Dnd1⁺
Genetic Background	129S1/Sv-Kit^W Oca2^p Tyr^c-ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testicular teratoma incidence ( J:7954 )

• 17% (20/117) of males show testicular teratomas, only 2/117 have bilateral teratomas

endocrine/exocrine glands

increased testicular teratoma incidence ( J:7954 )

• 17% (20/117) of males show testicular teratomas, only 2/117 have bilateral teratomas

reproductive system

increased testicular teratoma incidence ( J:7954 )

• 17% (20/117) of males show testicular teratomas, only 2/117 have bilateral teratomas

Allelic Composition	Dnd1^Ter/Dnd1⁺
Genetic Background	involves: 129P3/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testis tumor incidence ( J:221231 )

• testicular germ cell tumor rate about 39%

reproductive system

increased testis tumor incidence ( J:221231 )

• testicular germ cell tumor rate about 39%

endocrine/exocrine glands

increased testis tumor incidence ( J:221231 )

• testicular germ cell tumor rate about 39%

Allelic Composition	Dnd1^Ter/Dnd1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased germ cell number ( J:7954 )

• 23% (29/126) of mice from N1 heterozygotes bred to 129/Sv-Dnd1^Ter heterozygotes are germ cell deficient; 29% (28/101) of mice from N2 heterozygotes bred to 129/Sv-Dnd1^Ter heterozygotes are germ cell deficient

• N1 intercrossing results in 20/100 offspring have germ cell deficiency

small ovary ( J:7954 )

• seen in some mice of N3 backcross to B6

small testis ( J:7954 )

• seen in some mice of N3 backcross to B6

increased testis tumor incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

increased testicular teratoma incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

neoplasm

increased testis tumor incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

increased testicular teratoma incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

endocrine/exocrine glands

small ovary ( J:7954 )

• seen in some mice of N3 backcross to B6

small testis ( J:7954 )

• seen in some mice of N3 backcross to B6

increased testis tumor incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

increased testicular teratoma incidence ( J:7954 )

• Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

cellular

decreased germ cell number ( J:7954 )

• N1 intercrossing results in 20/100 offspring have germ cell deficiency

Allelic Composition	Dnd1^tm1Na/Dnd1^Ter
Genetic Background	involves: 129P3/J * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)
Dnd1^tm1Na mutation (0 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:221231 )

reproductive system

decreased male germ cell number ( J:221231 )

• modestly reduced

decreased testis weight ( J:221231 )

• modestly reduce weight

endocrine/exocrine glands

decreased testis weight ( J:221231 )

• modestly reduce weight

cellular

decreased male germ cell number ( J:221231 )

• modestly reduced

Allelic Composition	Dnd1^Ter/Dnd1^Ter Sf1^Gt(XD130)Byg/Sf1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)
Sf1^Gt(XD130)Byg mutation (0 available); any Sf1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testis tumor incidence ( J:164224 )

• bilateral testicular tumor numbers decrease compared to Dnd1^Ter single mutant

decreased tumor incidence ( J:164224 )

• only 40% of mice develop testis tumor compared to Dnd1^Ter single mutant

endocrine/exocrine glands

small testis ( J:164224 )

• increase in number of bilateral small testes compared to Dnd1^Ter single mutant

increased testis tumor incidence ( J:164224 )

• bilateral testicular tumor numbers decrease compared to Dnd1^Ter single mutant

reproductive system

small testis ( J:164224 )

• increase in number of bilateral small testes compared to Dnd1^Ter single mutant

increased testis tumor incidence ( J:164224 )

• bilateral testicular tumor numbers decrease compared to Dnd1^Ter single mutant

male infertility ( J:164224 )

• increase in number of sterile mice compared to Dnd1^Ter single mutant

Allelic Composition	Apc^Min/Apc⁺ Dnd1^Ter/Dnd1⁺
Genetic Background	involves: 129P3/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:221231 )

• 1.5X increase in intestinal tumor rate relative to Apc single heterozygotes

• significantly elevated polyp mass

digestive/alimentary system

increased intestinal adenoma incidence ( J:221231 )

• 1.5X increase in intestinal tumor rate relative to Apc single heterozygotes

• significantly elevated polyp mass

Allelic Composition	Dnd1^Ter/?
Genetic Background	129S1/Sv-Kit^W Oca2^p Tyr^c-ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1^Ter mutation (1 available); any Dnd1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testicular teratoma incidence ( J:29502 )

• ~30% of males develop testicular teratomas, and the earliest spontaneous tumors observed were in testes of E16 fetuses; most teratomas are bilateral

• teratomas contain many types of mature tissues, such as epithelia (skin, mammary gland, alimentary, salivary gland and respiratory epithelia), muscle tissue, cartilage, bone, and brown and white adipose tissue

• primordial germ cells are highly susceptible to teratocarcinogenesis between E12-13, but become resistant by E14, as show in grafting experiments (embryonic genital ridges grafted onto adult testes)

endocrine/exocrine glands

increased testicular teratoma incidence ( J:29502 )

• ~30% of males develop testicular teratomas, and the earliest spontaneous tumors observed were in testes of E16 fetuses; most teratomas are bilateral

reproductive system

increased testicular teratoma incidence ( J:29502 )

• ~30% of males develop testicular teratomas, and the earliest spontaneous tumors observed were in testes of E16 fetuses; most teratomas are bilateral

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