About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apptm1Cwe
targeted mutation 1, Charles Weissmann
MGI:2154522
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apptm1Cwe/Apptm1Cwe 129S-Apptm1Cwe MGI:2177025
hm2
Apptm1Cwe/Apptm1Cwe B6.129S2-Apptm1Cwe MGI:3590205
hm3
Apptm1Cwe/Apptm1Cwe involves: 129S2/SvPas MGI:3718912
hm4
Apptm1Cwe/Apptm1Cwe involves: 129S2/SvPas * C57BL/6 MGI:2177008


Genotype
MGI:2177025
hm1
Allelic
Composition
Apptm1Cwe/Apptm1Cwe
Genetic
Background
129S-Apptm1Cwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Cwe mutation (0 available); any App mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• brain weight is reduced 10% relative to controls
• Background Sensitivity: greatly increased frequency of absent corpus callosum over controls in 129-derived genetic backgrounds
• Background Sensitivity: greatly reduced ventral hippocampal commissure; 71% reduced compared to controls
• reduced size of anterior commissure, independent of genetic background




Genotype
MGI:3590205
hm2
Allelic
Composition
Apptm1Cwe/Apptm1Cwe
Genetic
Background
B6.129S2-Apptm1Cwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Cwe mutation (0 available); any App mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• brain weight is reduced 10% relative to controls
• Background Sensitivity: 4-11% smaller than controls; absence of corpus callosum is not statistically significant in mutant lines with greater than 50% C57BL/6 genetic background contrbution when compared to controls
• Background Sensitivity: slightly reduced ventral hippocampal commissure; 13% reduced compared to controls
• reduced size of anterior commissure, independent of genetic background




Genotype
MGI:3718912
hm3
Allelic
Composition
Apptm1Cwe/Apptm1Cwe
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Cwe mutation (0 available); any App mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• abnormal circadian distribution of activity
• take about twice as long to find the platform and swim greater distances in a water maze
• decreased exploratory behavior under aversive conditions
• increased wall-hugging in a water maze
• swim speed is decreased by 19% compared to controls
• grip strength deficit of 23% compared to controls
• significantly increased activity levels at the beginning of the dark period and decreased activity levels at the end of the dark period compared to controls

nervous system
• brain wet weight is reduced by about 11% at 10 - 12 months of age
• deficit in long term potentiation in mice at 9 to 12 months of age

growth/size/body
• reduced by about 15% and 19% compared to wild-type in females and males, respectively at 2.4 months of age




Genotype
MGI:2177008
hm4
Allelic
Composition
Apptm1Cwe/Apptm1Cwe
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Cwe mutation (0 available); any App mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• on average, mutant mice weigh 10% less than controls

nervous system
N
• Background Sensitivity: absence of corpus callosum is not statistically significant in mutant lines with greater than 50% C57BL/6 genetic background contribution when compared to controls
• brain weight is reduced 10% relative to controls
• corpus callosum absent in 7 of 9 homozygous mutant pups, but only 1 of 8 heterozygotes and 1 of 8 wild-type controls, suggesting that this mutation contributes to an underlying predisposition for this trait in 129 substrain mice
• Background Sensitivity: slightly reduced ventral hippocampal commissure; 16% reduced compared to controls
• reduced size of anterior commissure, independent of genetic background

behavior/neurological
• in a two-chamber box test, mutant mice did not learn to avoid a shock by running from one chamber to another after a warning light conditioning stimulus
• mice show decreased exploratory stops during and after habituation in a new environment
• total path length covered by the mutant mice is 70% of that of controls
• mutant mice show a reduced ability to use visual cues after habituation to find a platform in the Morris water maze test
• significant behavioral differences to controls are reflected in total swimming time, percentage of time in the target quadrant and orientation towards the sunken platform
• the learning defect is not due to visual defects
• mice exhibit increased thigmotaxis (stopping along walls) and fewer excursions into the open field after habituation to a new environment





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory