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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ctnnb1tm4Wbm
targeted mutation 4, Walter Birchmeier
MGI:2148594
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:4413472
cn2
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd MGI:5547809
cn3
Ctnnb1tm4Wbm/Ctnnb1+
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:5435570
cn4
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Prrx1-cre)98Mlgn/0
involves: 129P2/OlaHsd MGI:4442425
cn5
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:4461250
cn6
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * C57BL/6 MGI:2673246
cn7
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1.1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * C57BL/6 MGI:2673250
cn8
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Pou3f4-cre)32Cren/?
involves: 129P2/OlaHsd * C57BL/6 MGI:2673243
cn9
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)39Mlr/?
involves: 129P2/OlaHsd * FVB/N MGI:3811550
cn10
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)10Mlr/?
involves: 129P2/OlaHsd * FVB/N MGI:3811549
cn11
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * FVB/N MGI:3773346
cn12
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Pax3tm1(cre)Joe/Pax3+
Not Specified MGI:3576470


Genotype
MGI:4413472
cn1
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth

integument
• in newborns and when skin is grafted onto wild-type mice




Genotype
MGI:5547809
cn2
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• enhanced infiltration in the skin
• decrease in gamma-delta TCR+ T cells (dendritic epidermal T cells) in the skin

hematopoietic system
• enhanced infiltration in the skin
• decrease in gamma-delta TCR+ T cells (dendritic epidermal T cells) in the skin




Genotype
MGI:5435570
cn3
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1+
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lack of hair follicles in Ctnnb1tm4Wbm/Ctnnb1+ Tg(KRT14-cre)1Efu/0 mice

integument




Genotype
MGI:4442425
cn4
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Prrx1-cre)98Mlgn/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(Prrx1-cre)98Mlgn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at E14.5, ectopic muscle splitting and muscle mispatterning in both fore- and hindlimbs are observed, due to deletion of Tbx5 in muscle connective tissue cells




Genotype
MGI:4461250
cn5
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Gli1tm3(cre/ERT2)Alj mutation (1 available); any Gli1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice
• however, development of female genital tracts is normal
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

renal/urinary system
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice




Genotype
MGI:2673246
cn6
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• hairless patches at 8 days of age
• hair placodes absent where Catnb is not expressed
• initial phase hair growth occurs until 16 days
• reduced number of zigzag hairs
• hair lost around 4 weeks of age and no regrowth




Genotype
MGI:2673250
cn7
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1.1(cre)Wbm/Krt14+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Krt14tm1.1(cre)Wbm mutation (0 available); any Krt14 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• no hairless skin patches at 8 days of age
• initial phase hair growth occurs until 16 days of age
• reduced number of zigzag hairs
• hair loss around 4 weeks of age and no regrowth
• hair shafts become separated from dermal papillae




Genotype
MGI:2673243
cn8
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Pou3f4-cre)32Cren/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• proliferation of cells declined by E10
• 45% at E11 to 50% at E11.5
• E11 proliferation rate down 35%
• 4.8X increase in progenitor cell death and apoptosis
• higher proportion of differentiated neurons to proliferative cells
• number of neurons unchanged
• changes similar to those seen in the spinal cord
• tissue mass of the midbrain was reduced
• progenitor domains in the midbrain and other areas of the brain reduced
• increased apoptosis
• ventricular zone absent at E12
• reduced area occupied by progenitor cells
• ventral progenitor are absent by E11.5
• absent dorsally by E12
• Larger area occupied by differentiated neurons(as determined immunohistochemically and gene markers)




Genotype
MGI:3811550
cn9
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)39Mlr/?
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(Cryaa-cre)39Mlr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice are pre-disposed to developing nuclear cataracts as they age but otherwise have a normal eye phenotype




Genotype
MGI:3811549
cn10
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)10Mlr/?
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(Cryaa-cre)10Mlr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at E14.5, the lens capsule is thinner than in controls
• the anterior capsule is extremely thin, whereas the posterior capsule is abnormally thick and diffuse at 1 day of age
• the close adherence of the iris to the remaining abnormal epithelial cells is further evidence of an abnormal lens capsule at 1 day of age
• at 21 days of age, abnormal fiber cells are surrounded by a very thin basement membrane that is often ruptured resulting in fiber cell extrusion into the vitreous and posterior chamber of the aqueous near the iris
• the cell cycle of lens epithelial cells is disrupted by E13.5 with 3-fold less cells being in the S phase or M phase
• at E14.5, epithelium is thin with the presence of blood cells found under an abnormal multilayered epithelium
• at P1, the lens epithelium is thin and the epithelial cells abnormally shaped
• at P21, the residual lens has no distinguishable epithelium and a thin basement membrane
• at E14.5, fiber cells displayed altered apical?basal polarity as evidenced by altered distribution of the tight junction protein, ZO1, disruption of apical actin filaments, and accumulations of extracellular matrix containing collagen
• at P1, fiber cells are poorly elongated and tend to be aligned more perpendicularly to the capsule than parallel
• at P21, the abnormal fiber cells are often extruding into the vitreous
• small lens size is discernable at 1 day of age and size is greatly reduced by 21 days of age
• small eye phenotype is discernable at eye opening at 12 days of age with greatly reduced eye size evident by weaning

integument
• occurs in patches on the cheek by 21 days of age
• occurs by 21 days of age




Genotype
MGI:3773346
cn11
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Pdx1-cre)6Tuv/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Tg(Pdx1-cre)6Tuv mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue

mortality/aging
• shortened lifespan, with a median survival of 29 days, although some mice do survive more than 6 months

growth/size/body
• small body size at birth that persists into adulthood

endocrine/exocrine glands
• in 17% of mutants that survived beyond 3 months, the pancreas has a liver-like histology
• numerous tubular structures suggesting pancreas acinar to duct metaplasia, however islets are intact
• acinar hypoplasia is seen by E16.5 and by 2 months of age, there is a near complete absence of acinar cell structures
• pancreas weighs on average 30% less than wild-type
• increase in parenchymal fibrosis
• decrease in the proliferation rate of pancreatic exocrine progenitors
• variable degree of surrounding inflammatory infiltrate which becomes more severe by 1 month of age; inflammatory infiltrate is reminiscent of pancreatitis

immune system
• variable degree of surrounding inflammatory infiltrate which becomes more severe by 1 month of age; inflammatory infiltrate is reminiscent of pancreatitis

digestive/alimentary system
• numerous tubular structures suggesting pancreas acinar to duct metaplasia, however islets are intact
• acinar hypoplasia is seen by E16.5 and by 2 months of age, there is a near complete absence of acinar cell structures




Genotype
MGI:3576470
cn12
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Pax3tm1(cre)Joe/Pax3+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (21 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• neural tube defects are seen at mid gestation

embryo
• neural tube defects are seen at mid gestation





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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory