All Phenotypes Gdnf<tm1Rosl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gdnf^tm1Rosl
targeted mutation 1, Arnon Rosenthal
MGI:2136843

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdnf^tm1Rosl/Gdnf^tm1Rosl	involves: 129S2/SvPas	MGI:3588501
hm2	Gdnf^tm1Rosl/Gdnf^tm1Rosl	involves: 129S2/SvPas * CD-1	MGI:3757647
ht3	Gdnf^tm1Rosl/Gdnf⁺	involves: 129S2/SvPas	MGI:3588504
ht4	Gdnf^tm1Rosl/Gdnf⁺	involves: 129S2/SvPas * C57BL/6	MGI:2675149
cx5	Gdnf^tm1Rosl/Gdnf⁺ Slit2^tm1Matl/Slit2^tm1Matl	involves: 129S2/SvPas	MGI:3043170
cx6	Gdnf^tm1Rosl/Gdnf^tm1Rosl Nrtn^tm1Jmi/Nrtn^tm1Jmi	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3588573
cx7	Gdnf^tm1Rosl/Gdnf⁺ Nrtn^tm1Jmi/Nrtn^tm1Jmi	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3588574
cx8	Bax^tm1Sjk/Bax^tm1Sjk Gdnf^tm1Rosl/Gdnf⁺	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3588576
cx9	Bid^tm1Sjk/Bid^tm1Sjk Gdnf^tm1Rosl/Gdnf⁺	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3588577
cx10	Gdnf^tm1Rosl/Gdnf⁺ Itga8^tm1Lfr/Itga8^tm1Lfr	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3715481
cx11	Gdnf^tm1Rosl/Gdnf⁺ Itga8^tm1Lfr/Itga8⁺	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3715482

Allelic Composition	Gdnf^tm1Rosl/Gdnf^tm1Rosl
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:33808 )

• die 1-1.5 days after birth

renal/urinary system

abnormal metanephric mesenchyme morphology ( J:33808 )

• do not have a properly developed metanephric blastema at E11.5

absent kidney ( J:33808 )

• 16 of 20 have complete bilateral renal agenesis

absent ureter ( J:33808 )

• 16 of 20 have complete uretal agenesis

absent ureteric bud ( J:33808 )

• absent ureteric bud

nervous system

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

absent enteric neurons ( J:33808 )

• vagal neural crest-derived neurons are absent in small and large intestine and only a few are detected in the stomach

abnormal innervation pattern to muscle ( J:110955 )

• peroneal nerve is reduced in diameter while tibial nerve diameter is increased in diameter; mutant phenotype is more severe than that of Ret^tm1Kln; Tg(Pgk1-cre)1Lni or Ret^tm1Kln;Tg(Nes-cre)1Kln mice

abnormal motor neuron innervation pattern ( J:132854 )

• posterior Psoas major lacks innervation

decreased motor neuron number ( J:132854 )

• loss of more than 20% of motor neurons at the lumbar level

• elevated apoptosis of motor neurons between 13.5 and E15.5

abnormal cranial ganglia morphology ( J:33808 )

• 40% reduction in the number of neurons and smaller size of neurons in petrosal-nodose ganglia of P0 mice, however no differences in hindbrain noradrenergic or midbrain dopaminergic neurons

small dorsal root ganglion ( J:33808 )

• 23% reduction in the number of neurons and smaller size of neurons in dorsal root ganglia of P0 mice

• however, no differences in trigeminal sensory and vestibular ganglia are seen

digestive/alimentary system

abnormal intestine morphology ( J:33808 )

• thinner smooth muscle in the intestinal wall

hematopoietic system

abnormal spleen red pulp morphology ( J:33808 )

• exhibit mild multifocal necrosis in the red pulp at sites of active hematopoiesis

immune system

abnormal spleen red pulp morphology ( J:33808 )

• exhibit mild multifocal necrosis in the red pulp at sites of active hematopoiesis

reproductive system

abnormal ovary topology ( J:33808 )

• reversal in the orientation of the ovary in relation to the abdominal viscera

endocrine/exocrine glands

abnormal ovary topology ( J:33808 )

• reversal in the orientation of the ovary in relation to the abdominal viscera

muscle

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

Allelic Composition	Gdnf^tm1Rosl/Gdnf^tm1Rosl
Genetic Background	involves: 129S2/SvPas * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:78718 )

• nerves to the cutaneous maximus and latissimus dorsi are missing or with reduced numbers of fibers by E11.5 to E12.5

abnormal spinal nerve morphology ( J:78718 )

• caudal nerve branches from the brachial plexus to the cutaneous maximus and latissimus dorsi become atrophied and misrouted by E11

abnormal spinal cord lateral motor column morphology ( J:78718 )

• reduced numbers of motor neurons expressing Pea3 in the lateral motor colomn of segments C5 to C8 of the spinal cord at E12.5

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:33808 )

• 4 of 26 have renal hypoplasia

absent kidney ( J:122519 )

• 9% kidney agenesis incidence

single kidney ( J:33808 )

• 7 of 26 have unilateral renal agenesis

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system

abnormal enteric nervous system morphology ( J:82456 )

• reduction in enteric nervous system precursor proliferation

abnormal enteric ganglia morphology ( J:82456 )

• hypoganglionic enteric nervous system

abnormal enteric neuron morphology ( J:82456 )

• 43% fewer small bowel neurons and 48% fewer colonic myenteric neurons, however acetylcholinesterase-stained myenteric plexus fiber counts in both the colon and small bowel and cell sizes of enteric neurons are normal

abnormal neurotransmitter secretion ( J:82456 )

• 70-95% reduction in substance P and VIP release

muscle

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Hirschsprung's disease		DOID:10487	OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644	J:82456

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺ Slit2^tm1Matl/Slit2^tm1Matl
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)
Slit2^tm1Matl mutation (2 available); any Slit2 mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal ureter morphology ( J:90324 )

• at E14.5 in 6/30 kidneys 2 ureters or 1 ureter and a blind-ending ectopic protusion are found, in 24/30 only a single ureter is found demonstrating a partial rescue of the Slit2^tm1Matl homozygous phenotype

• in 5/15 kidneys with a single ureter, the single ureter did not undergo remodeling and remained connected to the nephric duct, in the other 10/15 ureter remodeling was also rescued with the ureter connected to the bladder

Allelic Composition	Gdnf^tm1Rosl/Gdnf^tm1Rosl Nrtn^tm1Jmi/Nrtn^tm1Jmi
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)
Nrtn^tm1Jmi mutation (1 available); any Nrtn mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric ganglia morphology ( J:82456 )

• severe intestinal aganglionosis, similar to that seen in single homozygous Gdnf^tm1Rosl mice

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺ Nrtn^tm1Jmi/Nrtn^tm1Jmi
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system

abnormal enteric neuron morphology ( J:82456 )

• decrease in the number and cell size of small bowel and colon myenteric and submucosal neurons

• density of acetylcholinesterase-stained neuronal fibers in the myenteric plexus is reduced to a similar extent as in homozygous Nrtn^tm1Jmi mice

abnormal neurotransmitter secretion ( J:82456 )

• 70-95% reduction in substance P and VIP release

muscle

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Gdnf^tm1Rosl/Gdnf⁺
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:82456 )

• 32-33% and 43-48% reduction in submucosal and myenteric neurons, respectively, similar to that seen in single heterozygous Gdnf mutants

Allelic Composition	Bid^tm1Sjk/Bid^tm1Sjk Gdnf^tm1Rosl/Gdnf⁺
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bid^tm1Sjk mutation (1 available); any Bid mutation (44 available)
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:82456 )

• 32-33% and 43-48% reduction in submucosal and myenteric neurons, respectively, similar to that seen in single heterozygous Gdnf mutants

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺ Itga8^tm1Lfr/Itga8^tm1Lfr
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (18 available)
Itga8^tm1Lfr mutation (2 available); any Itga8 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:122519 )

• only kidney observed is highly dysplastic

small kidney ( J:122519 )

absent kidney ( J:122519 )

• 95% kidney agenesis incidence; only 1 kidney is found in total in 11 animals

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺ Itga8^tm1Lfr/Itga8⁺
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:122519 )

• 53% kidney agenesis incidence

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23