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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Msx1tm1Bero
targeted mutation 1, Benoit Robert
MGI:1933766
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Msx1tm1Bero/Msx1tm1Bero B6.129P2-Msx1tm1Bero MGI:3702323
hm2
Msx1tm1Bero/Msx1tm1Bero involves: 129P2/OlaHsd MGI:3607401
hm3
Msx1tm1Bero/Msx1tm1Bero involves: 129P2/OlaHsd * C57BL/6J MGI:2676083
ht4
Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5473567
cn5
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI MGI:5297709
cn6
Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Yvla/Msx2tm1Yvla
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI MGI:5297713
cx7
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129/Sv * 129P2/OlaHsd MGI:5613192
cx8
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * C57BL/6J MGI:2676082
cx9
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
involves: 129/Sv * BALB/c * C57BL/6 * SJL MGI:3797245
cx10
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129/Sv * C57BL/6 * NMRI MGI:3582224
cx11
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Yvla/Msx2tm1Yvla
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:3797244
cx12
Dlx5tm1Levi/Dlx5tm1Levi
Msx1tm1Bero/Msx1tm1Bero
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3702326
cx13
Barx1tm1Shiv/Barx1tm1Shiv
Msx1tm1Bero/Msx1+
involves: 129P2/OlaHsd * various MGI:5307914


Genotype
MGI:3702323
hm1
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Genetic
Background
B6.129P2-Msx1tm1Bero
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• newborn homozygotes die within a few hours after birth (J:42035)
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes die more rapidly than homozygotes on mixed genetic background (J:42035)
• newborn homozygotes die within a few hours after birth (J:42035)
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes die more rapidly than homozygotes on mixed genetic background (J:42035)

craniofacial
• at birth, homozygotes exhibit a rounded skull (J:42035)
• at birth, homozygotes exhibit a rounded skull (J:42035)
• newborn homozygotes lack alveolar processes (J:42035)
• newborn homozygotes lack alveolar processes (J:42035)
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin (J:42035)
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin (J:42035)
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities (J:42035)
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities (J:42035)
• molars develop until E13.5 and reach the bud stage but fail to develop further (J:42035)
• molars develop until E13.5 and reach the bud stage but fail to develop further (J:42035)
• at ~E13, the shape of the secondary palate is slightly altered (J:42035)
• at ~E13, the shape of the secondary palate is slightly altered (J:42035)
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• newborn homozygotes lack incisors (J:42035)
• newborn homozygotes lack incisors (J:42035)
• at P0, homozygotes lack mandibular molars (J:104286)
• at P0, homozygotes lack mandibular molars (J:104286)
• at birth, homozygotes display a shortened snout (J:42035)
• at birth, homozygotes display a shortened snout (J:42035)
• at birth, homozygotes display a shortened head (J:42035)
• at birth, homozygotes display a shortened head (J:42035)

respiratory system
• newborns exhibit gasping respirations prior to death and contain air in their stomachs and intestines (J:42035)
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes contain less air in their stomachs than homozygotes on a mixed genetic background (J:42035)
• newborns exhibit gasping respirations prior to death and contain air in their stomachs and intestines (J:42035)
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes contain less air in their stomachs than homozygotes on a mixed genetic background (J:42035)

homeostasis/metabolism
• newborn homozygotes become rapidly cyanotic (J:42035)
• newborn homozygotes become rapidly cyanotic (J:42035)

skeleton
• at birth, homozygotes exhibit a rounded skull (J:42035)
• at birth, homozygotes exhibit a rounded skull (J:42035)
• newborn homozygotes lack alveolar processes (J:42035)
• newborn homozygotes lack alveolar processes (J:42035)
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin (J:42035)
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin (J:42035)
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities (J:42035)
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities (J:42035)

digestive/alimentary system
• at ~E13, the shape of the secondary palate is slightly altered (J:42035)
• at ~E13, the shape of the secondary palate is slightly altered (J:42035)
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)

hearing/vestibular/ear
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities (J:42035)
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities (J:42035)

limbs/digits/tail
N
• surprisingly, homozygotes exhibit no limb defects (J:42035)
• surprisingly, homozygotes exhibit no limb defects (J:42035)

growth/size/body
• molars develop until E13.5 and reach the bud stage but fail to develop further (J:42035)
• molars develop until E13.5 and reach the bud stage but fail to develop further (J:42035)
• at ~E13, the shape of the secondary palate is slightly altered (J:42035)
• at ~E13, the shape of the secondary palate is slightly altered (J:42035)
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• newborn homozygotes lack incisors (J:42035)
• newborn homozygotes lack incisors (J:42035)
• at P0, homozygotes lack mandibular molars (J:104286)
• at P0, homozygotes lack mandibular molars (J:104286)
• at birth, homozygotes display a shortened snout (J:42035)
• at birth, homozygotes display a shortened snout (J:42035)
• at birth, homozygotes display a shortened head (J:42035)
• at birth, homozygotes display a shortened head (J:42035)

Mouse Models of Human Disease
OMIM ID Ref(s)
Tooth Agenesis, Selective, 1; STHAG1 106600 J:42035




Genotype
MGI:3607401
hm2
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E13.5 homozygotes have significantly more Gnrh1 expressing neurons (1300+/-116) compared to wild-type (939+/-20) and some of these cells are ectopically located in the olfactory epithelium (J:99936)
• at E13.5 homozygotes have significantly more Gnrh1 expressing neurons (1300+/-116) compared to wild-type (939+/-20) and some of these cells are ectopically located in the olfactory epithelium (J:99936)




Genotype
MGI:2676083
hm3
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• a normal roof plate fails to form in the caudal diencephalon as indicated by marker analysis (J:84975)
• a normal roof plate fails to form in the caudal diencephalon as indicated by marker analysis (J:84975)
• 1/3 of E11.5 mutants exhibit an indentation at the boundary between the diencephalon and mesencephalon (J:84975)
• 1/3 of E11.5 mutants exhibit an indentation at the boundary between the diencephalon and mesencephalon (J:84975)
• the subcommissural organ is reduced or absent in all mutants at E15.5 (J:84975)
• the subcommissural organ is colonized by many nucleated cells instead of mainly neural fibers (J:84975)
• the subcommissural organ is reduced or absent in all mutants at E15.5 (J:84975)
• the subcommissural organ is colonized by many nucleated cells instead of mainly neural fibers (J:84975)
• some mutants exhibit hydrocephalus at birth (J:84975)
• some mutants exhibit hydrocephalus at birth (J:84975)
• seen in some mutants (J:84975)
• seen in some mutants (J:84975)
• posterior commissure is disorganized at E15.5 (J:84975)
• posterior commissure is disorganized at E15.5 (J:84975)
• marker analysis indicates that dorsal midline cells are not maintained in prosomere 1 of the diencephalon (J:84975)
• cell death is reduced in the dorsal midline of the diencephalon of E10.5-E12.5 mutants (J:84975)
• marker analysis indicates that dorsal midline cells are not maintained in prosomere 1 of the diencephalon (J:84975)
• cell death is reduced in the dorsal midline of the diencephalon of E10.5-E12.5 mutants (J:84975)
• seen in some mutants (J:84975)
• seen in some mutants (J:84975)

endocrine/exocrine glands
• the subcommissural organ is reduced or absent in all mutants at E15.5 (J:84975)
• the subcommissural organ is colonized by many nucleated cells instead of mainly neural fibers (J:84975)
• the subcommissural organ is reduced or absent in all mutants at E15.5 (J:84975)
• the subcommissural organ is colonized by many nucleated cells instead of mainly neural fibers (J:84975)

embryogenesis
• a normal roof plate fails to form in the caudal diencephalon as indicated by marker analysis (J:84975)
• a normal roof plate fails to form in the caudal diencephalon as indicated by marker analysis (J:84975)




Genotype
MGI:5473567
ht4
Allelic
Composition
Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx1tm2.1(cre/ERT2)Bero mutation (2 available); any Msx1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryogenesis
• internal organ development is disrupted due to thoracoabdominoschisis (J:194129)
• internal organ development is disrupted due to thoracoabdominoschisis (J:194129)

growth/size/body
• at E12.5, embryos have highly deformed faces (J:194129)
• at E12.5, embryos have highly deformed faces (J:194129)
• at E12.3 embryos show thoracoabdominoschisis (opening of both the thorax and abdomen) (J:194129)
• at E12.3 embryos show thoracoabdominoschisis (opening of both the thorax and abdomen) (J:194129)

craniofacial
• at E12.5, embryos have highly deformed faces (J:194129)
• at E12.5, embryos have highly deformed faces (J:194129)

nervous system
• at E12.5 (J:194129)
• at E12.5 (J:194129)

liver/biliary system
• liver appears rudimentary (J:194129)
• liver appears rudimentary (J:194129)

vision/eye
• embryos display atrophic eyes at E12.5 (J:194129)
• embryos display atrophic eyes at E12.5 (J:194129)




Genotype
MGI:5297709
cn5
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Bero mutation (0 available); any Msx2 mutation (15 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (15 available)
Taglntm2(cre)Yec mutation (1 available); any Tagln mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• superficial temporal artery is more branched than in controls (J:173525)
• superficial temporal artery is more branched than in controls (J:173525)
• at E11.5, carotid artery (CA) overbranching is observed (J:173525)
• at E11.5, carotid artery (CA) overbranching is observed (J:173525)
• vertebral artery (VA) caliber is increased relative to controls (J:173525)
• vertebral artery (VA) caliber is increased relative to controls (J:173525)
• number of smooth muscle actin-positive cells in CA is half that observed in controls (J:173525)
• number of smooth muscle actin-positive cells in CA is half that observed in controls (J:173525)
• in the head, aneurysms are frequently observed (J:173525)
• in the head, aneurysms are frequently observed (J:173525)
• in the head, hemorrhages are frequently observed (J:173525)
• in the head, hemorrhages are frequently observed (J:173525)

muscle
• number of smooth muscle actin-positive cells in CA is half that observed in controls (J:173525)
• number of smooth muscle actin-positive cells in CA is half that observed in controls (J:173525)

nervous system
• in the head, hemorrhages are frequently observed (J:173525)
• in the head, hemorrhages are frequently observed (J:173525)




Genotype
MGI:5297713
cn6
Allelic
Composition
Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Yvla/Msx2tm1Yvla
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx1tm2.1(cre/ERT2)Bero mutation (2 available); any Msx1 mutation (8 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased carotid artery vessel diameter is observed (J:173525)
• increased carotid artery vessel diameter is observed (J:173525)
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed (J:173525)
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed (J:173525)

muscle
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed (J:173525)
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed (J:173525)




Genotype
MGI:5613192
cx7
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Bero mutation (0 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at E9.5 - E11.5 (J:208848)
• at E9.5 - E11.5 (J:208848)

embryogenesis
• at E9.5 - E11.5 (J:208848)
• at E9.5 - E11.5 (J:208848)
• expression analysis indicates that the dorsal progenitor pool 1 cells are not specified and that the proportion of dorsal progenitor 3 cells is increased at E10.5 (J:208848)
• expression analysis indicates that the dorsal progenitor pool 1 cells are not specified and that the proportion of dorsal progenitor 3 cells is increased at E10.5 (J:208848)

nervous system
• expression analysis indicates that the dorsal progenitor pool 1 cells are not specified and that the proportion of dorsal progenitor 3 cells is increased at E10.5 (J:208848)
• expression analysis indicates that the dorsal progenitor pool 1 cells are not specified and that the proportion of dorsal progenitor 3 cells is increased at E10.5 (J:208848)
• at E9.5 - E11.5 (J:208848)
• at E9.5 - E11.5 (J:208848)




Genotype
MGI:2676082
cx8
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Bero mutation (0 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• resorption observed at E10.5 and E11.5, incomplete penetrance (J:84975)
• resorption observed at E10.5 and E11.5, incomplete penetrance (J:84975)

embryogenesis
• small embryo size at E10.5-E11.5 (J:84975)
• small embryo size at E10.5-E11.5 (J:84975)
• seen in some embryos (J:84975)
• seen in some embryos (J:84975)

growth/size/body
• small embryo size at E10.5-E11.5 (J:84975)
• small embryo size at E10.5-E11.5 (J:84975)

nervous system
• seen in some embryos (J:84975)
• seen in some embryos (J:84975)
• observed in some cases, encompassing the posterior mesencephalon and the rhombencephalon (J:84975)
• observed in some cases, encompassing the posterior mesencephalon and the rhombencephalon (J:84975)
• small and abnormal brain (J:84975)
• small and abnormal brain (J:84975)




Genotype
MGI:3797245
cx9
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Genetic
Background
involves: 129/Sv * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Bero mutation (0 available); any Msx2 mutation (15 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial

digestive/alimentary system

growth/size/body




Genotype
MGI:3582224
cx10
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
Genetic
Background
involves: 129/Sv * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Bero mutation (0 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygotes do not survive beyond E15 (J:98917)
• double homozygotes do not survive beyond E15 (J:98917)

limbs/digits/tail
• maturation of the apical ectodermal ridge is impaired and regression is delayed; however initiation is normal (J:98917)
• at E10.2 and E11.5 the apical ectodermal ridge appears shorter and more diffuse (J:98917)
• at E12.5 the apical ectodermal ridge remains continuos along the entire apex of the limb and appears thicker than normal (J:98917)
• maturation of the apical ectodermal ridge is impaired and regression is delayed; however initiation is normal (J:98917)
• at E10.2 and E11.5 the apical ectodermal ridge appears shorter and more diffuse (J:98917)
• at E12.5 the apical ectodermal ridge remains continuos along the entire apex of the limb and appears thicker than normal (J:98917)
• limb bud size is reduced by about 1/3 at E10.5 to E11.5 even in somite-matched embryos (J:98917)
• the mesenchymal anterior domain of the limb bud is not maintained after E10.5 and all of the mesenchyme in the limb bud assumes a posterior identity (J:98917)
• in the anterior portion of the limb bud the normal dorsal ventral boundary is not established at E10.5 (J:98917)
• limb bud size is reduced by about 1/3 at E10.5 to E11.5 even in somite-matched embryos (J:98917)
• the mesenchymal anterior domain of the limb bud is not maintained after E10.5 and all of the mesenchyme in the limb bud assumes a posterior identity (J:98917)
• in the anterior portion of the limb bud the normal dorsal ventral boundary is not established at E10.5 (J:98917)
• at E14.5 about ? of mutants only have 1 phalange while control embryos have 2 (J:98917)
• the missing digit is always the anterior most one (J:98917)
• at E14.5 about ? of mutants only have 1 phalange while control embryos have 2 (J:98917)
• the missing digit is always the anterior most one (J:98917)
• 2 out of 18 mutant forelimbs had 6 digits (J:98917)
• 2 out of 18 mutant forelimbs had 6 digits (J:98917)
• at E14.5 interdigital webbing is retained (J:98917)
• at E14.5 interdigital webbing is retained (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• at E14.5 the 3 segments of the limb are about 3/4 of the normal size (J:98917)
• general truncation of the anterior parts of the limbs with systematic loss of the anterior part of the zeugopod (J:98917)
• at E14.5 the 3 segments of the limb are about 3/4 of the normal size (J:98917)
• general truncation of the anterior parts of the limbs with systematic loss of the anterior part of the zeugopod (J:98917)

embryogenesis
• maturation of the apical ectodermal ridge is impaired and regression is delayed; however initiation is normal (J:98917)
• at E10.2 and E11.5 the apical ectodermal ridge appears shorter and more diffuse (J:98917)
• at E12.5 the apical ectodermal ridge remains continuos along the entire apex of the limb and appears thicker than normal (J:98917)
• maturation of the apical ectodermal ridge is impaired and regression is delayed; however initiation is normal (J:98917)
• at E10.2 and E11.5 the apical ectodermal ridge appears shorter and more diffuse (J:98917)
• at E12.5 the apical ectodermal ridge remains continuos along the entire apex of the limb and appears thicker than normal (J:98917)
• limb bud size is reduced by about 1/3 at E10.5 to E11.5 even in somite-matched embryos (J:98917)
• the mesenchymal anterior domain of the limb bud is not maintained after E10.5 and all of the mesenchyme in the limb bud assumes a posterior identity (J:98917)
• in the anterior portion of the limb bud the normal dorsal ventral boundary is not established at E10.5 (J:98917)
• limb bud size is reduced by about 1/3 at E10.5 to E11.5 even in somite-matched embryos (J:98917)
• the mesenchymal anterior domain of the limb bud is not maintained after E10.5 and all of the mesenchyme in the limb bud assumes a posterior identity (J:98917)
• in the anterior portion of the limb bud the normal dorsal ventral boundary is not established at E10.5 (J:98917)

skeleton
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• the posterior elements are present, the medium elements are severely truncated, and the anterior elements are absent (J:98917)
• at E14.5 the scapula is about 3/4 of the normal size (J:98917)
• at E14.5 the scapula is about 3/4 of the normal size (J:98917)
• at E14.5 the pelvic girdle is about 3/4 of the normal size (J:98917)
• at E14.5 the pelvic girdle is about 3/4 of the normal size (J:98917)
• mutants lack the pubis bone corresponding to the anterior part of the pelvis (J:98917)
• mutants lack the pubis bone corresponding to the anterior part of the pelvis (J:98917)




Genotype
MGI:3797244
cx11
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Yvla/Msx2tm1Yvla
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond E14.5 (J:136241)
• mice do not survive beyond E14.5 (J:136241)

craniofacial
• mice exhibit craniofacial malformations (J:136241)
• mice exhibit craniofacial malformations (J:136241)

limbs/digits/tail
• mice exhibit limb malformations (J:136241)
• mice exhibit limb malformations (J:136241)

nervous system

growth/size/body
• thoracoabdominoschisis (J:136241)
• thoracoabdominoschisis (J:136241)




Genotype
MGI:3702326
cx12
Allelic
Composition
Dlx5tm1Levi/Dlx5tm1Levi
Msx1tm1Bero/Msx1tm1Bero
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5tm1Levi mutation (1 available); any Dlx5 mutation (8 available)
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygotes die soon after delivery (J:104286)
• double homozygotes die soon after delivery (J:104286)

craniofacial
• at P0, double homozygotes exhibit severe retardation of mineralized bone deposition in calvaria (J:104286)
• at P0, double mutant vault bones are smaller and severely perforated with irregular borders relative to those seen in either single homozygote (J:104286)
• at P0, double homozygotes exhibit severe retardation of mineralized bone deposition in calvaria (J:104286)
• at P0, double mutant vault bones are smaller and severely perforated with irregular borders relative to those seen in either single homozygote (J:104286)
• at P0, double homozygotes display deformed basioccipitals, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed basioccipitals, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed basisphenoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed basisphenoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double mutant fontanels appear to be open on the midline (J:104286)
• at P0, double mutant fontanels appear to be open on the midline (J:104286)
• at P0, double homozygotes display a disorganized foramina of the ala temporalis, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a disorganized foramina of the ala temporalis, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed pterygoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed pterygoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed squamosal bones, similar to Msx1tm1Bero homozygotes (J:104286)
• at P0, double homozygotes display deformed squamosal bones, similar to Msx1tm1Bero homozygotes (J:104286)
• at P0, double homozygotes lack the coronoid process, similar to single Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes lack the coronoid process, similar to single Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a shorter and coarser jaw relative to wild-type or to Msx1tm1Bero homozygotes, although not as short as in Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a shorter and coarser jaw relative to wild-type or to Msx1tm1Bero homozygotes, although not as short as in Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a malformed malleus with no head, similar to Msx1tm1Bero homozygotes (J:104286)
• in addition, an ectopic bone is present, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a malformed malleus with no head, similar to Msx1tm1Bero homozygotes (J:104286)
• in addition, an ectopic bone is present, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display absence of caput mallei (J:104286)
• at P0, double homozygotes display absence of caput mallei (J:104286)
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at E13.5, double homozygotes (2/2) display partly formed and elevated shelves which fail to come to contact and fuse (J:104286)
• at P0, double homozygotes (3/3) exhibit a mild clefting, as elevated shelves fail to fuse in the midline, indicating partial rescue of the severe Msx1-related palatal phenotype (J:104286)
• at E13.5, double homozygotes (2/2) display partly formed and elevated shelves which fail to come to contact and fuse (J:104286)
• at P0, double homozygotes (3/3) exhibit a mild clefting, as elevated shelves fail to fuse in the midline, indicating partial rescue of the severe Msx1-related palatal phenotype (J:104286)
• at P0, double homozygotes lack molar teeth, similar to Msx1tm1Bero homozygotes (J:104286)
• at P0, double homozygotes lack molar teeth, similar to Msx1tm1Bero homozygotes (J:104286)

digestive/alimentary system
• at E13.5, double homozygotes (2/2) display partly formed and elevated shelves which fail to come to contact and fuse (J:104286)
• at P0, double homozygotes (3/3) exhibit a mild clefting, as elevated shelves fail to fuse in the midline, indicating partial rescue of the severe Msx1-related palatal phenotype (J:104286)
• at E13.5, double homozygotes (2/2) display partly formed and elevated shelves which fail to come to contact and fuse (J:104286)
• at P0, double homozygotes (3/3) exhibit a mild clefting, as elevated shelves fail to fuse in the midline, indicating partial rescue of the severe Msx1-related palatal phenotype (J:104286)

skeleton
• at P0, double homozygotes exhibit severe retardation of mineralized bone deposition in calvaria (J:104286)
• at P0, double mutant vault bones are smaller and severely perforated with irregular borders relative to those seen in either single homozygote (J:104286)
• at P0, double homozygotes exhibit severe retardation of mineralized bone deposition in calvaria (J:104286)
• at P0, double mutant vault bones are smaller and severely perforated with irregular borders relative to those seen in either single homozygote (J:104286)
• at P0, double homozygotes display deformed basioccipitals, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed basioccipitals, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed basisphenoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed basisphenoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double mutant fontanels appear to be open on the midline (J:104286)
• at P0, double mutant fontanels appear to be open on the midline (J:104286)
• at P0, double homozygotes display a disorganized foramina of the ala temporalis, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a disorganized foramina of the ala temporalis, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed pterygoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed pterygoids, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display deformed squamosal bones, similar to Msx1tm1Bero homozygotes (J:104286)
• at P0, double homozygotes display deformed squamosal bones, similar to Msx1tm1Bero homozygotes (J:104286)
• at P0, double homozygotes lack the coronoid process, similar to single Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes lack the coronoid process, similar to single Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a shorter and coarser jaw relative to wild-type or to Msx1tm1Bero homozygotes, although not as short as in Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a shorter and coarser jaw relative to wild-type or to Msx1tm1Bero homozygotes, although not as short as in Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a malformed malleus with no head, similar to Msx1tm1Bero homozygotes (J:104286)
• in addition, an ectopic bone is present, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a malformed malleus with no head, similar to Msx1tm1Bero homozygotes (J:104286)
• in addition, an ectopic bone is present, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display absence of caput mallei (J:104286)
• at P0, double homozygotes display absence of caput mallei (J:104286)
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double hoomozygotes display delayed fore- and hindlimb ossification and a severe retardation of mineralized bone deposition in calvaria; only slight to mild delays are noted in single homozygotes (J:104286)
• at P0, double hoomozygotes display delayed fore- and hindlimb ossification and a severe retardation of mineralized bone deposition in calvaria; only slight to mild delays are noted in single homozygotes (J:104286)

hearing/vestibular/ear
• at P0, double homozygotes display a malformed malleus with no head, similar to Msx1tm1Bero homozygotes (J:104286)
• in addition, an ectopic bone is present, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display a malformed malleus with no head, similar to Msx1tm1Bero homozygotes (J:104286)
• in addition, an ectopic bone is present, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display absence of caput mallei (J:104286)
• at P0, double homozygotes display absence of caput mallei (J:104286)
• at birth, the vestibular portion of the otic capsule is always malformed, similar to Dlx5tm1Levi homozygotes (J:104286)
• at birth, the vestibular portion of the otic capsule is always malformed, similar to Dlx5tm1Levi homozygotes (J:104286)

respiratory system
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)

growth/size/body
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at P0, double homozygotes display hypoplasia and asymmetry of the nasal capsules, similar to Dlx5tm1Levi homozygotes (J:104286)
• at E13.5, double homozygotes (2/2) display partly formed and elevated shelves which fail to come to contact and fuse (J:104286)
• at P0, double homozygotes (3/3) exhibit a mild clefting, as elevated shelves fail to fuse in the midline, indicating partial rescue of the severe Msx1-related palatal phenotype (J:104286)
• at E13.5, double homozygotes (2/2) display partly formed and elevated shelves which fail to come to contact and fuse (J:104286)
• at P0, double homozygotes (3/3) exhibit a mild clefting, as elevated shelves fail to fuse in the midline, indicating partial rescue of the severe Msx1-related palatal phenotype (J:104286)
• at P0, double homozygotes lack molar teeth, similar to Msx1tm1Bero homozygotes (J:104286)
• at P0, double homozygotes lack molar teeth, similar to Msx1tm1Bero homozygotes (J:104286)




Genotype
MGI:5307914
cx13
Allelic
Composition
Barx1tm1Shiv/Barx1tm1Shiv
Msx1tm1Bero/Msx1+
Genetic
Background
involves: 129P2/OlaHsd * various
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Barx1tm1Shiv mutation (0 available); any Barx1 mutation (1 available)
Msx1tm1Bero mutation (1 available); any Msx1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• permanent in molars at the bud stage (J:180393)
• permanent in molars at the bud stage (J:180393)

growth/size/body
• permanent in molars at the bud stage (J:180393)
• permanent in molars at the bud stage (J:180393)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory