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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hesx1tm1Icar
targeted mutation 1, Iain C A F Robinson
MGI:1931124
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hesx1tm1Icar/Hesx1tm1Icar involves: 129P2/OlaHsd MGI:3711468
hm2
Hesx1tm1Icar/Hesx1tm1Icar involves: 129P2/OlaHsd * C57BL/6 MGI:2175062
ht3
Hesx1tm1Icar/Hesx1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3766120
ht4
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar involves: 129P2/OlaHsd * 129S/SvEv MGI:5314531
ht5
Hesx1tm1Icar/Hesx1tm2Jpmb involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N MGI:3822780
ht6
Hesx1tm1Icar/Hesx1tm3Jpmb involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N MGI:3822896
cn7
Ctnnb1tm2Kem/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:5314537
cn8
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3822771
cn9
Ctnnb1tm1Max/Ctnnb1tm2Kem
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:5314536
cx10
Hesx1tm1Icar/Hesx1+
Tcf7l1tm2Efu/Tcf7l1+
involves: 129P2/OlaHsd * 129S/SvEv MGI:5314532
cx11
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Tcf7l1tm2Efu/Tcf7l1+
involves: 129P2/OlaHsd * 129S/SvEv MGI:5314533
cx12
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:5314535
cx13
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1Icar/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:5314538


Genotype
MGI:3711468
hm1
Allelic
Composition
Hesx1tm1Icar/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice

nervous system




Genotype
MGI:2175062
hm2
Allelic
Composition
Hesx1tm1Icar/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most severely affected pups only die shortly after birth
• 75% of mice dead by 3 weeks

nervous system
• the vomeronasal organs are reduced
• at E11.5 and E12.5, in mildly affected mice the neuroepithelium is thin compared to in wild-type and heterozygous mice
• at E12.5, in severely affected mice Rathke's pouch is absent
• all mice display defects in Rathke's pouch such that it is abnormally bifurcated
• the anterior lobe of the pituitary is smaller than in wild-type mice and less intimately associated with the posterior lobe
• at E12.5, severely affected mice display no sign of infundibulum development
• at E8.5, prospective forebrain tissue is reduced
• forebrain defects are variable between hemispheres and mice
• at E12.5, severely affected mice display reduced forebrain size with no sign of telencephalic vesicles
• nerve fibers are present but fail to cross the midline
• defects are more pronouced on one side of the mice than the other
• many mice display a disruption of left-right asymmetry of the telecephalic vessicle, eye, and olfactory placode
• severely affected mice (5%) lack or exhbit a reduction in telencephalic vesicles, olfactory placodes and frontonasal mass (J:47920)
• at E11.5 and E12.5, mildly affected mice display reduced telencephalic vesicles (J:47920)
• however, mildly affected mice exhibit normal medial and lateral ganglionic eminences (J:47920)
• telencephalic vesicles are reduced in size at 12.5 dpc (J:142649)
• at 9.5 dpc (days post coitum), elevated apoptosis is observed relative to wild-type at level of midbrain-hindbrain boundary
• forebrain reduction is variable depending on the severity of phenotype (J:47920)
• at E12.5, severely affected mice display reduced forebrain size with no sign of telencephalic vesicles (J:47920)
• reduction of anterior forebrain (AFB) tissue is detected at 8- to 10-somite (8.5 dpc) stage, based upon expression of markers Six3, Pax2, Pax6 and Fgf8 (J:135132)
• at presomitic stages, expression domains of these markers are identical to controls (J:135132)
• the dorsal and ventral hippocampal commissures are absent in 2 of 3 mice that also lacked the anterior commissure and the corpus callosum
• absent in 3 of 4 mice
• all mice display ventral midline defects in the hypothalamus with the floor of the hypothalamus is expanded
• telencephalic midline structures are abnormal (J:47920)
• cell death in roof plate of telencephalon is reduced compared to normal littermates at 9.5 dpc (J:135132)
• in 3 of 4 mice
• the olfactory bulbs are hypoplastic and lack glomerular and mitral cell layers
• in 25% of mice the septum pellucidum is missing

respiratory system
• mice display hypoplastic and frequently asymmetric olfactory pits
• severely affected mice (5%) lack or exhbit a reductin in telencephalic vesicles, olfactory placodes and frontonasal mass
• many mice display a disruption of left-right asymmetry of the telecephalic vessicle, eye, and olfactory placode
• at E12.5, in severely affected mice the olfactory placodes are absent
• the nasal cavitis are hypoplastic and the olfactory epithelium at the rostral extreme of the cavities is aplastic
• the vomeronasal organs are reduced
• the olfactory epithelium at the rostral extreme of the nasal cavities is aplastic
• however, caudal epithelium is normal

vision/eye
• at birth, severely affected mice display absent or micropthalamic eyes
• mildly affected mice display abnormal eye morphology in only one eye
• at E12.5, in severely affected mice the optic cup and ectodermal derivatives such as the optic lenses, olfactory placodes and Rathke's pouch are absent
• the optic vesicles are hypoplastic and frequently assymetric
• when eyes are present, they are located more posteriorly than in wild-type mice and remain buried in the orbit
• at birth, severely affected mice display absent or micropthalamic eyes
• at birth, severely affected mice display absent or micropthalamic eyes (J:47920)
• embryos lack eyes at 12.5 days post coitum (dpc) (J:142649)

craniofacial
• mildly affected mice display craniofacial dysplasia
• frontonasal mass development is impaired by 12.5 dpc
• mice display hypoplastic and frequently asymmetric olfactory pits
• severely affected mice (5%) lack or exhbit a reductin in telencephalic vesicles, olfactory placodes and frontonasal mass
• many mice display a disruption of left-right asymmetry of the telecephalic vessicle, eye, and olfactory placode
• at E12.5, in severely affected mice the olfactory placodes are absent
• the nasal cavitis are hypoplastic and the olfactory epithelium at the rostral extreme of the cavities is aplastic
• the vomeronasal organs are reduced
• the olfactory epithelium at the rostral extreme of the nasal cavities is aplastic
• however, caudal epithelium is normal
• at birth, severely affected mice display small head size, short nose and absent or micropthalamic eyes

hearing/vestibular/ear
• at E8.5, mice lack otic vesicles

taste/olfaction
• severely affected mice (5%) lack or exhbit a reductin in telencephalic vesicles, olfactory placodes and frontonasal mass
• many mice display a disruption of left-right asymmetry of the telecephalic vessicle, eye, and olfactory placode
• at E12.5, in severely affected mice the olfactory placodes are absent
• the olfactory epithelium at the rostral extreme of the nasal cavities is aplastic
• however, caudal epithelium is normal

endocrine/exocrine glands
• at E12.5, in severely affected mice Rathke's pouch is absent
• all mice display defects in Rathke's pouch such that it is abnormally bifurcated
• the anterior lobe of the pituitary is smaller than in wild-type mice and less intimately associated with the posterior lobe
• at E12.5, severely affected mice display no sign of infundibulum development

embryo
• at E11.5 and E12.5, in mildly affected mice the neuroepithelium is thin compared to in wild-type and heterozygous mice

growth/size/body
• the nasal cavitis are hypoplastic and the olfactory epithelium at the rostral extreme of the cavities is aplastic
• the vomeronasal organs are reduced
• the olfactory epithelium at the rostral extreme of the nasal cavities is aplastic
• however, caudal epithelium is normal
• at birth, severely affected mice display small head size, short nose and absent or micropthalamic eyes
• at birth, severely affected mice display small head size, short nose and absent or micropthalamic eyes




Genotype
MGI:3766120
ht3
Allelic
Composition
Hesx1tm1Icar/Hesx1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 1% of mice exhibit the mild phenotype associated with homozygous mice

respiratory system
• 1% of mice exhibit the mild phenotype associated with homozygous mice

vision/eye
• 1% of mice exhibit the mild phenotype associated with homozygous mice

craniofacial
• 1% of mice exhibit the mild phenotype associated with homozygous mice
• 1% of mice exhibit the mild phenotype associated with homozygous mice

growth/size/body
• 1% of mice exhibit the mild phenotype associated with homozygous mice




Genotype
MGI:5314531
ht4
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• partial penetrance and displayed a variable range of anterior defects
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice
• bilateral in some mice

nervous system




Genotype
MGI:3822780
ht5
Allelic
Composition
Hesx1tm1Icar/Hesx1tm2Jpmb
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm2Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 26% of embryos analyzed show reduced telencephalic tissue at 12.5-14.5 dpc (days post coitum)
• severity and frequency of forebrain defects are increased in double heterozygotes, due to Hesx1 dosage decrease

vision/eye
• all embryos analyzed display severe bilateral microphthalmia or anophthalmia between 12.5 and 14.5 dpc
• some affected embryos also show reduction in telencephalic tissue
• all embryos analyzed display severe bilateral microphthalmia or anophthalmia between 12.5 and 14.5 dpc
• some affected embryos also show reduction in telencephalic tissue




Genotype
MGI:3822896
ht6
Allelic
Composition
Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm3Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• phenotype is stated to be identical to that of Hesx1tm1Icar homozygotes; however no data are presented
• severity of defects is similar to that seen in Hesx1tm3Jpmb homozygotes




Genotype
MGI:5314537
cn7
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (41 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

vision/eye
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice




Genotype
MGI:3822771
cn8
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• telencepepahlic vesicle development is often asymmetric in embryos, with the right side being more severely affected
• very small telencephalic vesicle is sometimes observed at the 8-10 somite stage

vision/eye
• development of optic vesicles is often asymmetric with right side more severely affected




Genotype
MGI:5314536
cn9
Allelic
Composition
Ctnnb1tm1Max/Ctnnb1tm2Kem
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation (0 available); any Ctnnb1 mutation (41 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (41 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• unilateral in some mice
• bilateral in some mice
• unilateral in some mice

nervous system




Genotype
MGI:5314532
cx10
Allelic
Composition
Hesx1tm1Icar/Hesx1+
Tcf7l1tm2Efu/Tcf7l1+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
Tcf7l1tm2Efu mutation (0 available); any Tcf7l1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• unilateral in some mice
• bilateral in some mice
• unilateral in some mice

nervous system




Genotype
MGI:5314533
cx11
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Tcf7l1tm2Efu/Tcf7l1+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
Tcf7l1tm2Efu mutation (0 available); any Tcf7l1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• almost complete loss of most of the anterior forebrain




Genotype
MGI:5314535
cx12
Allelic
Composition
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation (0 available); any Ctnnb1 mutation (41 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

vision/eye
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice




Genotype
MGI:5314538
cx13
Allelic
Composition
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1Icar/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation (0 available); any Ctnnb1 mutation (41 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

vision/eye
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory