Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Sia mutation
(10 available);
any
Trp53 mutation
(232 available)
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neoplasm
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• tumors develop in all mice at 3 to 6 months of age
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• most tumors (>90%) are T cell lymphomas
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cellular
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• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs
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• MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs
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• several cell types, including lens epithelial cells, show enhanced proliferation (doubling potential) in culture compared to wild-type cells
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endocrine/exocrine glands
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• most tumors (>90%) are T cell lymphomas
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Sia mutation
(10 available);
any
Trp53 mutation
(232 available)
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mortality/aging
neoplasm
hematopoietic system
growth/size/body
endocrine/exocrine glands
immune system
neoplasm
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• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 100% of mice, while uninjected mice or injected Ryr2 homozygous, Trp53-sufficient mice (~wild-type) do not develop tumors even after 15 weeks
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• tumors are of this type
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immune system
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• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not
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muscle
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• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not
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• tumors are of this type
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mortality/aging
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• earlier tumor induced death
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neoplasm
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• 96% develop tumors by 299 days of age compared to 56% of mice only homozygous for Trp53tm1Sia
• greater frequency of multiple tumors
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eloatm1Aso mutation
(0 available);
any
Eloa mutation
(22 available)
Trp53tm1Sia mutation
(10 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• died at between 10.5 and 12.5 of gestation
• similar to phenotype found in Tceb3tm1Aso homozygous embryos
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embryo
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• in live E10.5 embryos
• similar to phenotype found in Tceb3tm1Aso homozygous embryos
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• in live E10.5 embryos
• morphologically not distinguishable from Tceb3tm1Aso homozygous embryos
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growth/size/body
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• in live E10.5 embryos
• morphologically not distinguishable from Tceb3tm1Aso homozygous embryos
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cellular
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• in live E10.5 embryos
• similar to phenotype found in Tceb3tm1Aso homozygous embryos
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neoplasm
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• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 40% of mice
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• tumors are of this type
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muscle
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• tumors are of this type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Puf60tm1.1Kmtsu mutation
(0 available);
any
Puf60 mutation
(30 available)
Trp53tm1Sia mutation
(10 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• unlike Trp53tm1Sia homozygotes
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reproductive system
neoplasm
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• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53tm1Sia homozygotes
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• increased bone marrow invasion compared with Trp53tm1Sia homozygotes
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hematopoietic system
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• more so than in Trp53tm1Sia homozygotes
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• more so than in Trp53tm1Sia homozygotes
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• more so than in Trp53tm1Sia homozygotes
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growth/size/body
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• more so than in Trp53tm1Sia homozygotes
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endocrine/exocrine glands
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• more so than in Trp53tm1Sia homozygotes
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• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53tm1Sia homozygotes
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respiratory system
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• with a loss of movement at time of sacrifice
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immune system
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• more so than in Trp53tm1Sia homozygotes
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• more so than in Trp53tm1Sia homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r13btm1Suda mutation
(0 available);
any
Ppp1r13b mutation
(53 available)
Trp53tm1Sia mutation
(10 available);
any
Trp53 mutation
(232 available)
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immune system
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• collecting lymphatic vessels along both side of the ischiatic vein were missing and appeared tortuous, distended, or fused to form single vessels in adult homozygous mice
• this phenotype is not enhanced or suppressed by presence of Trp53tm1Sia mutation as compared to Ppp1r13btm1Suda homozygous mice
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