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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:1926340
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp53tm1Sia/Trp53tm1Sia involves: C57BL/6 * CBA MGI:2174781
cn2
Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs
Trp53tm1Sia/Trp53tm1Sia
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3698871
cx3
Eloatm1Aso/Eloatm1Aso
Trp53tm1Sia/Trp53tm1Sia
involves: 129S/SvEv * C57BL/6 * CBA MGI:3704887
cx4
Irf1tm1Mak/Irf1tm1Mak
Trp53tm1Sia/Trp53tm1Sia
involves: 129S2/SvPas * C57BL/6 * CBA MGI:4819238
cx5
Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs
Trp53tm1Sia/Trp53+
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3698873
cx6
Ppp1r13btm1Suda/Ppp1r13btm1Suda
Trp53tm1Sia/Trp53tm1Sia
involves: various MGI:3801105


Genotype
MGI:2174781
hm1
Allelic
Composition
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• most tumors (>90%) are T cell lymphomas

neoplasm
• tumors develop in all mice at 3 to 6 months of age
• most tumors (>90%) are T cell lymphomas

cellular
• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs
• MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs
• several cell types, including lens epithelial cells, show enhanced proliferation (doubling potential) in culture compared to wild-type cells




Genotype
MGI:3698871
cn2
Allelic
Composition
Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs mutation (2 available); any Ryr2 mutation (39 available)
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 100% of mice, while uninjected mice or injected Ryr2 homozygous, Trp53-sufficient mice (~wild-type) do not develop tumors even after 15 weeks
• tumors are of this type

immune system
• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not

muscle
• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not
• tumors are of this type




Genotype
MGI:3704887
cx3
Allelic
Composition
Eloatm1Aso/Eloatm1Aso
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eloatm1Aso mutation (0 available); any Eloa mutation (2 available)
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died at between 10.5 and 12.5 of gestation
• similar to phenotype found in Tceb3tm1Aso homozygous embryos

embryo
• in live E10.5 embryos
• similar to phenotype found in Tceb3tm1Aso homozygous embryos
• in live E10.5 embryos
• morphologically not distinguishable from Tceb3tm1Aso homozygous embryos

growth/size/body
• in live E10.5 embryos
• morphologically not distinguishable from Tceb3tm1Aso homozygous embryos

cellular
• in live E10.5 embryos
• similar to phenotype found in Tceb3tm1Aso homozygous embryos




Genotype
MGI:4819238
cx4
Allelic
Composition
Irf1tm1Mak/Irf1tm1Mak
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf1tm1Mak mutation (1 available); any Irf1 mutation (7 available)
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• earlier tumor induced death

neoplasm
• 96% develop tumors by 299 days of age compared to 56% of mice only homozygous for Trp53tm1Sia
• greater frequency of multiple tumors
• immature teratomas




Genotype
MGI:3698873
cx5
Allelic
Composition
Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs
Trp53tm1Sia/Trp53+
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs mutation (2 available); any Ryr2 mutation (39 available)
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• tumors are of this type

neoplasm
• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 40% of mice
• tumors are of this type




Genotype
MGI:3801105
cx6
Allelic
Composition
Ppp1r13btm1Suda/Ppp1r13btm1Suda
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background
involves: various
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r13btm1Suda mutation (0 available); any Ppp1r13b mutation (5 available)
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• collecting lymphatic vessels along both side of the ischiatic vein were missing and appeared tortuous, distended, or fused to form single vessels in adult homozygous mice
• this phenotype is not enhanced or suppressed by presence of Trp53tm1Sia mutation as compared to Ppp1r13btm1Suda homozygous mice





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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory