Puf60^tm1.1Kmtsu
Targeted Allele Detail

Summary

• Symbol: Puf60^tm1.1Kmtsu
• Name: poly-U binding splicing factor 60; targeted mutation 1.1, Kazuyuki Matsushita
• MGI ID: MGI:7487995
• Gene: Puf60 Location: Chr15:75942031-75952773 bp, - strand Genetic Position: Chr15, 35.32 cM, cytoband E1
• Alliance: Puf60^tm1.1Kmtsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233347
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP upstream of exon 3 and a neomycin resistance cassette with a 3' loxP downstream of exon 4. Cre-mediated recombination removed exons 3 and 4 along with the selection cassette. (J:233347)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Puf60 Mutation: 30 strains or lines available

References

• Original: J:233347 Matsushita K, et al., Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget. 2015 Mar 10;6(7):5102-17
• All: 1 reference(s)