Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2tm1Mddw mutation
(1 available);
any
Rac2 mutation
(17 available)
|
|
|
immune system
|
|
• mutant bone marrow neutrophils show a significant decrease in PMA-elicited NADPH oxidase activity relative to wild-type controls; however, the overall kinetics of PMA-induced superoxide production are normal
• mutant bone marrow neutrophils show a significant decrease in fMLP-elicited NADPH oxidase activity relative to wild-type controls; both a delay in reaching maximal enzyme activity and an overall decrease in superoxide production are observed
|
hematopoietic system
|
|
• mutant bone marrow neutrophils show a significant decrease in PMA-elicited NADPH oxidase activity relative to wild-type controls; however, the overall kinetics of PMA-induced superoxide production are normal
• mutant bone marrow neutrophils show a significant decrease in fMLP-elicited NADPH oxidase activity relative to wild-type controls; both a delay in reaching maximal enzyme activity and an overall decrease in superoxide production are observed
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2tm1Mddw mutation
(1 available);
any
Rac2 mutation
(17 available)
|
|
|
homeostasis/metabolism
cellular
|
|
• proliferation of vascular endothelial cells at a wound site is decreased compared to in wild-type mice
|
cardiovascular system
|
|
• proliferation of vascular endothelial cells at a wound site is decreased compared to in wild-type mice
|
|
|
• proliferation of vascular endothelial cells at a wound site is decreased compared to in wild-type mice
|
immune system
|
|
• respiratory burst activity of neutrophils at a wound site is decreased compared to in wild-type mice
|
hematopoietic system
|
|
• respiratory burst activity of neutrophils at a wound site is decreased compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2tm1Mddw mutation
(1 available);
any
Rac2 mutation
(17 available)
|
|
|
mortality/aging
|
|
• Aspergillus fumigatus-infected mice exhibit increased mortality and decreased survival time compared to similarly treated wild-type mice
|
immune system
|
|
• mice exhibit a modest excess of mature granulopoiesis in the bone marrow compared to in wild-type mice
|
|
|
• following anti-CD3 antibody stimulation, T cell proliferation is decreased compared to similarly treated wild-type cells
• CD4+ T cell proliferation in response to anti-CD3 antibodies is decreased 2-fold compared to similarly treated wild-type cells
• however, co-stimulation with anti-CD28 antibodies or the addition of IL2 can partially compensate for reduced proliferation of T cells
|
|
|
• at 4 post-thioglycollate treatment, peritoneal exudates exhibit reduced leukocyte numbers compared to in wild-type mice
|
|
|
• at 4 and 18 hours post-thioglycollate treatment, peritoneal exudates exhibit reduced neutrophils numbers compared to in wild-type mice
|
|
|
• 1.9-fold higher than in wild-type mice
|
|
|
• mice exhibit a 2.5- to 3-fold increased in neutrophil numbers compared to in wild-type mice
|
|
|
• PMA and NADPH-stimulated bone marrow neutrophils exhibit 23% of normal superoxide production
• however, peritoneal exudate neutrophils exhibit normal superoxide production following thioglycollate stimulation
• TNF-alpha and PMA-stimulated bone marrow neutrophils exhibit a 61% of normal superoxide production
• neutrophil integrin adhesion is decreased compared to wild-type cells
• chemotaxis of bone marrow neutrophils is decreased 4- to 10-fold compared to wild-type cells
|
|
|
• spreading of neutrophils over glass cover slips is 76% of that observed in wild-type cells
|
|
|
• Aspergillus fumigatus-infected mice exhibit increased mortality and decreased survival time compared to similarly treated wild-type mice
• 4 to 6 days post-infection with A. fumigatus, recovery of viable A. fumigatus in the brain and kidney is increased 9.2 and 5.5 times compared to in similarly treated wild-type mice
• foci of hyphae in the renal parenchyma of A. fumigatus-infected mice are surrounded by an exuberant neutrophil infiltrate unlike in wild-type mice
|
hematopoietic system
|
|
• mice exhibit a modest excess of mature granulopoiesis in the bone marrow compared to in wild-type mice
|
|
|
• following anti-CD3 antibody stimulation, T cell proliferation is decreased compared to similarly treated wild-type cells
• CD4+ T cell proliferation in response to anti-CD3 antibodies is decreased 2-fold compared to similarly treated wild-type cells
• however, co-stimulation with anti-CD28 antibodies or the addition of IL2 can partially compensate for reduced proliferation of T cells
|
|
|
• at 4 post-thioglycollate treatment, peritoneal exudates exhibit reduced leukocyte numbers compared to in wild-type mice
|
|
|
• at 4 and 18 hours post-thioglycollate treatment, peritoneal exudates exhibit reduced neutrophils numbers compared to in wild-type mice
|
|
|
• 1.9-fold higher than in wild-type mice
|
|
|
• mice exhibit a 2.5- to 3-fold increased in neutrophil numbers compared to in wild-type mice
|
|
|
• PMA and NADPH-stimulated bone marrow neutrophils exhibit 23% of normal superoxide production
• however, peritoneal exudate neutrophils exhibit normal superoxide production following thioglycollate stimulation
• TNF-alpha and PMA-stimulated bone marrow neutrophils exhibit a 61% of normal superoxide production
• neutrophil integrin adhesion is decreased compared to wild-type cells
• chemotaxis of bone marrow neutrophils is decreased 4- to 10-fold compared to wild-type cells
|
|
|
• spreading of neutrophils over glass cover slips is 76% of that observed in wild-type cells
|
cellular
|
|
• mice exhibit a modest excess of mature granulopoiesis in the bone marrow compared to in wild-type mice
|
|
|
• spreading of neutrophils over glass cover slips is 76% of that observed in wild-type cells
|
|
|
• following anti-CD3 antibody stimulation, T cell proliferation is decreased compared to similarly treated wild-type cells
• CD4+ T cell proliferation in response to anti-CD3 antibodies is decreased 2-fold compared to similarly treated wild-type cells
• however, co-stimulation with anti-CD28 antibodies or the addition of IL2 can partially compensate for reduced proliferation of T cells
|
hematopoietic system
|
|
• development blocked at the T1 stage
|
|
|
• diminished splenic T1 and T2 cells
|
|
|
• peritoneal B cells (B1) also reduced
|
|
|
• diminished recirculating follicular B cells
|
|
|
• splenic marginal B cells were reduced
|
immune system
|
|
• development blocked at the T1 stage
|
|
|
• diminished splenic T1 and T2 cells
|
|
|
• peritoneal B cells (B1) also reduced
|
|
|
• diminished recirculating follicular B cells
|
|
|
• splenic marginal B cells were reduced
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2tm1Mddw mutation
(1 available);
any
Rac2 mutation
(17 available)
Tg(TcrAND)53Hed mutation
(2 available)
|
|
|
immune system
|
|
• following TCR stimulation, calcium mobilization in CD4+ T cells is decreased compared to in similarly treated wild-type cells
|
|
|
• T cell proliferation is 2- to 3-fold lower following stimulation with I-EK+ or fibroblast APC expressing with I-EK+ and B7 molecules compared to in similarly treated wild-type cells
|
|
|
• following stimulation with TCR-specific antigen
|
homeostasis/metabolism
hematopoietic system
|
|
• following TCR stimulation, calcium mobilization in CD4+ T cells is decreased compared to in similarly treated wild-type cells
|
|
|
• T cell proliferation is 2- to 3-fold lower following stimulation with I-EK+ or fibroblast APC expressing with I-EK+ and B7 molecules compared to in similarly treated wild-type cells
|
cellular
|
|
• T cell proliferation is 2- to 3-fold lower following stimulation with I-EK+ or fibroblast APC expressing with I-EK+ and B7 molecules compared to in similarly treated wild-type cells
|
Analysis Tools