Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
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adipose tissue
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• increased brown adipose tissue depot weight
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cellular
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• mitochondria exhibit an impaired response to free fatty acid-induced decoupling to a de-energized state; linoleic acid, lauric acid and stearic acid stimulation of mitochondria showed reduced rates of de-energization compared to controls as measured by protonmotive force and oxygen consumption
• comparable content of mitochondrial protein
• decreased cytochrome c oxidase activity
• increased mitochondrial glycerol-3-phosphate dehydrogenase activity
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homeostasis/metabolism
Allelic Composition |
Ucp1tm1Kz/Ucp1tm1Kz
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Genetic Background |
(129S1.Cg-Ucptm1Kz x B6.Cg-Ucptm1Kz)F1 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
|
|
|
cellular
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• mitochondria exhibit an impaired response to free fatty acid-induced decoupling to a de-energized state; linoleic acid, lauric acid and stearic acid stimulation of mitochondria showed reduced rates of de-energization compared to controls as measured by protonmotive force and oxygen consumption
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
|
|
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adipose tissue
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• an increase in the number of brown adipocytes in the inguinal fat pad was observed at at 20oC on a high-fat diet
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• reduced weight of all white fat depots after a high-fat diet and exposure to 20oC temperatures for 8 weeks
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cellular
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• mitochondria exhibit an impaired response to free fatty acid-induced decoupling to a de-energized state; linoleic acid, lauric acid and stearic acid stimulation of mitochondria showed reduced rates of de-energization compared to controls as measured by protonmotive force and oxygen consumption
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growth/size/body
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• temperature dependent; at 20oC, animals did not gain weight as quickly as controls on a high-fat, high-sucrose diet, but at 27oC, the differences in body weight between mutants and controls were indistiguishable
• both groups of animals consumed similar amounts of food, indicating that the differences in body weight was not due to differences in energy intake
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• at 20oC on a high-fat diet
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
|
|
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adipose tissue
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• mass of brown fat was greater in homozygous mice than in controls; thought to be due to increased deposition of triglyceride
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homeostasis/metabolism
growth/size/body
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• animals did not become obese on either a low-fat or a high-fat diet
• no changes were observed in the body mass, selected fat-pad mass or in total body triglyceride content
• normal food intake was observed
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
|
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cellular
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• mutant mitochondria have lost the high GDP-binding capacity and do not become energized in reposnse to it; instead, mutant mitochondria are in a perpetually energized state
• mitochondria do respond to free fatty acids by uncoupling to a de-energized state similar to controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
Ucp3tm1Rei mutation
(0 available);
any
Ucp3 mutation
(4 available)
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growth/size/body
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• body weight and lean mass decline as the ambient temperature drops to 12C
• fat mass is maintained
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slntm1Peri mutation
(0 available);
any
Sln mutation
(11 available)
Ucp1tm1Kz mutation
(2 available);
any
Ucp1 mutation
(46 available)
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mortality/aging
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• fewer than expected mice are born
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