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Allele Symbol Allele Name Allele ID |
Wt1tm1Jae targeted mutation 1, Rudolf Jaenisch MGI:1857268 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• complete lack of the posthepatic mesenchymal plate
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• in some cases, persistent thoracic nephric ridges are seen in E12.5 and E13.5 embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous offspring from intercrosses of heterozygous F1 mice survive to birth, but die immediately after due to impaired lung inflation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous offspring from intercrosses of heterozygous F1 mice survive to birth, but die immediately after due to impaired lung inflation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• death between E13 and E15; no homozygous embryos are recovered after E15.5
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| N |
• normal aortic, pulmonary, mitral, and tricuspid valves
• normal atrial and ventricular septa
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• rounded apex
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• small amount of pericardial blood observed in some mice
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• degeneration of the metaneprhic blastema observed at E12
• apoptosis in 10 to 50% of the cells of the metanephric blastema
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• retarded development of the gonadal ridge followed by arrest around E14
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• small amount of pericardial blood observed in some mice
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• incomplete development resulting in the herniation of lung tissue into the abdominal cavity
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• arrested development
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• degeneration of the metaneprhic blastema observed at E12
• apoptosis in 10 to 50% of the cells of the metanephric blastema
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• impeded growth, putatively due to incomplete pleura expansion
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• degeneration of the metaneprhic blastema observed at E12
• apoptosis in 10 to 50% of the cells of the metanephric blastema
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• approximately 16% of homozygous offsrping from intercrosses of heterozygous F1 mice survive to birth, but died immediately after due to impaired lung inflation
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• some embryos die in utero
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• abnormal primordial diaphragm with the caudal and more anterior aspect unilaterally missing
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• left-sided posterolateral defects
• however, some mice had no diaphragmatic hernias
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• observed at E18.5 in mice on a background involving MF1
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• increased apoptosis of primordial spleen cells
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• spleen primordium is smaller at E13.5 and the connection to the prospective pancreas is shortened
• at E15.5, only some thickening of the mesogastrium is observed and not a well-developed spleen as in wild-type
• stromal cells fo the spleen fail to develop
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• almost complete absence of the spleen, correlated with increased apoptosis of primordial spleen cells
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• increased apoptosis of primordial spleen cells
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• spleen primordium is smaller at E13.5 and the connection to the prospective pancreas is shortened
• at E15.5, only some thickening of the mesogastrium is observed and not a well-developed spleen as in wild-type
• stromal cells fo the spleen fail to develop
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• almost complete absence of the spleen, correlated with increased apoptosis of primordial spleen cells
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• increased apoptosis of primordial spleen cells
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital diaphragmatic hernia | DOID:3827 |
OMIM:142340 OMIM:222400 OMIM:610187 |
J:114565 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• partial unilateral absence of pleuropericardial membranes in the hilus region resulting in pleural and pericardial cavities that are not separated at E14.5
• pleuropericardial membrane development is disturbed in embryos such that sinuatrial mesenchymal ridges form but they fail to fuse with the lining of the dorsal body wall or the mesothelial lining of the lung hilus
• pericardioperitoneal canals are not closed at E14.5
• slight, but significant, increase in proliferation is seen in the sinuatrial ridges at E12.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the formation of the epicardium is severely compromised in E12.5 embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in addition to reduced testes size, remainder of reproductive tract is hypoplastic
• histological analysis of proximal portion of male reproductive tract shows structures with coiled morphology and folded epithelium structure of oviduct
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• at E13.5, male testicular development, including Sertoli cell location and numbers appears normal, but from E15.5 to P7, development is abnormal
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• testes completely lack normal tubular architecture of controls and consist primarily of sheets of eosinophilic cells
• at E15.5, only a few tubule-like structures are observed
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• testes contain sheets of eosinophilic cells identified histologically as Leydig cells; these cells are observed in dense clusters interspersed with regions of fibroblast-like cells
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• in 7 week old males, testes size is ~10% of control wild-type littermates
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• males have a uterus in addition to vas deferens, epididymis, and seminal vesicles
• histological analysis of proximal portion of male reproductive tract shows structures with coiled morphology and folded epithelium structure of oviduct
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• based on aberrant structure of male testes, males are predicted to be sterile
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• at E13.5, male testicular development, including Sertoli cell location and numbers appears normal, but from E15.5 to P7, development is abnormal
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• testes completely lack normal tubular architecture of controls and consist primarily of sheets of eosinophilic cells
• at E15.5, only a few tubule-like structures are observed
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• testes contain sheets of eosinophilic cells identified histologically as Leydig cells; these cells are observed in dense clusters interspersed with regions of fibroblast-like cells
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• in 7 week old males, testes size is ~10% of control wild-type littermates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are observed at E16
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• 49% fewer than expected mice survive beyond weaning compared
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• at E16, whole kidney apoptosis is increased compared to in wild-type mice
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• the volume of collecting ducts is reduced compared to in wild-type mice
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• compared to in Pax21Neu heterozygotes and wild-type mice
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• at E16 and E19, mice exhibit abnormal kidney development that is more severe than in Pax21Neu heterozygotes
• however, kidney development at E13 is normal
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• renal calyces are reduced in size and number compared to in wild-type mice
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• the left kidney is 48% smaller than normal while the right kidney is 58% smaller than normal
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• kidneys contain fewer than normal nephrons with fewer mesenchymal condensates, comma-shaped bodies, and S-shaped bodies and looser mesenchyme adjacent to ureteric bud structures compared to in wild-type kidneys
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• in 20% of mice
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• at E16, whole kidney apoptosis is increased compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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