Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
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cardiovascular system
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• at E8.5, dorsal aorta is absent
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• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent
• at E9.5 no blood vessels are seen
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embryo
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• at E7.5 the extraembryonic mesoderm consists of only a single cell layer
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hematopoietic system
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• the number of hematopoietic progenitors and the number of erythoid, granulocyte/macrophage and mixed colonies formed are severely reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
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mortality/aging
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• no embryos are recovered at E10.5 but are present at E9.5
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embryo
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• at E8.5, yolk sac lack blood vessels and consist of a single layer of mesothelium lining the yolk sac endothelium
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• embryos exhibit necrosis likely from cardiac failure
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• allantois explants fail to form any endothelial structures
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cardiovascular system
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• at E8.5, yolk sac lack blood vessels and consist of a single layer of mesothelium lining the yolk sac endothelium
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• embryos exhibit necrosis likely from cardiac failure
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hematopoietic system
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• expression of markers for hematopiesis could not be detected at E8.5
• at E8.5 only very rare committed hematopoietic cells could be identified by methylcellulose colony assay
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growth/size/body
cellular
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• embryos exhibit necrosis likely from cardiac failure
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
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cardiovascular system
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• Kdr+ cells (lacZ expressing) reach the anterior portion portion of the embryo but no blood vessels develop
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Allelic
Composition |
Kdrtm1Jrt/Kdr+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
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Allelic
Composition |
Kdrtm1Jrt/Kdrtm1.1Msh
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Genetic
Background |
involves: 129P2/OlaHsd * B6.129-Kdrtm1Jrt/J * C57BL/6J |
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cardiovascular system
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• at E8.5, dorsal aorta is absent
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• at E8.5 vessels in the head as well as the dorsal aorta and vitelline artery are absent
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embryo
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• at E7.5 the extraembryonic mesoderm consists of only a single cell layer
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Defect in angioblast differentiation in Ptentm1Hwu/Ptentm1Hwu Kdrtm1Jrt/Kdr+ Twist2tm1.1(cre)Dor/Twist2+ mice
cardiovascular system
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• vasculogenesis defect
• impaired differentiation of angioblasts into mature endothelial cells and blood vessels
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respiratory system
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• increase in angioblasts in E18.5 lungs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm1.1Fong mutation
(1 available);
any
Flt1 mutation
(73 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
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cardiovascular system
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• in the brain and liver of tamoxifen treated mice compared with control mice but not as severe as in mice also lacking the Kdr null allele
• some small focal areas in the retina in tamoxifen-treated mice relative to mice lacking the Kdr null allele
• however, angiogenesis in the heart is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
Kdrtm2Sato mutation
(1 available);
any
Kdr mutation
(71 available)
Tg(Nes-cre)1Wmz mutation
(0 available)
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nervous system
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N |
• normal numbers of gonadotropin-releasing hormone neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1.1Jamb mutation
(0 available);
any
Kdr mutation
(71 available)
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
Tg(CAG-cre/Esr1*)1Egwa mutation
(0 available)
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Suppression of of extraretinal vascular outgrowth in ischemic Kdrtm1.1Jamb/Kdrtm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas
cardiovascular system
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• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice
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vision/eye
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• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
Prdm1tm2Rob mutation
(0 available);
any
Prdm1 mutation
(64 available)
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embryo
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• fetal capillaries fail to extend into the labyrinth tissue and instead are largely restricted to the base of the labyrinth
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cardiovascular system
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• fetal capillaries fail to extend into the labyrinth tissue and instead are largely restricted to the base of the labyrinth
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
Tmem204tm1.1Ali mutation
(0 available);
any
Tmem204 mutation
(14 available)
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immune system
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• abnormal smooth muscle cell coating
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• enlarged lymphatic vessels are even more dilated than in Tmem204tm1.1Ali single knock-outs
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muscle
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• abnormal smooth muscle cell coating
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation
(1 available);
any
Kdr mutation
(71 available)
Rasip1tm1.1Oncl mutation
(0 available);
any
Rasip1 mutation
(31 available)
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cardiovascular system
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• at E9.5, mice fail to exhibit remodeling of the initial plexus in embryonic tissue unlike wild-type mice
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embryo
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• at E9.5, mice fail to exhibit remodeling of the initial plexus in the yolk sac unlike wild-type mice
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liver/biliary system
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• at E12.5, liver vasculature is less organized and vessels are dilated
• at E13.5, microvascular network is more disorganized with fewer branches than in control livers; newborns have very little microvascular network is observed
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mortality/aging
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• all of the double homozygotes die as embryos
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cardiovascular system
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo
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cellular
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo
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mortality/aging
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• about 90% of mutants die as embryos
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cardiovascular system
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• differentiation of vascular endothelial cells is disturbed
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo
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cellular
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• differentiation of vascular endothelial cells is disturbed
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo
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Analysis Tools