Tg(tetO-Kdr*)4377.5Rwng
Transgene Detail

Summary

• Symbol: Tg(tetO-Kdr*)4377.5Rwng
• Name: transgene insertion 4377.5, Rong Wang
• MGI ID: MGI:3810550
• Synonyms: TRE-VEGFR2T
• Transgene: Tg(tetO-Kdr*)4377.5Rwng Location: unknown
• Alliance: Tg(tetO-Kdr*)4377.5Rwng page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Kdr*)4377.5Rwng expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kdr (MGI:96683)

• Mutation details: The transgene construct was designed with a truncated mouse Kdr (kinase insert domain protein receptor) gene, under the control of heptamerized tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequences and a cytomegalovirus minimal promoter with a beta-globin poly A signal. The truncated gene encodes amino acids 1 through 828, which includes the cytoplasmic tyrosine kinase domain, and has a hemaglutin (HA) tag fused at the C terminus.This transgene was injected into fertilized FVB/N mouse eggs. Founder line 4377.5 was subsequently established. (J:100427)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:100427 Carpenter B, et al., VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development. 2005 Jul;132(14):3293-303
• All: 1 reference(s)