Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
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nervous system
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• the number of cells in the dorsal lateral geniculate nucleus is decreased compared to in wild-type mice
• however, the size of the neuronal somata is normal
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• the number of cells in the medial nucleus of the amygdala is decreased compared to in wild-type mice
• however, the size of the neuronal somata is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
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cardiovascular system
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• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• PE-treated mice exhibit a positive chronotropic response compared with similarly treated wild-type mice
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• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
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cardiovascular system
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• loss of pressure responses to angiotensin II administration
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• arterial pressure measured by carotid cannula is reduced by 43 mmHg, however homozygotes appear to have a normal heart, kidney and vascular system
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• systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 24 mmHg
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Allelic
Composition |
Agtr1atm1Unc/Agtr1a+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
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cardiovascular system
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• pressure responses to angiotensin II administration are short lived compared to wild-type
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• arterial pressure measured by carotid cannula is reduced by 17 mmHg
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• systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 12 mmHg
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Efemp2tm1.1Hiya mutation
(0 available);
any
Efemp2 mutation
(26 available)
Efemp2tm1.2Hiya mutation
(0 available);
any
Efemp2 mutation
(26 available)
Tg(Tagln-cre)1Her mutation
(2 available)
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cardiovascular system
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• aortic wall is thicker at 3 months of age compared to single Agtr1a homozygotes
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cardiovascular system
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• angiotensin II-treated mice fed a high-fat diet do not exhibit ascending aortic aneurysms unlike similarly treated Ldlrtm1Her homozygotes
• bone marrow transplant do not alter incidence of angiotensin II-induced ascending aortic aneurysms compared with similarly treated Ldlrtm1Her homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation
(0 available);
any
Hprt1 mutation
(1274 available)
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cardiovascular system
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• hypotension develops on low salt diet and blood pressure fails to rise on a high salt diet
• fails to correct blood pressure defect caused by homozygous Agtr1tm1Unc
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homeostasis/metabolism
renal/urinary system
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• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Agtr1btm1Cof mutation
(0 available);
any
Agtr1b mutation
(18 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation
(0 available);
any
Hprt1 mutation
(1274 available)
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homeostasis/metabolism
renal/urinary system
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• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved
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growth/size/body
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• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Agtr1btm1Cof mutation
(0 available);
any
Agtr1b mutation
(18 available)
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mortality/aging
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• fewer than expected mice are present at weaning
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cardiovascular system
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• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
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homeostasis/metabolism
renal/urinary system
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• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
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• mice exhibit cystic dilated cavities unlike wild-type mice
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• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice
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• severely dilated Bowman's space
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• multifocal and focally extensive glomeruli atrophy
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• partially dilated tubular lumina unlike in wild-type mice
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growth/size/body
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• mice exhibit cystic dilated cavities unlike wild-type mice
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immune system
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• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Agtr2tm1Tin mutation
(0 available);
any
Agtr2 mutation
(11 available)
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cardiovascular system
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• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
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• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
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homeostasis/metabolism
renal/urinary system
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• mice exhibit cystic dilated Bowman's space unlike wild-type mice
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• mice exhibit multifocal glomeruli atrophy unlike wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Agtr2tm1Tin mutation
(0 available);
any
Agtr2 mutation
(11 available)
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cardiovascular system
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• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
|
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• Ang II-treated mice exhibit less of an increase in mean arterial blood pressure and heart rate compared with similarly treated wild-type mice
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homeostasis/metabolism
renal/urinary system
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• mice exhibit cystic dilated Bowman's space unlike wild-type mice
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• mice exhibit multifocal glomeruli atrophy unlike wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Agtr1btm1Cof mutation
(0 available);
any
Agtr1b mutation
(18 available)
Agtr2tm1Tin mutation
(0 available);
any
Agtr2 mutation
(11 available)
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mortality/aging
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• fewer than expected mice are present at weaning
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cardiovascular system
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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homeostasis/metabolism
renal/urinary system
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• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes
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growth/size/body
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• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation
(1 available);
any
Agtr1a mutation
(40 available)
Agtr1btm1Cof mutation
(0 available);
any
Agtr1b mutation
(18 available)
Agtr2tm1Tin mutation
(0 available);
any
Agtr2 mutation
(11 available)
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mortality/aging
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• fewer than expected mice are present at weaning
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cardiovascular system
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with a shortened time to peak MAP and an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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homeostasis/metabolism
renal/urinary system
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• compared with wild type mice and Agtr1atm1Unc Agtr1btm1Cof double homozygotes
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growth/size/body
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• compared with wild-type mice that is not as severe as in Agtr1atm1Unc Agtr1btm1Cof double homozygotes
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Analysis Tools