All Phenotypes Hr<hr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hr^hr
hairless
MGI:1856057

Summary

25 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hr^hr/Hr^hr	HRS/J	MGI:3698738
hm2	Hr^hr/Hr^hr	Not Specified	MGI:2669529
ht3	Hr^hr/Hr^rh-2J	involves: BALB/cBy * C57BL/6By * HRS/J	MGI:5307224
ht4	Hr^hr/Hr^hr-3J	involves: MRL/MpJ	MGI:5316838
ht5	Hr^N/Hr^hr	involves: ORNL:STOCK A^w/a Oca2^p	MGI:4414846
cn6	Ercc1^tm1Dwm/Ercc1^tm2Dwm Hr^hr/Hr^hr Tg(KRT5-cre)5132Jlj/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1	MGI:3696991
cx7	Adam10^Pied/Adam10⁺ Hr^hr/Hr⁺	HRA/SkhKcl-Adam10^Pied Hr^Hr	MGI:6163712
cx8	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr	HRA/SkhKcl-Adam10^Pied Hr^Hr	MGI:6163711
cx9	Hr^hr/Hr^hr Msh2^tm1Htr/Msh2^tm1Htr	involves: 129P2/OlaHsd	MGI:4429630
cx10	Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh	MGI:6163722
cx11	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl	MGI:6163720
cx12	Hr^hr/Hr^hr Msh2^tm1Htr/Msh2^tm1Htr Xpa^tm1Tnka/Xpa^tm1Tnka	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4429631
cx13	Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2^tm1Unc	involves: 129P2/OlaHsd * C57BL/6 * SKH1	MGI:4366347
cx14	Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6 * SKH1	MGI:4366348
cx15	Hr^hr/Hr^hr Ptgs1^tm1Unc/Ptgs1⁺	involves: 129P2/OlaHsd * C57BL/6 * SKH1	MGI:4366349
cx16	Adam10^Pied/Adam10⁺ Cd44^tm1Hbg/Cd44^tm1Hbg Hr^hr/Hr^hr	involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl	MGI:6163716
cx17	Hr^hr/Hr^hr Ptger2^tm1Brey/Ptger2^tm1Brey	involves: 129S6/SvEvTac * C57BL/6 * SKH1	MGI:4834867
cx18	Hr^hr/Hr^hr Ptger2^tm1Brey/Ptger2⁺	involves: 129S6/SvEvTac * C57BL/6 * SKH1	MGI:4834868
cx19	Hr^hr/Hr^hr Tg(KRT14-Birc5)19Gros/0	involves: C3H * C57BL/6 * SKH1	MGI:3794731
cx20	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(Dct-lacZ)A12Jkn/0	involves: C3HeB/FeJ * C57BL/6 * CBA * HRA/SkhKcl	MGI:6163724
cx21	Hr^hr/Hr^hr Tg(CD2-Stat6V625AT626A)78Mhk/0	involves: C3H * SKH1	MGI:5762832
cx22	Hr^hr/Hr^hr Xpa^tm1Tnka/Xpa^tm1Tnka	involves: C57BL/6 * CBA	MGI:4429632
cx23	Hr^hr/Hr^hr Tg(KRT14-Ptgs2)1Sumf/0	involves: C57BL/6 * DBA/2 * FVB/N * SKH1	MGI:4366350
cx24	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(KRT14-Kitl*)4XTG2Bjl/0	involves: C57BL/6J * HRA/SkhKcl * SJL	MGI:6163714
cx25	Adam10^Pied/Adam10^Pied Hr^hr/Hr^hr	involves: CAST/EiJ * HRA/SkhKcl	MGI:6163718

Allelic Composition	Hr^hr/Hr^hr
Genetic Background	HRS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hr^hr/Hr^hr mouse

hearing/vestibular/ear

absent linear vestibular evoked potential ( J:116914 )

• VESPs are absent at the maximum stimulus intensity used

neoplasm

increased leukemia incidence ( J:5726 , J:5908 , J:24786 )

• increased incidence (J:5726)

• increased incidence (J:5908)

• at 8 to 10 months of age 45% of homozygotes have lymphoid leukemia, compared with only 1% in heterozygotes, and approximately 72% of these homozygotes develop myeloid leukemia later in life up to 18 months of age (J:24786)

hematopoietic system

decreased T cell proliferation ( J:6375 )

• to alloantigens by T helper cells

decreased T cell number ( J:6087 )

• of CD5+ T cells

increased macrophage cell number ( J:150402 )

• although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes

immune system

decreased T cell proliferation ( J:6375 )

• to alloantigens by T helper cells

decreased T cell number ( J:6087 )

• of CD5+ T cells

increased macrophage cell number ( J:150402 )

cellular

decreased T cell proliferation ( J:6375 )

• to alloantigens by T helper cells

Allelic Composition	Hr^hr/Hr^hr
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:2409 )

• small

• nipple at bottom of cup-shaped depression in skin

• no ducts

sebaceous gland atrophy ( J:2409 )

behavior/neurological

abnormal nursing ( J:2409 )

• failure

integument

abnormal mammary gland morphology ( J:2409 )

• small

• nipple at bottom of cup-shaped depression in skin

• no ducts

sebaceous gland atrophy ( J:2409 )

hairless ( J:2405 , J:2409 )

• beginning ~15 days of age and progressing from nose back (J:2405)

deformed nails ( J:2409 )

• curved

abnormal skin morphology ( J:2409 )

• thickened cutis

dermal cyst ( J:2409 , J:14889 )

abnormal dermis reticular layer morphology ( J:2409 )

• cystic

hyperkeratosis ( J:14940 )

epidermal hyperplasia ( J:14940 )

growth/size/body

dermal cyst ( J:2409 , J:14889 )

Allelic Composition	Hr^hr/Hr^rh-2J
Genetic Background	involves: BALB/cBy * C57BL/6By * HRS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Hr^rh-2J mutation (0 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

wrinkled skin ( J:27523 )

• distinctive wrinkling of the skin compared with homozygous Hr^hr mutant mice

Allelic Composition	Hr^hr/Hr^hr-3J
Genetic Background	involves: MRL/MpJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Hr^hr-3J mutation (0 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:78381 )

• around 2 weeks of age the first coat is lost from the nose to the back of the mouse and does not regrow

hairless ( J:78381 )

Allelic Composition	Hr^N/Hr^hr
Genetic Background	involves: ORNL:STOCK A^w/a Oca2^p

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Hr^N mutation (2 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat appearance ( J:7103 )

• this genotype looks like heterozygous, Hr/+, mice

abnormal skin condition ( J:7103 )

• this genotype looks like heterozygous Hr/+ mice

Allelic Composition	Ercc1^tm1Dwm/Ercc1^tm2Dwm Hr^hr/Hr^hr Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc1^tm1Dwm mutation (0 available); any Ercc1 mutation (27 available)
Ercc1^tm2Dwm mutation (0 available); any Ercc1 mutation (27 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:115849 )

• mice with a maternally inherited cre transgene die before weaning

• however, mice with a paternally inherited cre transgene are viable

neoplasm

increased incidence of tumors by UV-induction ( J:115849 )

• mice with a paternally inherited cre transgene develop tumors following chronic exposure to 125 J/m² UVB unlike control mice

• tumors appear earlier and grow faster in mice with a paternally inherited cre transgene compared to control mice receiving a 16-fold higher dose of UVB

• the cumulative UVB EC50 for tumor development is 3.75 kJ/m² in mice with a paternally inherited cre transgene compared to 140 kJ/m²control mice

growth/size/body

decreased birth body size ( J:115849 )

• mice with a maternally inherited cre transgene are severely runted at birth

liver/biliary system

abnormal hepatocyte morphology ( J:115849 )

• mice with a maternally inherited cre transgene develop premature polyploidy in hepatocytes

integument

increased sensitivity to skin irradiation ( J:115849 )

• the minimal erythemal dose of UVB is 40 J/m² in mice with a paternally inherited cre transgene compared to 900 J/m² in controls

• in mice with a paternally inherited cre transgene sensitivity to UVB induced changes in the epidermis (hyperplasia, hypertrophy, hypergranulosis, and hyperkeratosis) are increased

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr⁺
Genetic Background	HRA/SkhKcl-Adam10^Pied Hr^Hr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:262499 )

N	• no macules are observed in trunk hair

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr
Genetic Background	HRA/SkhKcl-Adam10^Pied Hr^Hr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• unlike in Hr^Hr homozygotes, 20 week old mice exhibit light brown, freckle-like spots or macules with a striated appearance due to a heavier concentration of melanin at the dermis and epidermis junction

• at 10 months, mice exhibit un-striated macules in the tail, ear and feet that does not change skin color unlike in Hr^Hr homozygotes

pigmentation

abnormal skin pigmentation ( J:262499 )

• at 10 months, mice exhibit un-striated macules in the tail, ear and feet that does not change skin color unlike in Hr^Hr homozygotes

Allelic Composition	Hr^hr/Hr^hr Msh2^tm1Htr/Msh2^tm1Htr
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Msh2^tm1Htr mutation (1 available); any Msh2 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:79734 )

• 20% of mice die 15 weeks after UVB-irradiation unlike similarly treated wild-type mice

premature death ( J:79734 )

• 20% of mice die of lymphomas by 20 weeks of age

neoplasm

increased skin tumor incidence ( J:79734 )

• by 52 weeks, 81% of mice develop skin tumors

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

increased skin papilloma incidence ( J:79734 )

• 23% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 77% of spontaneous skin tumors are squamous cell carcinomas

increased lymphoma incidence ( J:79734 )

• 20% of mice die of lymphomas by 20 weeks of age

• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice

increased incidence of tumors by UV-induction ( J:79734 )

• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

• UVB-irradiated mice do not remain tumor free as long as similarly treated wild-type mice

integument

increased skin tumor incidence ( J:79734 )

• by 52 weeks, 81% of mice develop skin tumors

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

increased skin papilloma incidence ( J:79734 )

• 23% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 77% of spontaneous skin tumors are squamous cell carcinomas

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:79734 )

• 20% of mice die 15 weeks after UVB-irradiation unlike similarly treated wild-type mice

Allelic Composition	Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• light brown, freckle-like spots or macules with a striated appearance at 5 months of age

pigmentation

abnormal skin pigmentation ( J:262499 )

• light brown, freckle-like spots or macules with a striated appearance at 5 months of age

Allelic Composition	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small pharyngeal arch ( J:262499 )

• at E9.5

caudal body truncation ( J:262499 )

• at E9.5

decreased embryo size ( J:262499 )

• at E9.5

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

abnormal somite border morphology ( J:262499 )

• not delineated at E9.5

cardiovascular system

abnormal heart looping ( J:262499 )

• linear at E9.5

enlarged pericardium ( J:262499 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

telencephalon hypoplasia ( J:262499 )

• at E9.5

growth/size/body

decreased embryo size ( J:262499 )

• at E9.5

craniofacial

small pharyngeal arch ( J:262499 )

• at E9.5

Allelic Composition	Hr^hr/Hr^hr Msh2^tm1Htr/Msh2^tm1Htr Xpa^tm1Tnka/Xpa^tm1Tnka
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:79734 )

• 32% of mice die 15 weeks after UVB-irradiation compared with 3% of similarly treated Xpa^tm1Tnka homozygotes

premature death ( J:79734 )

• 18% of mice die of lymphomas by 20 weeks of age

neoplasm

increased skin tumor incidence ( J:79734 )

• in 81% of mice by 52 weeks

increased skin papilloma incidence ( J:79734 )

• 9% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 91% of skin tumors are squamous cell carcinomas

• all skin tumors in UVB-treated mice are diagnosed as squamous cell carcinomas

increased lymphoma incidence ( J:79734 )

• 18% of mice die of lymphomas by 20 weeks of age

increased incidence of tumors by UV-induction ( J:79734 )

• UVB-treated mice develop skin tumors a week earlier than similarly treated Xpa^tm1Tnka homozygotes

• all UVB-treated mice develop skin tumors, all of which are squamous cell carcinomas, at 10 weeks compared with 20 weeks for similarly treated Xpa^tm1Tnka homozygotes

integument

increased skin tumor incidence ( J:79734 )

• in 81% of mice by 52 weeks

increased skin papilloma incidence ( J:79734 )

• 9% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 91% of skin tumors are squamous cell carcinomas

• all skin tumors in UVB-treated mice are diagnosed as squamous cell carcinomas

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:79734 )

• 32% of mice die 15 weeks after UVB-irradiation compared with 3% of similarly treated Xpa^tm1Tnka homozygotes

Allelic Composition	Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:121635 )

• mice do not survive beyond several weeks of age

Allelic Composition	Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SKH1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by UV induction ( J:121635 )

• after 14 weeks of UV treatment, mice fail to develop tumors unlike similarly treated SKH mice and do not develop tumors until 24 weeks of treatment

• UV-treated mice exhibit a 65% reduction in tumor number and decreased tumor incidence compared with similarly treated wild-type mice

homeostasis/metabolism

decreased prostaglandin level ( J:121635 )

• 50% in the epidermis

cellular

increased cell proliferation ( J:121635 )

• skin from UV-treated mice exhibits 50% less basal cell proliferation than in skin from similarly treated wild-type mice

Allelic Composition	Hr^hr/Hr^hr Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:121635 )

N	• UV-exposed mice exhibit normal induction of tumors

homeostasis/metabolism

decreased prostaglandin level ( J:121635 )

• 50% in the epidermis

cellular

increased cell proliferation ( J:121635 )

• skin from UV-treated mice exhibits 20% less basal cell proliferation than in skin from similarly treated wild-type mice

Allelic Composition	Adam10^Pied/Adam10⁺ Cd44^tm1Hbg/Cd44^tm1Hbg Hr^hr/Hr^hr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Cd44^tm1Hbg mutation (4 available); any Cd44 mutation (67 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• trunk and tail macules at 10 months

pigmentation

abnormal skin pigmentation ( J:262499 )

• trunk and tail macules at 10 months

Allelic Composition	Hr^hr/Hr^hr Ptger2^tm1Brey/Ptger2^tm1Brey
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Ptger2^tm1Brey mutation (4 available); any Ptger2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:117581 )

• UVR induced tumors are more erythematous and have less keratinization

• UVR induced tumors are more likely to be poorly differentiated and deeply invasive compared to tumors in wild-type mice

increased tumor growth/size ( J:117581 )

• while the total number of tumors is reduced, the number of larger lesions (greater than 10 mm in diameter) is increased

decreased incidence of tumors by UV induction ( J:117581 )

• develop about half as many tumors as wild-type mice following a 15 week escalating light dose protocol

integument

abnormal skin physiology ( J:117581 )

• after a modest UVR exposure (180 mJ/cm²) keratinocyte proliferation is significantly lower compared to wild-type controls

• however, keratinocyte proliferation following higher levels of UVR exposure is similar to wild-type controls

Allelic Composition	Hr^hr/Hr^hr Ptger2^tm1Brey/Ptger2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SKH1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:117581 )

N	• unlike mice homozygous for both alleles, mice heterozygous for Ptger2^tm1Brey do not show any protection against tumor formation following a 15 week escalating light dose protocol

integument

abnormal skin physiology ( J:117581 )

• after a modest UVR exposure (180 mJ/cm²) keratinocyte proliferation is significantly lower compared to wild-type controls

• however, keratinocyte proliferation following higher levels of UVR exposure is similar to wild-type controls

Allelic Composition	Hr^hr/Hr^hr Tg(KRT14-Birc5)19Gros/0
Genetic Background	involves: C3H * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Tg(KRT14-Birc5)19Gros mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased squamous cell carcinoma incidence ( J:95011 )

• mice exhibit a doubling of the conversion rate of papillomas to squamous cell carcinomas compared to hairless mice

decreased incidence of tumors by UV induction ( J:95011 )

• following chronic exposure to UVB, tumor burden is reduced 1.5-fold compared to in hairless mice

integument

decreased sensitivity to skin irradiation ( J:95011 )

• mice are 2- to 5-fold more resistant to sunburn cell formation than hairless mice following exposure to UVB

• however, skin differentiation is normal

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(Dct-lacZ)A12Jkn/0
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * CBA * HRA/SkhKcl

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanocyte morphology ( J:262499 )

• groups of melanocytes are observed at 3 months unlike in Hr^Hr homozygotes

• at 5 months, mice exhibit large groups of melanocytes with melanin deposition in the epidermis unlike Hr^Hr homozygotes

increased melanocyte number ( J:262499 )

• in the skin

integument

hairless ( J:262499 )

Allelic Composition	Hr^hr/Hr^hr Tg(CD2-Stat6V625AT626A)78Mhk/0
Genetic Background	involves: C3H * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Tg(CD2-Stat6*V625A*T626A)78Mhk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

eye inflammation ( J:230018 )

• keratitis is seen in 35% of mice by 20 weeks of age

blepharitis ( J:230018 )

• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids

• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids

• treatment of eyelids with clobetasol reverses blepharitis

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

uveitis ( J:230018 )

• uveitis, with inflammatory exudates in the anterior chamber of the eye

abnormal cornea morphology ( J:230018 )

• corneal disease (neovascular pannus formation) is seen

• cornea exhibits keratinization of the epithelial layer, increased stromal inflammatory cells, neovascularization and corneal edema

• proteinous exudates with cellular infiltrates are seen along with erosion of the Descemente's membrane

abnormal eyelid morphology ( J:230018 )

• eyelid erythema evident as early as 7 weeks of age

• Th2 cytokine expression is increased in eyelids, indicating allergic inflammation

loss of eyelid cilia ( J:230018 )

• excoriations and madarosis evident as early as 7 weeks of age

immune system

eye inflammation ( J:230018 )

• keratitis is seen in 35% of mice by 20 weeks of age

blepharitis ( J:230018 )

• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids

• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids

• treatment of eyelids with clobetasol reverses blepharitis

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

uveitis ( J:230018 )

• uveitis, with inflammatory exudates in the anterior chamber of the eye

cardiovascular system

abnormal physiological neovascularization ( J:230018 )

• peripheral neovascularization of the cornea, which extends centrally

endocrine/exocrine glands

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

homeostasis/metabolism

edema ( J:230018 )

• periocular edema evident as early as 7 weeks of age

integument

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

loss of eyelid cilia ( J:230018 )

• excoriations and madarosis evident as early as 7 weeks of age

Allelic Composition	Hr^hr/Hr^hr Xpa^tm1Tnka/Xpa^tm1Tnka
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Xpa^tm1Tnka mutation (0 available); any Xpa mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin tumor incidence ( J:79734 )

• after 20 weeks, 100% of UVB-irradiated mice develop skin tumors

integument

increased skin tumor incidence ( J:79734 )

• after 20 weeks, 100% of UVB-irradiated mice develop skin tumors

Allelic Composition	Hr^hr/Hr^hr Tg(KRT14-Ptgs2)1Sumf/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Tg(KRT14-Ptgs2)1Sumf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by UV-induction ( J:121635 )

homeostasis/metabolism

increased prostaglandin level ( J:121635 )

• in the epidermis

cellular

decreased cell proliferation ( J:121635 )

• slightly in the skin of UV-exposed mice compared to skin from similarly treated wild-type mice

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(KRT14-Kitl*)4XTG2Bjl/0
Genetic Background	involves: C57BL/6J * HRA/SkhKcl * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• at 5 months, mice exhibit the same degree of light trunk pigmentation as in Tg(KRT14-Kitl*)4XTG2Bjl mice

pigmentation

abnormal skin pigmentation ( J:262499 )

• at 5 months, mice exhibit the same degree of light trunk pigmentation as in Tg(KRT14-Kitl*)4XTG2Bjl mice

Allelic Composition	Adam10^Pied/Adam10^Pied Hr^hr/Hr^hr
Genetic Background	involves: CAST/EiJ * HRA/SkhKcl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:262499 )

• no mice are present at weaning

embryo

small pharyngeal arch ( J:262499 )

• at E9.5

caudal body truncation ( J:262499 )

• at E9.5

decreased embryo size ( J:262499 )

• at E9.5

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

abnormal somite border morphology ( J:262499 )

• not delineated at E9.5

cardiovascular system

abnormal heart looping ( J:262499 )

• linear at E9.5

enlarged pericardium ( J:262499 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

telencephalon hypoplasia ( J:262499 )

• at E9.5

growth/size/body

decreased embryo size ( J:262499 )

• at E9.5

craniofacial

small pharyngeal arch ( J:262499 )

• at E9.5

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