Adgrf5^tm1.2Jpbs
Targeted Allele Detail

Summary

• Symbol: Adgrf5^tm1.2Jpbs
• Name: adhesion G protein-coupled receptor F5; targeted mutation 1.2, James P Bridges
• MGI ID: MGI:5697003
• Synonyms: GPR116^delta17
• Gene: Adgrf5 Location: Chr17:43671342-43770448 bp, + strand Genetic Position: Chr17, 19.73 cM
• Alliance: Adgrf5^tm1.2Jpbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221769
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 17. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 17. Flp-mediated recombination removed the selection cassette and left exon 17 floxed. Cre-mediated recombination removed exon 17. (J:221769)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrf5 Mutation: 73 strains or lines available

References

• Original: J:221769 Bridges JP, et al., Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57
• All: 4 reference(s)