Adgrf5 MGI Mouse Gene Detail - MGI:2182928 - adhesion G protein-coupled receptor F5

Symbol

Adgrf5
Name

adhesion G protein-coupled receptor F5
Synonyms

8430401C09Rik, Gpr116

Feature Type

protein coding gene
IDs

MGI:2182928
NCBI Gene: 224792
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr17:43671342-43770448 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.73 cM
Mapping Data

2 experiments

SNPs within 2kb

3335 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182928	protein coding gene	Chr17:43671225-43770448 (+)
129S1/SvImJ	ENSMUSG00200050001	protein coding gene	Chr17:38913085-38968794 (+)
A/J	ENSMUSG00195045723	protein coding gene	Chr17:40419346-40475031 (+)
AKR/J	ENSMUSG00220051197	protein coding gene	Chr17:39380330-39436037 (+)
BALB/cJ	ENSMUSG00180041951	protein coding gene	Chr17:40162607-40218277 (+)
C3H/HeJ	ENSMUSG00175039431	protein coding gene	Chr17:39462010-39517708 (+)
C57BL/6NJ	ENSMUSG00215052953	protein coding gene	Chr17:39018004-39073638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021628	protein coding gene	Chr17:40119371-40188026 (+)
CAST/EiJ	ENSTCUG00005050030	protein coding gene	Chr17:40216857-40271871 (+)
CBA/J	ENSMUSG00210037525	protein coding gene	Chr17:39211822-39267519 (+)
DBA/2J	ENSMUSG00185027127	protein coding gene	Chr17:42143417-42199088 (+)
FVB/NJ	ENSMUSG00205021292	protein coding gene	Chr17:39697633-39753299 (+)
JF1/MsJ	ENSUMUG00000020037	protein coding gene	Chr17:41759590-41815374 (+)
LP/J	ENSMUSG00230039988	protein coding gene	Chr17:43016123-43071827 (+)
NOD/ShiLtJ	ENSMUSG00190030773	protein coding gene	Chr17:39113189-39168864 (+)
NZO/HlLtJ	ENSMUSG00225043173	protein coding gene	Chr17:45286756-45342457 (+)
PWK/PhJ	ENSLUMG00010033801	protein coding gene	Chr17:38987926-39043906 (+)
SPRET/EiJ	ENSMSPG00010048923	protein coding gene	Chr17:39157194-39252399 (+)
WSB/EiJ	ENSIUOG00005048251	protein coding gene	Chr17:40078207-40134023 (+)

Human Ortholog

ADGRF5, adhesion G protein-coupled receptor F5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRF5, adhesion G protein-coupled receptor F5
Synonyms

GPR116, KPG_001
Links

HGNC:19030

NCBI Gene ID: 221395

UniProt: Q8IZF2
Chr Location

6p12.3; chr6:46852310-46956392 (-) GRCh38

MGI Vertebrate Homology

Adgrf5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRF5
Gene Tree

Adgrf5

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Phenotype Summary

39 phenotypes from 6 alleles in 9 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

1
Endonuclease-mediated

6
Targeted

15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit premature death, decreased body weight and respiratory distress associated with pulmonary alveolar proteinosis.

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All GO Annotations

32
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
Tissues

45
cDNA Data

62
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

76
RefSeq

26
UniProt

7
CCDS

CCDS37622.1

Ensembl

ENSMUSG00000056492 (Evidence)
NCBI Gene

224792

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056492	Ensembl Gene Model \| MGI Sequence Detail	99107	C57BL/6J	± kb
transcript	ENSMUST00000226087	Ensembl \| MGI Sequence Detail	4954	Not Applicable
polypeptide	ENSMUSP00000153049	Ensembl \| MGI Sequence Detail	1348	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000031659 adhesion G protein-coupled receptor F5

(term hierarchy)
InterPro Domains

IPR057400 ADGRF3/5-like, N-terminal domain

IPR051587 Adhesion G protein-coupled receptor F

IPR046338 GAIN domain superfamily

IPR057244 GAIN, subdomain B

IPR008078 GPCR family 2, Ig-hepta-like receptor

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

IPR000203 GPS motif

IPR003599 Immunoglobulin domain subtype

IPR013151 Immunoglobulin-like beta-sandwich domain

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR000082 SEA domain

IPR036364 SEA domain superfamily
GlyGen

G5E8Q8 15 sites, 7 N-linked glycans (10 sites)

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All nucleic 69

cDNA 62

Primer pair 6

Other 1

Antibodies 1

Microarray probesets 5

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MGI:1918736, MGI:2146888

Summaries

All 71

Developmental Gene Expression 10

Gene Ontology 14

Phenotypes 29
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:374077 Suhardi VJ, et al., Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor. Nat Biomed Eng. 2024 Oct;8(10):1285-1307

TSS for Adgrf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144671	Chr17:43670911-43670921 (+)	-426 bp
Tssr144672	Chr17:43671213-43671227 (+)	-122 bp
Tssr144673	Chr17:43671254-43671273 (+)	-78 bp
Tssr144674	Chr17:43671277-43671300 (+)	-53 bp
Tssr144675	Chr17:43671314-43671347 (+)	-11 bp
Tssr144676	Chr17:43700327-43700388 (+)	29,016 bp
Tssr144677	Chr17:43700392-43700404 (+)	29,056 bp
Tssr144678	Chr17:43700417-43700430 (+)	29,082 bp
Tssr144679	Chr17:43700433-43700453 (+)	29,101 bp
Tssr144680	Chr17:43700470-43700485 (+)	29,136 bp
Tssr144681	Chr17:43766328-43766340 (+)	94,992 bp
Tssr144682	Chr17:43766522-43766547 (+)	95,193 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24