Bub1b^tm1.1Hsl
Targeted Allele Detail

Summary

• Symbol: Bub1b^tm1.1Hsl
• Name: BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1.1, Hyunsook Lee
• MGI ID: MGI:5543300
• Synonyms: BubR1^K243R
• Gene: Bub1b Location: Chr2:118428692-118472072 bp, + strand Genetic Position: Chr2, 59.4 cM
• Alliance: Bub1b^tm1.1Hsl page

Spontaneous tumorigenesis in Bub1b^tm1.1Hsl/Bub1b⁺ mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201641
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 6 is replaced with an FRT-flanked neomycin resistance cassette with a 5' loxP site and a modified exon 6 in which nucleotide substitutions (AAA to AGG) result in the amino acid substitution of arginine for lysine at position 243 (K243R). Flp-mediated recombination removed the neomycin resistance cassette. (J:201641)

Generation of the Bub1b^tm1.1Hsl allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bub1b^tm1.1Hsl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1b Mutation: 58 strains or lines available

References

• Original: J:201641 Park I, et al., Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation. J Cell Biol. 2013 Jul 22;202(2):295-309
• All: 2 reference(s)