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| Caption | Generation of the Bub1btm1.1Hsl allele. (A) Schematic representation of the Bub1b (BubR1) gene-targeting strategy. Shown are the structures of the wild-type Bub1b locus, the targeting construct, the targeted locus, and the disrupted locus after the Flpe-mediated deletion. The neomycin-resistance gene in the targeting construct is removed when crossed with the Flpe transgenic mouse to generate the mutant (Bub1btm1.1Hsl; BubR1K243R) allele. The probe for Southern blot analysis and the primers for PCR genotyping are marked with gray bars and arrows, respectively. | ||||
| Copyright | This image is from Park I, J Cell Biol 2013 Jul 22;202(2):295-309, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:201641 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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