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Ubr4tm1.1Nkt
Targeted Allele Detail
Nomenclature
Symbol: Ubr4tm1.1Nkt
Name: ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.1, Yoshihiro Nakatani
MGI ID: MGI:5532331
Synonyms: p600-
Gene: Ubr4  Location: Chr4:139380659-139489533 bp, + strand  Genetic Position: Chr4, 70.66 cM
Growth retardation in E9.5-E12.5 Ubr4tm1.1Nkt/Ubr4tm1.1Nkt embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203460
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neomycin resistance cassette and exon 1. (J:203460)
Generation of the Ubr4tm1.1Nkt allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubr4 Mutation:  16 strains or lines available
References
Original:  J:203460 Nakaya T, et al., p600 Plays Essential Roles in Fetal Development. PLoS One. 2013;8(6):e66269
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory