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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ubr4tm1.1Nkt
targeted mutation 1.1, Yoshihiro Nakatani
MGI:5532331
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ubr4tm1.1Nkt/Ubr4tm1.1Nkt involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5532400


Genotype
MGI:5532400
hm1
Allelic
Composition		 Ubr4tm1.1Nkt/Ubr4tm1.1Nkt
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr4tm1.1Nkt mutation (0 available); any Ubr4 mutation (247 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Growth retardation in E9.5-E12.5 Ubr4tm1.1Nkt/Ubr4tm1.1Nkt embryos

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:203460 )
• fewer than expected mice are present after E11.5 with no mice detected at E13.5

embryo
abnormal placental labyrinth vasculature morphology ( J:203460 )
• dilated and disorganized maternal blood vessels full of serum and with monocytes marginated along the endothelial inner lining
decreased embryo size ( J:203460 )
• beginning at E10.5

cardiovascular system
abnormal placental labyrinth vasculature morphology ( J:203460 )
• dilated and disorganized maternal blood vessels full of serum and with monocytes marginated along the endothelial inner lining

growth/size/body
decreased embryo size ( J:203460 )
• beginning at E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory