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Ubr4 Gene Detail
Summary
  • Symbol
    Ubr4
  • Name
    ubiquitin protein ligase E3 component n-recognin 4
  • Synonyms
    1810009A16Rik, A930005E13Rik, D930005K06Rik, LOC381562, mKIAA0462, p600, Zubr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916366
    NCBI Gene: 69116
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:139107970-139216844 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2193 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916366
 protein coding gene Chr4:139079920-139216899 (+)
129S1/SvImJ ENSMUSG00200041408
 protein coding gene Chr4:132522052-132631071 (+)
A/J ENSMUSG00195034252
 protein coding gene Chr4:133865633-133974665 (+)
AKR/J ENSMUSG00220046161
 protein coding gene Chr4:132861243-132970638 (+)
BALB/cJ ENSMUSG00180045634
 protein coding gene Chr4:131501195-131610582 (+)
C3H/HeJ ENSMUSG00175038631
 protein coding gene Chr4:132529286-132638674 (+)
C57BL/6NJ ENSMUSG00215047172
 protein coding gene Chr4:134051095-134160140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026713
 protein coding gene Chr4:129026510-129162215 (+)
CAST/EiJ ENSTCUG00005012907
 protein coding gene Chr4:133491278-133600510 (+)
CBA/J ENSMUSG00210027697
 protein coding gene Chr4:132153322-132262701 (+)
DBA/2J ENSMUSG00185051084
 protein coding gene Chr4:133667027-133776415 (+)
FVB/NJ ENSMUSG00205046107
 protein coding gene Chr4:131921936-132031089 (+)
JF1/MsJ ENSUMUG00000026147
 protein coding gene Chr4:134363768-134472804 (+)
LP/J ENSMUSG00230036440
 protein coding gene Chr4:137460729-137569710 (+)
NOD/ShiLtJ ENSMUSG00190021513
 protein coding gene Chr4:131924464-132033491 (+)
NZO/HlLtJ ENSMUSG00225007834
 protein coding gene Chr4:143415354-143524379 (+)
PWK/PhJ ENSLUMG00010038603
 protein coding gene Chr4:131349364-131458739 (+)
SPRET/EiJ ENSMSPG00010033612
 protein coding gene Chr4:133408550-133516689 (+)
WSB/EiJ ENSIUOG00005038753
 protein coding gene Chr4:131810014-131919258 (+)



Homology
more
  • Human Ortholog
    UBR4, ubiquitin protein ligase E3 component n-recognin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBR4, ubiquitin protein ligase E3 component n-recognin 4
  • Synonyms
    p600, RBAF600, ZUBR1
  • Links
    NCBI Gene ID: 23352
    UniProt: Q5T4S7

  • Chr Location
    1p36.13; chr1:19074510-19210266 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 5 alleles in 5 genetic backgrounds
    7 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit neonatal lethality and decreased body size at birth. Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with arrest of vitelline vascular remodeling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    694
  • Tissues
    96
  • cDNA Data
    268
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69116 NCBI Gene Model | MGI Sequence Detail 108875 C57BL/6J ±  kb
    transcript NM_001160319 RefSeq | MGI Sequence Detail 15901 C57BL/6  
    polypeptide A2AN08 UniProt | EBI | MGI Sequence Detail 5180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000017015 E3 ubiquitin-protein ligase UBR4
      (term hierarchy)
    • EC
      2.3.2.27
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR025704 E3 ubiquitin ligase UBR4, C-terminal
      IPR045189 E3 ubiquitin ligase UBR4-like
      IPR056530 E3 ubiquitin-protein ligase UBR4-like domain
      IPR063851 E3 ubiquitin-protein ligase UBR4-like, TPR-like domain
      IPR047509 E3 ubiquitin-protein ligase UBR4-like, UBR-box
      IPR045841 E3 ubiquitin-protein ligase UBR4, N-terminal
      IPR063252 E3 ubiquitin-protein ligase UBR4, ubiquitin-like domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR003126 Zinc finger, UBR-type
    • GlyGen
      A2AN08 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 269
      cDNA 268
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140710, MGI:2444481, MGI:2685878
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 8
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:380627 Masuda S, et al., TRAF7 determines circadian period through ubiquitination and degradation of DBP. Commun Biol. 2024 Oct 8;7(1):1280
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory