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Triotm1Mzhu
Targeted Allele Detail
Nomenclature
Symbol: Triotm1Mzhu
Name: triple functional domain (PTPRF interacting); targeted mutation 1, Min-Sheng Zhu
MGI ID: MGI:4839231
Synonyms: Trioflox
Gene: Trio  Location: Chr15:27730651-28025848 bp, - strand  Genetic Position: Chr15, 10.4 cM
Growth retardation, ataxia, small brain size, and reduced olfactory bulb size in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165902
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 22 and an additional loxP site was inserted downstream of exon 26. (J:165902)
Generation of the Triotm1Mzhu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trio Mutation:  6 strains or lines available
References
Original:  J:165902 Peng YJ, et al., Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem. 2010 Aug 6;285(32):24834-44
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory