Del(2Hoxd11-Hoxd13)29Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd11-Hoxd13)29Ddu
• Name: deletion, Chr 2, Denis Duboule 29
• MGI ID: MGI:1857661
• Synonyms: Del, del(11-13), Del29Ddu, HoxD^d11lacZDel3, HoxD^Del, Hoxd^Del(11-13), HoxD^Del3, Hoxd^tm2Ddu
• Gene: Del(2Hoxd11-Hoxd13)29Ddu Location: Chr2:74498654-74517360 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36443
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd11-Hoxd13)29Ddu involves 4 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: This allele involved the use of an embryonic stem cell line carrying an ectopic Hoxd11/lacZ transgene located between the resident Hoxd13 and Evx2 genes and flanked at the 3' end by a unique loxP site. A loxPneoloxP cassette was recombined on the same chromosome, downstream of resident Hoxd11. After treatment with Cre recombinase, the resultant deletion removed Hoxd11, Hoxd12, and Hoxd13, but brought the ectopic Hoxd11/lacZ transgene back to the original Hoxd11 locus. Mice homozygous for this deficiency lacked Hoxd11, Hoxd12, and Hoxd13 loci. (J:36443)

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd11-Hoxd13)29Ddu Mutation: 2 strains or lines available

References

• Original: J:36443 Zakany J, et al., Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature. 1996 Nov 7;384(6604):69-71
• All: 22 reference(s)