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Hoxd11 Gene Detail
Summary
  • Symbol
    Hoxd11
  • Name
    homeobox D11
  • Synonyms
    E230017H14Rik, Hox-4.6, Hox-5.4, Hox-5.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96203
    NCBI Gene: 15431
  • Member of
    Hoxd cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr31 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr2:74509902-74517360 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96203
 protein coding gene Chr2:74509901-74517360 (+)
129S1/SvImJ ENSMUSG00200003100
 protein coding gene Chr2:71561309-71563161 (+)
A/J ENSMUSG00195018856
 protein coding gene Chr2:71707998-71709853 (+)
AKR/J ENSMUSG00220002285
 protein coding gene Chr2:71672644-71674496 (+)
BALB/cJ ENSMUSG00180006866
 protein coding gene Chr2:71661670-71663521 (+)
C3H/HeJ ENSMUSG00175010366
 protein coding gene Chr2:71787553-71789396 (+)
C57BL/6NJ ENSMUSG00215012474
 protein coding gene Chr2:71624499-71626344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023669
 protein coding gene Chr2:69483911-69491484 (+)
CAST/EiJ ENSTCUG00005027381
 protein coding gene Chr2:71101377-71103228 (+)
CBA/J ENSMUSG00210001937
 protein coding gene Chr2:71830204-71832049 (+)
DBA/2J ENSMUSG00185011451
 protein coding gene Chr2:71666052-71667898 (+)
FVB/NJ ENSMUSG00205012647
 protein coding gene Chr2:71118039-71119891 (+)
JF1/MsJ ENSUMUG00000024986
 protein coding gene Chr2:71343169-71345032 (+)
LP/J ENSMUSG00230023768
 protein coding gene Chr2:73460898-73462750 (+)
NOD/ShiLtJ ENSMUSG00190010706
 protein coding gene Chr2:71740766-71742618 (+)
NZO/HlLtJ ENSMUSG00225014176
 protein coding gene Chr2:81224959-81226804 (+)
PWK/PhJ ENSLUMG00010030263
 protein coding gene Chr2:71581542-71583404 (+)
SPRET/EiJ ENSMSPG00010019477
 protein coding gene Chr2:72981533-72983393 (+)
WSB/EiJ ENSIUOG00005010648
 protein coding gene Chr2:71784066-71785912 (+)



Homology
more
  • Human Ortholog
    HOXD11, homeobox D11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXD11, homeobox D11
  • Synonyms
    HOX4, HOX4F
  • Links
    NCBI Gene ID: 3237
    UniProt: P31277

  • Chr Location
    2q31.1; chr2:176104216-176115679 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 6 alleles in 6 genetic backgrounds
    68 phenotypes from multigenic genotypes
    4 images
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit homeotic transformations of sacral vertebrae, malformations of distal limbs, and reduced fertility in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1300
  • Tissues
    342
  • cDNA Data
    18
  • Literature Summary
    195
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15431 NCBI Gene Model | MGI Sequence Detail 7459 C57BL/6J ±  kb
    transcript NM_008273 RefSeq | MGI Sequence Detail 3959 Not Specified  
    polypeptide P23813 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      Genomic 11
      cDNA 20
      Primer pair 14
      Other 42

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10853, MGD-MRK-10861, MGD-MRK-10904, MGI:2442499
    References
    more
    • Summaries
      All 301
      Developmental Gene Expression 195
      Gene Ontology 15
      Phenotypes 104
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:390509 Huang BL, et al., A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity. Nat Commun. 2026 May 26;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory