Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
|
|
|
limbs/digits/tail
|
|
• some mice display bone fusions in the paws
|
|
|
• at birth, paw size is noticeably reduced
|
|
|
• at birth, digit size is noticeably reduced
(J:36443)
• secondary fusions between proximal digital elements results in Y-like digits or polysyndactyly
(J:36443)
• toe 1 is malformed
(J:153164)
|
|
|
• distal elements of digits are dramatically reduced in size
(J:36443)
• in all digits
(J:153164)
|
|
|
• both fore- and hindpaws have markedly shorter digits with absence of the second phalanges and an abnormal aspect of the digits, and the ectrodactyly in the hindpaw is less severe than in the hindpaw of Doxd13 homozyogtes
|
|
|
• conspicuous at birth
(J:36443)
• additional digits are intercalated or fused, to either digit III or IV; invariably, animals have six defective and partially fused digits
(J:36443)
• observed in the hindpaw of most, if not all, homozygotes
(J:71694)
• in the hind limbs
(J:153164)
|
|
|
• at E11 and E12, presumptive digit area is reduced in size
|
|
|
• at birth, webbing between vestigal digits is observed in all homozygotes
|
skeleton
|
|
• cartilage remodeling in newborn animals is significantly delayed; characteristic columns of quiescent cells normally seen in controls are rarely apparent in mutants
|
cellular
|
|
• at birth, webbing between vestigal digits is observed in all homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
|
|
|
limbs/digits/tail
|
|
• in newborns, digits II and V are reduced in size (shortened)
(J:36443)
• in digits 2 and 5
(J:153164)
|
|
|
• digit V and digit II are always affected to some degree, particularly in the front paws
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Hoxd12tm2Ddu mutation
(1 available);
any
Hoxd12 mutation
(13 available)
|
|
|
limbs/digits/tail
|
|
• absent second phalange of digit V
• reduction in size of second phalange of digit II
|
skeleton
|
|
• absent second phalange of digit V
• reduction in size of second phalange of digit II
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu mutation
(0 available);
any
Evx2 mutation
(19 available)
|
|
|
limbs/digits/tail
|
|
• the second phalanges is reduced or absent compared to in wild-type mice
|
|
|
• digits II and V are shorter than in wild-type mice due to a reduction or absence of the second phalanges
|
skeleton
|
|
• the second phalanges is reduced or absent compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu mutation
(0 available);
any
Hoxd13 mutation
(24 available)
|
|
|
limbs/digits/tail
|
|
• the second phalanges is reduced or absent compared to in wild-type mice
|
|
|
• digits II and V are shorter than in wild-type mice due to a reduction or absence of the second phalanges
|
skeleton
|
|
• the second phalanges is reduced or absent compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Hoxd13Dyc mutation
(1 available);
any
Hoxd13 mutation
(24 available)
|
|
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Hoxd13spdh mutation
(1 available);
any
Hoxd13 mutation
(24 available)
|
|
|
limbs/digits/tail
|
|
• less pronounced than in homozygotes of either component mutation
|
|
|
• variable syndactyly of digits III and IV, along with a supernumerary digit in between
|
reproductive system
 |
• although males homozygous for either mutation are sterile, approximately 60% of these trans-heterozygotes are fertile
|
skeleton
|
|
• at 8 days of age the paws have some delay in the ossification process although ossification centers are observed
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Hoxd11tm2.1Ddu mutation
(0 available);
any
Hoxd11 mutation
(14 available)
|
|
|
skeleton
|
|
• second phalanges of digits II and V are reduced in size
|
|
|
• 5 of 5 mice have abnormal L4
• 2 of 5 mice have abnormal L6
|
|
|
• 3 of 5 mice have an L7 formula instead of an L6 formula found in wild-type mice
|
limbs/digits/tail
|
|
• second phalanges of digits II and V are reduced in size
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Hoxd11tm1Ipc mutation
(0 available);
any
Hoxd11 mutation
(14 available)
|
|
|
skeleton
|
|
• 3 of 3 mice have carpal bone defects
|
|
|
• proximal carpal elements are fused in some mice
|
|
|
• 3 of 3 mice have abnormal L4
|
|
|
• 3 of 3 mice have abnormal L7 formula instead of an L6 formula found in wild-type mice
|
limbs/digits/tail
|
|
• 3 of 3 mice have carpal bone defects
|
|
|
• proximal carpal elements are fused in some mice
|
|
|
• the second phalanges of digits II and V is completely lost
• other digits have phalanges defects
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available);
any
Del(2Hoxd11-Hoxd13)29Ddu mutation
(2 available)
Hoxdtm3Ddu mutation
(0 available);
any
Hoxd mutation
(0 available)
|
|
|
limbs/digits/tail
|
|
• reductions in size of digits II and V
|
Analysis Tools