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Hoxd12 Gene Detail
Summary
  • Symbol
    Hoxd12
  • Name
    homeobox D12
  • Synonyms
    Hox-4.7, Hox-5.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96204
    NCBI Gene: 15432
  • Member of
    Hoxd cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74505357-74508049 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96204
 protein coding gene Chr2:74505357-74508049 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025846
 protein coding gene Chr2:74989214-74991905 (+)
A/J MGP_AJ_G0025824
 protein coding gene Chr2:72056266-72058965 (+)
AKR/J MGP_AKRJ_G0025792
 protein coding gene Chr2:74009533-74012232 (+)
BALB/cJ MGP_BALBcJ_G0025818
 protein coding gene Chr2:72243189-72245885 (+)
C3H/HeJ MGP_C3HHeJ_G0025578
 protein coding gene Chr2:74197376-74200067 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026265
 protein coding gene Chr2:77223342-77226034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023668
 protein coding gene Chr2:69479335-69482048 (+)
CAST/EiJ MGP_CASTEiJ_G0025042
 protein coding gene Chr2:74512004-74514694 (+)
CBA/J MGP_CBAJ_G0025559
 protein coding gene Chr2:80044492-80047182 (+)
DBA/2J MGP_DBA2J_G0025690
 protein coding gene Chr2:71662869-71665560 (+)
FVB/NJ MGP_FVBNJ_G0025652
 protein coding gene Chr2:71052583-71055275 (+)
LP/J MGP_LPJ_G0025778
 protein coding gene Chr2:74853353-74856003 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025683
 protein coding gene Chr2:81958088-81960784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026322
 protein coding gene Chr2:74125073-74127764 (+)
PWK/PhJ MGP_PWKPhJ_G0024783
 protein coding gene Chr2:71593257-71595949 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024591
 protein coding gene Chr2:74358903-74361595 (+)
WSB/EiJ MGP_WSBEiJ_G0025110
 protein coding gene Chr2:74561033-74563722 (+)



Homology
more
  • Human Ortholog
    HOXD12, homeobox D12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXD12, homeobox D12
  • Synonyms
    HOX4H
  • Links
    NCBI Gene ID: 3238
    neXtProt AC: NX_P35452
    UniProt: P35452

  • Chr Location
    2q31.1; chr2:176099795-176102489 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HOXD12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit minor forelimb defects affecting carpals, metacarpals, and phalanges, and alterations of smooth muscle layers of the rectum resulting in malformation of the internal anal sphincter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1148
  • Tissues
    256
  • cDNA Data
    12
  • Literature Summary
    142
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15432 NCBI Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
    transcript NM_008274 RefSeq | MGI Sequence Detail 2534 ZRU/MplStud  
    polypeptide P23812 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 9
      cDNA 13
      Primer pair 9
      Other 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10854, MGD-MRK-10863, MGD-MRK-10905
    References
    more
    • Summaries
      All 222
      Developmental Gene Expression 142
      Gene Ontology 9
      Phenotypes 75
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:342014 Chen Y, et al., Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf. Cell Death Differ. 2023 Oct;30(10):2293-2308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory