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Leprdb
Spontaneous Allele Detail
Nomenclature
Symbol: Leprdb
Name: leptin receptor; diabetes
MGI ID: MGI:1856009
Synonyms: db, db/db, Lepdb, Lepr-, leprdb, Leprdb-1J
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Increased beta cell mass in Leprdb/Leprdb mice and Leprdb/Leprdb Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BLKS/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 55 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 10 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  29 strains or lines available
References
Original:  J:5010 Hummel KP, et al., Diabetes, a new mutation in the mouse. Science. 1966 Sep 2;153(740):1127-8
All:  846 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory