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Image
Caption Effects of Cebpb ablation in pancreatic beta cells of Leprdb/ Leprdb mice. (E) Pancreatic sections from 24-week-old Leprdb/Lepr+ (Lepr+/-), Leprdb/Lepr+ Cebpbtm1.1Maka/ Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Lepr+/-;betaCebpb-/-), Leprdb/Leprdb (Lepr-/-) and Leprdb/Leprdb Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Lepr-/-;betaCebpb-/-) mice were stained with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um.
Copyright This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725
Associated
Alleles
Symbol Name
Cebpbtm1.1Maka CCAAT/enhancer binding protein (C/EBP), beta; targeted mutation 1.1, Masato Kasuga
Leprdb leptin receptor; diabetes
Tg(Ins2-cre)23Herr transgene insertion 23, Pedro Luis Herrera
Associated
Genotypes
Allelic Composition Genetic Background
Leprdb/Leprdb BKS.Cg-Dock7m +/+ Leprdb/Jcl
Cebpbtm1.1Maka/Cebpbtm1.1Maka
Leprdb/Leprdb
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory