About   Help   FAQ
Spontaneous Allele Detail
Symbol: Tyrc-h
Name: tyrosinase; himalayan
MGI ID: MGI:1855979
Gene: Tyr  Location: Chr7:87424771-87493512 bp, - strand  Genetic Position: Chr7, 49.01 cM
Tyrc-h/ Tyrc-h

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  (DBA/2 x AKR/J)F1
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsThe mutation in the himalayan allele was found to be an A to G point mutation at nucleotide 1259 that results in an amino acid change at position 420 from histidine to arginine. (J:9824)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  391 strains or lines available
Melanin granules of the retina are indistinguishable from those of chinchilla or of wild-type homozygotes (J:5001). Pigment synthesis in himalayan mice is temperature-sensitive; pigment develops in growing hairs of mice housed at 15oC but not in those housed at 30oC (J:6275). In explanation of this effect, it has been shown that tyrosinase in these mice is heat-labile (J:12173), being maximally active at well below body temperature. Tyrosinase of Tyrch homozygotes is strongly bound by an inhibitor at 37oC but not at lower temperatures (J:6508).
Original:  J:24726 Green MC, New mutant: Himalayan, symbol c. Mouse News Lett. 1959;21:46
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory