Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation
(2 available);
any
Tyr mutation
(375 available)
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pigmentation
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• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth
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• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
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• eyes are minimally pigmented and appear red
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integument
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• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth
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vision/eye
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• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
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• eyes are minimally pigmented and appear red
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Allelic
Composition |
Tyrc-h/Tyrc-h
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Genetic
Background |
involves: AKR/J * DBA/2J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation
(2 available);
any
Tyr mutation
(375 available)
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pigmentation
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• the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail
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• pink eye color of the new born darkens to ruby-colored by weaning
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vision/eye
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• pink eye color of the new born darkens to ruby-colored by weaning
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integument
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• at one week of age affected mice are slightly darker than albinos, particularly on tail
• the body coat color may range from unifrom to slightly lighter dorsal and ventral across the shoulders, darker toward the tail where a very dark ring of body fur develops adjacent to the tail
• at first molt the nose, ears, tail, and scrotum but not the feet become considerably darker; the rest of the body becomes lighter
• dark hair on the nose extends back to the anterior border of the eyes
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• the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail
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Allelic
Composition |
Tyrc-h/Tyrc-h
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Genetic
Background |
involves: C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation
(2 available);
any
Tyr mutation
(375 available)
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pigmentation
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• mice have slight pigmentation of the coat
• the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice
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integument
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• mice have slight pigmentation of the coat
• the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice
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Allelic
Composition |
Tyrc-h/Tyrc
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Genetic
Background |
involves: AKR/J * DBA/2J |
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pigmentation
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• coats of juvenile mice are very pale buff
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• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan
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vision/eye
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• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan
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integument
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• although indistinguishable from albino at birth coat color is intermediate between albino and homozygous himalayan at about one week of age
• with the first molt extremities darken but not as dark as seen in the homozygote
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• coats of juvenile mice are very pale buff
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Allelic
Composition |
Tyrc-a/Tyrc-h
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Genetic
Background |
involves: C3H/HeJ |
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pigmentation
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• the coat is lighter than mice that are homozygous Tyrc-h but indistinguishable from acromelanic homozygotes
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integument
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• the coat is lighter than mice that are homozygous Tyrc-h but indistinguishable from acromelanic homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-25H mutation
(0 available);
any
Tyr mutation
(375 available)
Tyrc-h mutation
(2 available);
any
Tyr mutation
(375 available)
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pigmentation
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• coat color is lighter than homozygous chinchilla but not albino
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integument
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• coat color is lighter than homozygous chinchilla but not albino
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Analysis Tools