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Sik3 Gene Detail
Summary
  • Symbol
    Sik3
  • Name
    SIK family kinase 3
  • Synonyms
    5730525O22Rik, 9030204A07Rik, mKIAA0999
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446296
    NCBI Gene: 70661
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45924118-46135492 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446296
 protein coding gene Chr9:45924099-46135492 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034747
 protein coding gene Chr9:44623491-44854245 (+)
A/J MGP_AJ_G0034728
 protein coding gene Chr9:43359332-43569965 (+)
AKR/J MGP_AKRJ_G0034655
 protein coding gene Chr9:44242577-44458157 (+)
BALB/cJ MGP_BALBcJ_G0034719
 protein coding gene Chr9:43081515-43291476 (+)
C3H/HeJ MGP_C3HHeJ_G0034430
 protein coding gene Chr9:44720203-44932199 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035240
 protein coding gene Chr9:45910945-46135059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032154
 protein coding gene Chr9:42896168-43100611 (+)
CAST/EiJ MGP_CASTEiJ_G0033752
 protein coding gene Chr9:44575555-44790253 (+)
CBA/J MGP_CBAJ_G0034402
 protein coding gene Chr9:47584301-47820279 (+)
DBA/2J MGP_DBA2J_G0034561
 protein coding gene Chr9:43232483-43441249 (+)
FVB/NJ MGP_FVBNJ_G0034502
 protein coding gene Chr9:42499097-42705004 (+)
LP/J MGP_LPJ_G0034642
 protein coding gene Chr9:44938941-45172766 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034546
 protein coding gene Chr9:49359500-49568947 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035261
 protein coding gene Chr9:44156840-44377277 (+)
PWK/PhJ MGP_PWKPhJ_G0033457
 protein coding gene Chr9:43145004-43360213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033293
 protein coding gene Chr9:44481956-44705873 (+)
WSB/EiJ MGP_WSBEiJ_G0033865
 protein coding gene Chr9:44208079-44426268 (+)



Homology
more
  • Human Ortholog
    SIK3, SIK family kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIK3, SIK family kinase 3
  • Synonyms
    L19, QSK, SEMDK, SIK-3
  • Links
    NCBI Gene ID: 23387
    neXtProt AC: NX_Q9Y2K2
    UniProt: Q9Y2K2

  • Chr Location
    11q23.3; chr11:116843402-117098437 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    147 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired chondrocyte hypertrophy during development, neonatal lethality and reduced size. Mice homozygous for a gain of function ENU mutation exhibit decreased total wake time, owing to an increase in inherent sleep need.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    71
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034135 Ensembl Gene Model | MGI Sequence Detail 211375 C57BL/6J ±  kb
    transcript ENSMUST00000126865 Ensembl | MGI Sequence Detail 6287 Not Applicable  
    polypeptide ENSMUSP00000121032 Ensembl | MGI Sequence Detail 1369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917911, MGI:1924411, MGI:2143048, MGI:2143140, MGI:2143148
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340630 Asano F, et al., SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218209120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory