About   Help   FAQ
Erlin2 Gene Detail
Summary
  • Symbol
    Erlin2
  • Name
    ER lipid raft associated 2
  • Synonyms
    MGC:27952, Spfh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387215
    NCBI Gene: 244373
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27513399-27529465 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 15.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387215
 protein coding gene Chr8:27513289-27530356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033499
 protein coding gene Chr8:25197586-25216776 (+)
A/J MGP_AJ_G0033479
 protein coding gene Chr8:24242102-24257716 (+)
AKR/J MGP_AKRJ_G0033404
 protein coding gene Chr8:25042585-25058223 (+)
BALB/cJ MGP_BALBcJ_G0033475
 protein coding gene Chr8:24398660-24414294 (+)
C3H/HeJ MGP_C3HHeJ_G0033189
 protein coding gene Chr8:25263287-25278952 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033991
 protein coding gene Chr8:26182883-26198499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030941
 protein coding gene Chr8:21496001-21511593 (+)
CAST/EiJ MGP_CASTEiJ_G0032515
 protein coding gene Chr8:24750816-24763629 (+)
CBA/J MGP_CBAJ_G0033164
 protein coding gene Chr8:27215330-27233243 (+)
DBA/2J MGP_DBA2J_G0033319
 protein coding gene Chr8:24205485-24221183 (+)
FVB/NJ MGP_FVBNJ_G0033263
 protein coding gene Chr8:24019133-24034794 (+)
LP/J MGP_LPJ_G0033408
 protein coding gene Chr8:25161176-25176829 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033306
 protein coding gene Chr8:26662062-26678129 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034010
 protein coding gene Chr8:25029022-25044676 (+)
PWK/PhJ MGP_PWKPhJ_G0032226
 protein coding gene Chr8:23867507-23880366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032060
 protein coding gene Chr8:24409374-24426598 (+)
WSB/EiJ MGP_WSBEiJ_G0032631
 protein coding gene Chr8:25209060-25224696 (+)



Homology
more
  • Human Ortholog
    ERLIN2, ER lipid raft associated 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERLIN2, ER lipid raft associated 2
  • Synonyms
    C8orf2, Erlin-2, NET32, SPFH2, SPG18, SPG18A, SPG18B
  • Links
    NCBI Gene ID: 11160
    neXtProt AC: NX_O94905
    UniProt: O94905

  • Chr Location
    8p11.23; chr8:37736601-37758422 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ERLIN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    140
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244373 NCBI Gene Model | MGI Sequence Detail 16067 C57BL/6J ±  kb
transcript NM_001379176 RefSeq | MGI Sequence Detail 4296 C57BL/6  
polypeptide Q8BFZ9 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 140
    cDNA 140

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142881
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory