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Aldh3a1 Gene Detail
Summary
  • Symbol
    Aldh3a1
  • Name
    aldehyde dehydrogenase family 3, subfamily A1
  • Synonyms
    Ahd4, Ahd-4, Aldh, Aldh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353451
    NCBI Gene: 11670
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61099336-61109244 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353451
 protein coding gene Chr11:61098363-61109247 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018434
 protein coding gene Chr11:61158166-61169047 (+)
A/J MGP_AJ_G0018403
 protein coding gene Chr11:58899063-58909947 (+)
AKR/J MGP_AKRJ_G0018373
 protein coding gene Chr11:60741252-60752133 (+)
BALB/cJ MGP_BALBcJ_G0018374
 protein coding gene Chr11:59202269-59213153 (+)
C3H/HeJ MGP_C3HHeJ_G0018187
 protein coding gene Chr11:60716838-60727722 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018826
 protein coding gene Chr11:63093023-63103907 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016472
 protein coding gene Chr11:56037298-56048324 (+)
CAST/EiJ MGP_CASTEiJ_G0017744
 protein coding gene Chr11:60824821-60859359 (+)
CBA/J MGP_CBAJ_G0018161
 protein coding gene Chr11:65836021-65846905 (+)
DBA/2J MGP_DBA2J_G0018270
 protein coding gene Chr11:58481446-58492329 (+)
FVB/NJ MGP_FVBNJ_G0018261
 protein coding gene Chr11:58157280-58168132 (+)
LP/J MGP_LPJ_G0018343
 protein coding gene Chr11:61732089-61742970 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018285
 protein coding gene Chr11:66866379-66877262 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018867
 protein coding gene Chr11:60868323-60879205 (+)
PWK/PhJ MGP_PWKPhJ_G0017517
 protein coding gene Chr11:59079007-59118999 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017307
 protein coding gene Chr11:60686328-60697100 (+)
WSB/EiJ MGP_WSBEiJ_G0017796
 protein coding gene Chr11:60482138-60492990 (+)



Homology
more
  • Human Ortholog
    ALDH3A1, aldehyde dehydrogenase 3 family member A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH3A1, aldehyde dehydrogenase 3 family member A1
  • Synonyms
    ALDH3, ALDHIII
  • Links
    NCBI Gene ID: 218
    neXtProt AC: NX_P30838
    UniProt: P30838

  • Chr Location
    17p11.2; chr17:19737984-19748943 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALDH3A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    29 phenotype references
Homozygous mutation of this gene does not result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    115
  • cDNA Data
    11
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11670 NCBI Gene Model | MGI Sequence Detail 9909 C57BL/6J ±  kb
transcript NM_001331112 RefSeq | MGI Sequence Detail 1732 ZRU/MplStud  
polypeptide P47739 UniProt | EBI | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1209, MGD-MRK-1216, MGD-MRK-1275, MGD-MRK-16381, MGI:87993, MGI:99599
References
more
  • Summaries
    All 99
    Developmental Gene Expression 11
    Diseases 2
    Gene Ontology 12
    Phenotypes 29
  • Earliest
    J:6092 Lush IE, Genetic variation of some aldehyde-oxidizing enzymes in the mouse. Anim Blood Groups Biochem Genet. 1978;9(2):85-96
  • Latest
    J:336250 Son J, et al., Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of beta-cell failure. Nat Commun. 2023 Feb 2;14(1):558
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory