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Ncr1 Gene Detail
Summary
  • Symbol
    Ncr1
  • Name
    natural cytotoxicity triggering receptor 1
  • Synonyms
    Cd335, Ly94, MAR1 (mouse activating receptor 1), NKp46
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336212
    NCBI Gene: 17086
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4340723-4348163 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336212
 protein coding gene Chr7:4340714-4348183 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031542
 protein coding gene Chr7:1252308-1261069 (+)
A/J MGP_AJ_G0031516
 protein coding gene Chr7:1261295-1270869 (+)
AKR/J MGP_AKRJ_G0031445
 protein coding gene Chr7:1331363-1338730 (+)
BALB/cJ MGP_BALBcJ_G0031524
 protein coding gene Chr7:1328422-1336607 (+)
C3H/HeJ MGP_C3HHeJ_G0031245
 protein coding gene Chr7:1287892-1295293 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031985
 protein coding gene Chr7:1265620-1274762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029109
 protein coding gene Chr7:1033419-1040548 (+)
CAST/EiJ MGP_CASTEiJ_G0030609
 protein coding gene Chr7:1233218-1240332 (+)
CBA/J MGP_CBAJ_G0031203
 protein coding gene Chr7:1483865-1493487 (+)
DBA/2J MGP_DBA2J_G0031362
 protein coding gene Chr7:1233359-1240768 (+)
FVB/NJ MGP_FVBNJ_G0031314
 protein coding gene Chr7:1200261-1207675 (+)
LP/J MGP_LPJ_G0031447
 protein coding gene Chr7:1345548-1356673 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031353
 protein coding gene Chr7:1402585-1412338 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032015
 protein coding gene Chr7:1230290-1239041 (+)
PWK/PhJ MGP_PWKPhJ_G0030337
 protein coding gene Chr7:1401728-1409390 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030162
 protein coding gene Chr7:1292811-1299902 (+)
WSB/EiJ MGP_WSBEiJ_G0030704
 protein coding gene Chr7:1236740-1250753 (+)



Homology
more
  • Human Ortholog
    NCR1, natural cytotoxicity triggering receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCR1, natural cytotoxicity triggering receptor 1
  • Synonyms
    CD335, LY94, NK-p46, NKP46
  • Links
    NCBI Gene ID: 9437
    neXtProt AC: NX_O76036
    UniProt: O76036

  • Chr Location
    19q13.42; chr19:54898198-54938208 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    173 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene lead to alterations in susceptibility to viral infection induced morbidity/mortality, NK cell number, NK cell cytolysis, and T cell responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062524 Ensembl Gene Model | MGI Sequence Detail 7441 C57BL/6J ±  kb
transcript ENSMUST00000006792 Ensembl | MGI Sequence Detail 1463 Not Applicable  
polypeptide ENSMUSP00000006792 Ensembl | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 204
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 173
  • Earliest
    J:53412 Biassoni R, et al., The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur J Immunol. 1999 Mar;29(3):1014-20
  • Latest
    J:346188 Horta AL, et al., Memory-like NK Cells Are a Critical Component of Vaccine-Induced Immunity to Trypanosoma cruzi Infection. J Immunol. 2024 Feb 15;212(4):617-631
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory