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Dhx8 Gene Detail
Summary
  • Symbol
    Dhx8
  • Name
    DEAH-box helicase 8
  • Synonyms
    Ddx8, mDEAH6, MGC:31290, RNA helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306823
    NCBI Gene: 217207
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101623782-101658184 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306823
 protein coding gene Chr11:101623745-101658184 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019211
 protein coding gene Chr11:104649795-104689693 (+)
A/J MGP_AJ_G0019179
 protein coding gene Chr11:100240526-100275962 (+)
AKR/J MGP_AKRJ_G0019148
 protein coding gene Chr11:103352254-103389297 (+)
BALB/cJ MGP_BALBcJ_G0019153
 protein coding gene Chr11:100722576-100758224 (+)
C3H/HeJ MGP_C3HHeJ_G0018962
 protein coding gene Chr11:103537107-103580854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019602
 protein coding gene Chr11:107921847-107957676 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017228
 protein coding gene Chr11:97661808-97696088 (+)
CAST/EiJ MGP_CASTEiJ_G0018516
 protein coding gene Chr11:104495562-104530760 (+)
CBA/J MGP_CBAJ_G0018931
 protein coding gene Chr11:112352456-112393580 (+)
DBA/2J MGP_DBA2J_G0019043
 protein coding gene Chr11:99761394-99796645 (+)
FVB/NJ MGP_FVBNJ_G0019033
 protein coding gene Chr11:99289592-99325434 (+)
LP/J MGP_LPJ_G0019112
 protein coding gene Chr11:105173923-105209450 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019064
 protein coding gene Chr11:111912321-111950264 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019640
 protein coding gene Chr11:103691744-103728361 (+)
PWK/PhJ MGP_PWKPhJ_G0018279
 protein coding gene Chr11:100812835-100848158 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018071
 protein coding gene Chr11:103420898-103464172 (+)
WSB/EiJ MGP_WSBEiJ_G0018565
 protein coding gene Chr11:103678987-103718224 (+)



Homology
more
  • Human Ortholog
    DHX8, DEAH-box helicase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX8, DEAH-box helicase 8
  • Synonyms
    DDX8, Dhr2, HRH1, PRP22, PRPF22
  • Links
    NCBI Gene ID: 1659
    neXtProt AC: NX_Q14562
    UniProt: Q14562

  • Chr Location
    17q21.31; chr17:43483865-43610338 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    112
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217207 NCBI Gene Model | MGI Sequence Detail 34403 C57BL/6J ±  kb
    transcript NM_144831 RefSeq | MGI Sequence Detail 4344 C57BL/6  
    polypeptide A2A4P0 UniProt | EBI | MGI Sequence Detail 1244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 5
    References
    more
    • Summaries
      All 42
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
    • Latest
      J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory