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Ctss Gene Detail
Summary
  • Symbol
    Ctss
  • Name
    cathepsin S
  • Synonyms
    Cat S
  • Feature Type
    protein coding gene
  • IDs
    MGI:107341
    NCBI Gene: 13040
  • Alliance
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95434097-95463714 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107341
protein coding gene Chr3:95434097-95463716 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027586
protein coding gene Chr3:96271948-96309678 (+)
A/J MGP_AJ_G0027545
protein coding gene Chr3:93274878-93305432 (+)
AKR/J MGP_AKRJ_G0027512
protein coding gene Chr3:95445698-95478498 (+)
BALB/cJ MGP_BALBcJ_G0027557
protein coding gene Chr3:93055128-93085279 (+)
C3H/HeJ MGP_C3HHeJ_G0027290
protein coding gene Chr3:95734908-95765335 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028005
protein coding gene Chr3:99827026-99861070 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025345
protein coding gene Chr3:89597306-89640044 (+)
CAST/EiJ MGP_CASTEiJ_G0026740
protein coding gene Chr3:95002876-95035832 (+)
CBA/J MGP_CBAJ_G0027267
protein coding gene Chr3:103476728-103506676 (+)
DBA/2J MGP_DBA2J_G0027406
protein coding gene Chr3:92562132-92592703 (+)
FVB/NJ MGP_FVBNJ_G0027377
protein coding gene Chr3:90641443-90670616 (+)
LP/J MGP_LPJ_G0027515
protein coding gene Chr3:97576544-97612193 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027404
protein coding gene Chr3:109582131-109619561 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028059
protein coding gene Chr3:95083754-95116602 (+)
PWK/PhJ MGP_PWKPhJ_G0026468
protein coding gene Chr3:92447917-92481438 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026289
protein coding gene Chr3:93371284-93407201 (+)
WSB/EiJ MGP_WSBEiJ_G0026822
protein coding gene Chr3:95474848-95508907 (+)



Homology
more
  • Human Ortholog
    CTSS, cathepsin S
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSS, cathepsin S
  • Links
    NCBI Gene ID: 1520
    neXtProt AC: NX_P25774
    UniProt: P25774

  • Chr Location
    1q21.3; chr1:150730079-150765957 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Ctss mouse models; 1 with human CTSS associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 5 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038642 Ensembl Gene Model | MGI Sequence Detail 29618 C57BL/6J ±  kb
    transcript ENSMUST00000015667 Ensembl | MGI Sequence Detail 1355 Not Applicable  
    polypeptide ENSMUSP00000015667 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 135
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35807
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 11
      Phenotypes 66
    • Earliest
      J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
    • Latest
      J:346262 Wan Y, et al., Cathepsin S deficiency improves muscle mass loss and dysfunction via the modulation of protein metabolism in mice under pathological stress conditions. FASEB J. 2023 Aug;37(8):e23086

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/16/2024
    MGI 6.23
    The Jackson Laboratory