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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctss
cathepsin S
MGI:107341
23 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctssem1(IMPC)H/Ctssem1(IMPC)H
C57BL/6NTac-Ctssem1(IMPC)H/H 		decreased spleen weight J:211773
Ctssm1Btlr/Ctssm1Btlr
C57BL/6J-Ctssm1Btlr 		decreased IgG level J:267491
impaired humoral immune response J:267491
Ctsstm1Eae/Ctss+
NOD.D1-Ctsstm1Eae 		hyperglycemia J:153355
insulitis J:153355
Ctsstm1Eae/Ctsstm1Eae
involves: C57BL/6 * DBA/1LacJ 		abnormal B lymphocyte antigen presentation J:53399
decreased susceptibility to induced arthritis J:53399
Ctsstm1Eae/Ctsstm1Eae
NOD.D1-Ctsstm1Eae 		decreased susceptibility to autoimmune diabetes J:153355
hyperglycemia J:153355
insulitis J:153355
salivary gland inflammation J:153355
Ctsstm1Hap/Ctsstm1Hap
B6.129S2-Ctsstm1Hap 		abnormal B cell physiology J:96401
abnormal cytokine secretion J:96401
abnormal humoral immune response J:96401
abnormal interleukin secretion J:96401
abnormal professional antigen presenting cell physiology J:96401
abnormal T cell physiology J:96401
abnormal vascular endothelial cell physiology J:109410
decreased angiogenesis J:109410
decreased IgG level J:96401
decreased IgM level J:96401
decreased susceptibility to experimental autoimmune myasthenia gravis J:96401
Tg(ACTA1-Ctss)1Jmol/?
FVB/N-Tg(ACTA1-Ctss)1Jmol 		centrally nucleated skeletal muscle fibers J:230788
dystrophic muscle J:230788
impaired exercise endurance J:230788
skeletal muscle fibrosis J:230788
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory