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Gpld1 Gene Detail
Summary
  • Symbol
    Gpld1
  • Name
    glycosylphosphatidylinositol specific phospholipase D1
  • Synonyms
    6330541J12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106604
    NCBI Gene: 14756
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:25127135-25175919 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 10.79 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    486 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106604
 protein coding gene Chr13:25127135-25176484 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020385
 protein coding gene Chr13:22442530-22496384 (+)
A/J MGP_AJ_G0020334
 protein coding gene Chr13:22025677-22078886 (+)
AKR/J MGP_AKRJ_G0020314
 protein coding gene Chr13:22273653-22327260 (+)
BALB/cJ MGP_BALBcJ_G0020332
 protein coding gene Chr13:22009665-22066475 (+)
C3H/HeJ MGP_C3HHeJ_G0020136
 protein coding gene Chr13:22348236-22401923 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020769
 protein coding gene Chr13:23240033-23292670 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018357
 protein coding gene Chr13:20748576-20796524 (+)
CAST/EiJ MGP_CASTEiJ_G0019653
 protein coding gene Chr13:22073942-22124948 (+)
CBA/J MGP_CBAJ_G0020090
 protein coding gene Chr13:24128037-24181713 (+)
DBA/2J MGP_DBA2J_G0020216
 protein coding gene Chr13:21523692-21571623 (+)
FVB/NJ MGP_FVBNJ_G0020200
 protein coding gene Chr13:21166240-21222505 (+)
LP/J MGP_LPJ_G0020289
 protein coding gene Chr13:22735922-22789032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020227
 protein coding gene Chr13:24381214-24435096 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020811
 protein coding gene Chr13:22121786-22184203 (+)
PWK/PhJ MGP_PWKPhJ_G0019407
 protein coding gene Chr13:21547658-21596643 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019223
 protein coding gene Chr13:20957788-21013621 (+)
WSB/EiJ MGP_WSBEiJ_G0019713
 protein coding gene Chr13:22292950-22341164 (+)



Homology
more
  • Human Ortholog
    GPLD1, glycosylphosphatidylinositol specific phospholipase D1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPLD1, glycosylphosphatidylinositol specific phospholipase D1
  • Synonyms
    GPIPLD, GPIPLDM, PIGPLD, PIGPLD1, PLD
  • Links
    NCBI Gene ID: 2822
    neXtProt AC: NX_P80108
    UniProt: P80108

  • Chr Location
    6p22.3; chr6:24423969-24495287 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    128
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14756 NCBI Gene Model | MGI Sequence Detail 48785 C57BL/6J ±  kb
    transcript NM_008156 RefSeq | MGI Sequence Detail 4659 ZRU/MplStud  
    polypeptide O70362 UniProt | EBI | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35061, MGI:1924474, MGI:2145449
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:346352 Li X, et al., Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice. Aging Cell. 2022 Sep;21(9):e13685
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory