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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gpld1
glycosylphosphatidylinositol specific phospholipase D1
MGI:106604
29 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gpld1em1Smoc/Gpld1em1Smoc
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6JSmoc * FVB/N 		abnormal myocardial fiber mitochondrial morphology J:379476
decreased cardiac muscle relaxation J:379476
decreased heart left ventricle muscle contractility J:379476
dilated heart left ventricle J:379476
increased cardiac muscle calcium level J:379476
increased protein level J:379476
increased response of heart to induced stress J:379476
Gpld1em2Smoc/Gpld1em2Smoc
C57BL/6JSmoc-Gpld1em2Smoc/Smoc 		cardiac fibrosis J:379476
cardiac hypertrophy J:379476
decreased cardiac muscle relaxation J:379476
decreased heart left ventricle muscle contractility J:379476
increased heart left ventricle size J:379476
increased heart left ventricle wall thickness J:379476
increased heart weight J:379476
increased myocardial fiber size J:379476
Gpld1tm1.1(KOMP)Vlcg/Gpld1tm1.1(KOMP)Vlcg
C57BL/6N-Gpld1tm1.1(KOMP)Vlcg/Ucd 		abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal testis morphology J:211773
decreased circulating cholesterol level J:211773
decreased total body fat amount J:211773
enlarged heart J:211773
enlarged kidney J:211773
increased brain weight J:211773
increased circulating alkaline phosphatase level J:211773
increased heart weight J:211773
increased kidney weight J:211773
increased lean body mass J:211773
increased spleen weight J:211773
preweaning lethality, incomplete penetrance J:211773
small testis J:211773
Gt(ROSA)26Sorem168(CAG-Gpld1,-tdTomato)Smoc/Gt(ROSA)26Sor+
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6JSmoc * FVB/N 		abnormal myocardial fiber mitochondrial morphology J:379476
decreased protein level J:379476
decreased response of heart to induced stress J:379476
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory