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Ap2a2 Gene Detail
Summary
  • Symbol
    Ap2a2
  • Name
    adaptor-related protein complex 2, alpha 2 subunit
  • Synonyms
    2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25
  • Feature Type
    protein coding gene
  • IDs
    MGI:101920
    NCBI Gene: 11772
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141142093-141212924 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.94 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101920
 protein coding gene Chr7:141142086-141212924 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033238
 protein coding gene Chr7:146757358-146837286 (+)
A/J MGP_AJ_G0033219
 protein coding gene Chr7:142564215-142636755 (+)
AKR/J MGP_AKRJ_G0033152
 protein coding gene Chr7:146519515-146596177 (+)
BALB/cJ MGP_BALBcJ_G0033220
 protein coding gene Chr7:142303193-142375560 (+)
C3H/HeJ MGP_C3HHeJ_G0032935
 protein coding gene Chr7:146255407-146329189 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033732
 protein coding gene Chr7:152109311-152185786 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030705
 protein coding gene Chr7:143766334-143838515 (+)
CAST/EiJ MGP_CASTEiJ_G0032265
 protein coding gene Chr7:138571138-138654044 (+)
CBA/J MGP_CBAJ_G0032907
 protein coding gene Chr7:157272798-157360144 (+)
DBA/2J MGP_DBA2J_G0033059
 protein coding gene Chr7:140507081-140578122 (+)
FVB/NJ MGP_FVBNJ_G0033012
 protein coding gene Chr7:140419279-140489863 (+)
LP/J MGP_LPJ_G0033154
 protein coding gene Chr7:148251312-148326662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033045
 protein coding gene Chr7:157910118-157990693 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033751
 protein coding gene Chr7:145471922-145546527 (+)
PWK/PhJ MGP_PWKPhJ_G0031969
 protein coding gene Chr7:133792182-133866131 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031815
 protein coding gene Chr7:132309916-132387440 (+)
WSB/EiJ MGP_WSBEiJ_G0032375
 protein coding gene Chr7:146426225-146503856 (+)



Homology
more
  • Human Ortholog
    AP2A2, adaptor related protein complex 2 subunit alpha 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP2A2, adaptor related protein complex 2 subunit alpha 2
  • Synonyms
    ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
  • Links
    NCBI Gene ID: 161
    neXtProt AC: NX_O94973
    UniProt: O94973

  • Chr Location
    11p15.5; chr11:924881-1012245 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    214
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11772 NCBI Gene Model | MGI Sequence Detail 70832 C57BL/6J ±  kb
    transcript NM_001357068 RefSeq | MGI Sequence Detail 4642 C57BL/6  
    polypeptide P17427 UniProt | EBI | MGI Sequence Detail 938 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 218
      Genomic 1
      cDNA 217

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 5
      Gene Ontology 18
      Phenotypes 19
    • Earliest
      J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
    • Latest
      J:327503 Xu Z, et al., Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage. Int Immunopharmacol. 2022 Jul 16;110:108941
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory