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Pecam1 Gene Detail
Summary
  • Symbol
    Pecam1
  • Name
    platelet/endothelial cell adhesion molecule 1
  • Synonyms
    Cd31, PECAM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97537
    NCBI Gene: 18613
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106545039-106606107 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 69.92 cM, cytoband F3-G1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1845 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97537
 protein coding gene Chr11:106545039-106641454 (-)
129S1/SvImJ ENSMUSG00200030171
 protein coding gene Chr11:103852360-103948290 (-)
A/J ENSMUSG00195018540
 protein coding gene Chr11:103551331-103647303 (-)
AKR/J ENSMUSG00220029837
 protein coding gene Chr11:103764419-103860338 (-)
BALB/cJ ENSMUSG00180016533
 protein coding gene Chr11:103873690-103969621 (-)
C3H/HeJ ENSMUSG00175011534
 protein coding gene Chr11:103822746-103918682 (-)
C57BL/6NJ ENSMUSG00215010120
 protein coding gene Chr11:103390727-103487169 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017326
 protein coding gene Chr11:102556261-102650772 (-)
CAST/EiJ ENSTCUG00005040213
 protein coding gene Chr11:103292865-103388412 (-)
CBA/J ENSMUSG00210013356
 protein coding gene Chr11:103531643-103628040 (-)
DBA/2J ENSMUSG00185019725
 protein coding gene Chr11:103872570-103968485 (-)
FVB/NJ ENSMUSG00205019111
 protein coding gene Chr11:103678043-103773979 (-)
JF1/MsJ ENSUMUG00000020151
 protein coding gene Chr11:104136087-104232459 (-)
LP/J ENSMUSG00230033387
 protein coding gene Chr11:104924738-105020553 (-)
NOD/ShiLtJ ENSMUSG00190021242
 protein coding gene Chr11:103871057-103966954 (-)
NZO/HlLtJ ENSMUSG00225051106
 protein coding gene Chr11:106960136-107055576 (-)
PWK/PhJ ENSLUMG00010016051
 protein coding gene Chr11:103665477-103761693 (-)
SPRET/EiJ ENSMSPG00010029671
 protein coding gene Chr11:104170566-104266336 (-)
WSB/EiJ ENSIUOG00005017103
 protein coding gene Chr11:103656038-103752368 (-)



Homology
more
  • Human Ortholog
    PECAM1, platelet and endothelial cell adhesion molecule 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PECAM1, platelet and endothelial cell adhesion molecule 1
  • Synonyms
    CD31, CD31/EndoCAM, endoCAM, GPIIA', PECA1, PECAM-1
  • Links
    NCBI Gene ID: 5175
    UniProt: P16284

  • Chr Location
    17q23.3; chr17:64319415-64413776 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human PECAM1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show increased susceptibility to collagen-induced arthritis, impaired lung alveolarization, and enhanced susceptibility to endotoxic shock. Mice homozygous for a gene-trapped allele show altered vasodilation and nitric oxide homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    104
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18613 NCBI Gene Model | MGI Sequence Detail 61069 C57BL/6J ±  kb
    transcript NM_001305157 RefSeq | MGI Sequence Detail 3327 C57BL/6  
    polypeptide Q08481 UniProt | EBI | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      Genomic 2
      cDNA 119
      Primer pair 30
      Other 4
      Antibodies 285

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13226, MGD-MRK-1848, MGI:2144682
    References
    more
    • Summaries
      All 2701
      Developmental Gene Expression 2478
      Gene Ontology 21
      Phenotypes 101
    • Earliest
      J:2787 Bogen SA, et al., Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation. Am J Pathol. 1992 Oct;141(4):843-54
    • Latest
      J:391428 Yang MJ, et al., Cooperative ETS transcription factors are required for lymphatic endothelial cell integrity and resilience. J Clin Invest. 2026 Mar 2;136(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory