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Itga6 Gene Detail
Summary
  • Symbol
    Itga6
  • Name
    integrin alpha 6
  • Synonyms
    5033401O05Rik, Cd49f
  • Feature Type
    protein coding gene
  • IDs
    MGI:96605
    NCBI Gene: 16403
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71617236-71688761 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1833 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96605
 protein coding gene Chr2:71575960-71688761 (+)
129S1/SvImJ ENSMUSG00200036754
 protein coding gene Chr2:68689753-68761295 (+)
A/J ENSMUSG00195020550
 protein coding gene Chr2:68836890-68908845 (+)
AKR/J ENSMUSG00220037954
 protein coding gene Chr2:68801589-68873537 (+)
BALB/cJ ENSMUSG00180036565
 protein coding gene Chr2:68790697-68862650 (+)
C3H/HeJ ENSMUSG00175031562
 protein coding gene Chr2:68905714-68977393 (+)
C57BL/6NJ ENSMUSG00215017464
 protein coding gene Chr2:68727628-68799308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023648
 protein coding gene Chr2:66299482-66414640 (+)
CAST/EiJ ENSTCUG00005008313
 protein coding gene Chr2:68213411-68285198 (+)
CBA/J ENSMUSG00210034255
 protein coding gene Chr2:68948495-69020172 (+)
DBA/2J ENSMUSG00185039732
 protein coding gene Chr2:68784227-68855905 (+)
FVB/NJ ENSMUSG00205024151
 protein coding gene Chr2:68246996-68318946 (+)
JF1/MsJ ENSUMUG00000004510
 protein coding gene Chr2:68446584-68518532 (+)
LP/J ENSMUSG00230020090
 protein coding gene Chr2:70590300-70662236 (+)
NOD/ShiLtJ ENSMUSG00190029432
 protein coding gene Chr2:68869854-68941801 (+)
NZO/HlLtJ ENSMUSG00225015130
 protein coding gene Chr2:78331802-78403476 (+)
PWK/PhJ ENSLUMG00010029139
 protein coding gene Chr2:68678750-68750707 (+)
SPRET/EiJ ENSMSPG00010033243
 protein coding gene Chr2:70078491-70148418 (+)
WSB/EiJ ENSIUOG00005017686
 protein coding gene Chr2:68912613-68984290 (+)



Homology
more
  • Human Ortholog
    ITGA6, integrin subunit alpha 6
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA6, integrin subunit alpha 6
  • Synonyms
    CD49f, ITGA6A, ITGA6B, JEB6, VLA-6
  • Links
    NCBI Gene ID: 3655
    UniProt: P23229

  • Chr Location
    2q31.1; chr2:172234216-172506459 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Itga6 mouse models; 2 with human ITGA6 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 5 alleles in 7 genetic backgrounds
    35 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit severe blistering of the skin and other epithelia, absence of hemidesmosomes, altered laminin deposition in brain, and ectopic neuroblastic outgrowths on the brain and in the eye. Mutants die at birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1529
  • Tissues
    475
  • cDNA Data
    255
  • Literature Summary
    156
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16403 NCBI Gene Model | MGI Sequence Detail 71526 C57BL/6J ±  kb
    transcript NM_008397 RefSeq | MGI Sequence Detail 6008 ZRU/MplStud  
    polypeptide Q61739 UniProt | EBI | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000009131 integrin alpha-6
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      Q61739 9 sites, 10 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 273
      Genomic 1
      cDNA 259
      Primer pair 9
      Other 4
      Antibodies 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11484, MGI:1923212, MGI:2138837
    References
    more
    • Summaries
      All 307
      Developmental Gene Expression 156
      Diseases 1
      Gene Ontology 36
      Phenotypes 55
    • Earliest
      J:35482 Sonnenberg A, et al., Laminin receptor on platelets is the integrin VLA-6. Nature. 1988 Dec 1;336(6198):487-9
    • Latest
      J:388914 Thompson SM, et al., Rete ridges form via evolutionarily distinct mechanisms in mammalian skin. Nature. 2026 Mar;651(8104):135-145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory