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Nrde2 Gene Detail
Summary
  • Symbol
    Nrde2
  • Name
    nrde-2 necessary for RNA interference, domain containing
  • Synonyms
    6720454P05Rik, BC002230
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670969
    NCBI Gene: 217827
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:100091711-100125912 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 50.43 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    971 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670969
protein coding gene Chr12:100091709-100126981 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020016
protein coding gene Chr12:101586281-101622162 (-)
A/J MGP_AJ_G0019971
protein coding gene Chr12:97770803-97804965 (-)
AKR/J MGP_AKRJ_G0019947
protein coding gene Chr12:100410349-100444528 (-)
BALB/cJ MGP_BALBcJ_G0019957
protein coding gene Chr12:98114167-98148342 (-)
C3H/HeJ MGP_C3HHeJ_G0019759
protein coding gene Chr12:100953170-100989314 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020406
protein coding gene Chr12:104723240-104760900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018020
protein coding gene Chr12:94742599-94777672 (-)
CAST/EiJ MGP_CASTEiJ_G0019305
protein coding gene Chr12:96064569-96101193 (-)
CBA/J MGP_CBAJ_G0019731
protein coding gene Chr12:108613278-108649077 (-)
DBA/2J MGP_DBA2J_G0019842
protein coding gene Chr12:97204907-97239277 (-)
FVB/NJ MGP_FVBNJ_G0019831
protein coding gene Chr12:95923799-95958415 (-)
LP/J MGP_LPJ_G0019918
protein coding gene Chr12:101428041-101463418 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019873
protein coding gene Chr12:112206735-112241312 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020435
protein coding gene Chr12:99984459-100019627 (-)
PWK/PhJ MGP_PWKPhJ_G0019069
protein coding gene Chr12:91837286-91872591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018865
protein coding gene Chr12:94161500-94196866 (-)
WSB/EiJ MGP_WSBEiJ_G0019359
protein coding gene Chr12:100835706-100871235 (-)



Homology
more
  • Human Ortholog
    NRDE2, NRDE-2, necessary for RNA interference, domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRDE2, NRDE-2, necessary for RNA interference, domain containing
  • Synonyms
    C14orf102
  • Links
    NCBI Gene ID: 55051
    neXtProt AC: NX_Q9H7Z3
    UniProt: Q9H7Z3

  • Chr Location
    14q32.11; chr14:90267860-90331969 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    10
  • Targeted
    4
  • Genomic Mutations
    1 involving Nrde2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021179 Ensembl Gene Model | MGI Sequence Detail 34202 C57BL/6J ±  kb
transcript ENSMUST00000021596 Ensembl | MGI Sequence Detail 3718 Not Applicable  
polypeptide ENSMUSP00000021596 Ensembl | MGI Sequence Detail 1172 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 2
Other
Accession IDs
less
MGI:2443747
References
more
  • Summaries
    All 39
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory